The effects of lysosomal and proteasomal inhibitors on abnormal forms of prion protein degradation in murine macrophages

Microbiology and Immunology

Volumn 54, Issue 12, 2010, Pages 763-768

  Sassa, Yukiko ^a   Yamasaki, Takeshi ^b   Horiuchi, Motohiro ^b   Inoshima, Yasuo ^a   Ishiguro, Naotaka ^a  

^a GIFU UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Lysosome; Macrophage; Prion; Proteasome

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; ENZYME INHIBITOR; LEUPEPTIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME INHIBITOR; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PRION PROTEIN; PROTEASOME INHIBITOR; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG MECHANISM; FLUORESCENCE ANALYSIS; MACROPHAGE FUNCTION; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SCRAPIE; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; LYSOSOMES; MACROPHAGES; MICE; PROTEASOME ENDOPEPTIDASE COMPLEX; PRPSC PROTEINS; UBIQUITIN;

MURINAE;

EID: 78649526582     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2010.00272.x     Document Type: Article

References (18)

1. Collinge J., Sidle K.C., Meads J., Ironside J., Hill A.F. (1996) Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD. Nature 383: 685-90.
2. + dendritic cells and GT1-1 neuronal cells. J Virol 78: 4776-82.
3. Sc. Vet Immunol Immunopathol 133: 33-9.
4. + myeloid dendritic cells in vitro. J Virol 76: 12, 259-64.
5. Ma J.Y., Lindquist S. (2001) Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation. Proc Natl Acad Sci USA 98: 14, 955-60.
6. Shinagawa M., Munekata E., Doi S., Takahashi K., Goto H., Sato G. (1986) Immunoreactibity of a synthetic pentadecapeptide corresponding to the N-terminal region of the scrapie prion protein. J Gen Virol 67: 1745-50.
7. Clarke MC and Haig DA (1970). Evidence for the multiplication of scrapie agent in cell culture. Nature 225: 100-101.
8. Yedidia Y., Horonchik L., Tzaban S., Yanai A., Taraboulos A. (2001) Proteasomes and ubiquitin are involved in turnover of the wild-type prion protein. EMBO J 20: 5383-91.
9. Doh-ura K., Iwaki T., Caughey B. (2000) Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. J Virol 74: 4894-7.
10. C by anti-PrP antibody prevents protease-resistant PrP formation. J Gen Virol 85: 3473-82.
11. Wadsworth J.D., Joiner S., Hill A.F., Campbell T.A., Desbruslais M., Luthert P.J., Collinge J. (2001) Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay. Lancet 358: 171-80.
12. Kim C.L., Umetani A., Matsui T., Ishiguro N., Shinagawa M., Horiuchi M. (2004) Antigenic characterization of an abnormal isoform of prion protein using a new disease panel of monoclonal antibodies. Virology 320: 40-51.
13. Rybner-Barnier C., Jacquemot C., Cuche C., Dore G., Majlessi L., Gabellec M., Moris A., Schwarts O., Santo J., Cumano A., Leclerc C., Lazarini F. (2006) Processing of the bovine spongiform encephalopathy-specific prion protein by dendritic cells. J Virol 80: 4656-63.
14. Nakamitsu S., Kurokawa A., Yamasaki T., Uryu M., Hasebe R. Horiuchi M. (2009) Cell density-dependent increase in the level of protease-resistant PrP in prion-infected neuro2a mouse neuroblastoma cells. J Gen Virol 91: 153-9.
15. Rabinowitz S., Horstmann H., Gordon S., Griffiths G. (1992) Immunocytochemical characterization of the endocytic and phagolysosomal compartments in peritoneal macrophages. J Cell Biol 116: 95-112.
16. Verhoef L.G., Lindsten K., Masucci M.G., Dantuma N.P. (2002) Aggregate formation inhibits proteasomal degradation of polyglutamine proteins. Hum Mol Genet 11: 2689-700.
17. Beauvillain C., Delneste Y., Scotet M., Peres A., Gascan H., Guermonprez P., Barnaba V., Jeannin P. (2007) Neutrophils efficiently cross-prime naive T cells in vivo. Blood 110: 2965-73.
18. Heiseke A., Aguib Y., Schaetzl H.M. (2009) Autophagy, prion infection and their mutual interactions. Curr Issues Mol Biol 12: 87-98.