Gleevec (STI-571) inhibits lung cancer cell growth (A549) and potentiates the cisplatin effect in vitro

Molecular Cancer

Volumn 2, Issue , 2003, Pages

  Zhang, Peilin ^a   Gao, Wei Yi ^a   Turner, Steven ^b   Ducatman, Barbara S ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b Protea Biosciences   (United States)

Author keywords

Gleevec (STI571); Lung cancer A549 cell; PDGF receptor

Indexed keywords

ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; CISPLATIN; IMATINIB; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; STEM CELL FACTOR RECEPTOR; UNCLASSIFIED DRUG; GROWTH INHIBITOR; PIPERAZINE DERIVATIVE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PYRIMIDINE DERIVATIVE;

ARTICLE; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG APPROVAL; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG PROTEIN BINDING; ENZYME INHIBITION; FOOD AND DRUG ADMINISTRATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MITOSIS INHIBITION; PROTEIN MICROARRAY; PROTEIN PHOSPHORYLATION; SQUAMOUS CELL CARCINOMA; CELL LINE; CELL PROLIFERATION; DRUG EFFECT; LUNG TUMOR; METABOLISM; PATHOLOGY; TISSUE MICROARRAY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; DRUG SYNERGISM; GROWTH INHIBITORS; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; PIPERAZINES; PYRIMIDINES; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; TISSUE ARRAY ANALYSIS;

EID: 0141799739     PISSN: 14764598     EISSN: None     Source Type: Journal    
DOI: 10.1186/1476-4598-2-1     Document Type: Article

References (16)

1. Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, Zhu J and Johnson DH Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 2002, 346:92-98
2. Hoang T, Traynor AM and Schiller JH Novel therapies for lung cancer. Surg Oncol 2002, 11:229-241
3. Sartor CI Molecular targets as therapeutic strategies in the management of breast cancer. Semin Radiat Oncol 2002, 12:341-351
4. Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R and Ohno-Jones S Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001, 344:1031-1037
5. Buchdunger E, Cioffi CL, Law N, Stover D, Ohno-Jones S, Druker BJ and Lydon NB Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 2000, 295:139-145
6. Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D, Silberman S, Capdeville R, Dimitrijevic S and Druker B Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med 2001, 344:1052-1056
7. Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S and Janicek M Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002, 347:472-480
8. Maki RG, Awan RA, Dixon RH, Jhanwar S and Antonescu CR Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans. Int J Cancer 2002, 100:623-626
9. Rubin BP, Schuetze SM, Eary JF, Norwood TH, Mirza S, Conrad EU and Bruckner JD Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. J Clin Oncol 2002, 20:3586-3591
10. Okuda K, Weisberg E, Gilliland DG and Griffin JD ARG tyrosine kinase activity is inhibited by STI571. Blood 2001, 97:2440-2448
11. George D Platelet-derived growth factor receptors: a therapeutic target in solid tumors. Semin Oncol 2001, 28:27-33
12. Ross R, Bowen-Pope DF and Raines EW Platelet-derived growth factor: its potential roles in wound healing, atherosclerosis, neoplasia, and growth and development. Ciba Found Symp 1985, 116:98-112
13. Reed E Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy. Cancer Treat Rev 1998, 24:331-344
14. Wang JY Cellular responses to DNA damage. Curr Opin Cell Biol 1998, 10:240-247
15. Li Z, Lin H, Zhu Y, Wang M and Luo J Disruption of cell cycle kinetics and cyclin-dependent kinase system by ethanol in cultured cerebellar granule progenitors. Brain Res Dev Brain Res 2001, 132:47-58
16. Luo J and Miller MW Platelet-derived growth factor-mediated signal transduction underlying astrocyte proliferation: site of ethanol action. J Neurosci 1999, 19:10014-10025