Effector T cells driving monophasic vs. relapsing/remitting experimental autoimmune uveitis show unique pathway signatures

Molecular Immunology

Volumn 48, Issue 1-3, 2010, Pages 272-280

  Von Toerne, Christine ^a   Sieg, Cornelia ^a   Kaufmann, Ulrike ^a   Diedrichs Möhring, Maria ^a   Nelson, Peter J ^a   Wildner, Gerhild ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Autoimmune disease; Gene expression; Relapsing remitting; Rodent; Signaling pathways; T cells

Indexed keywords

AUTOANTIGEN; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; RETINA S ANTIGEN; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CELL HETEROGENEITY; CELL LINE; CELL SURVIVAL; DISEASE COURSE; EFFECTOR CELL; FEMALE; GENE EXPRESSION; HEDGEHOG; HUMAN; IN VIVO CULTURE; LYMPHOCYTE ACTIVATION; MALE; MICROARRAY ANALYSIS; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RECURRENT DISEASE; RELAPSE; T LYMPHOCYTE; TH1 CELL; TH17 CELL; TRANSCRIPTOMICS; UPREGULATION; UVEITIS;

ANIMALS; ARRESTIN; AUTOANTIGENS; AUTOIMMUNE DISEASES; CELL SEPARATION; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, INBRED LEW; RETINOL-BINDING PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; UVEITIS;

RATTUS; RODENTIA;

EID: 78649518005     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2010.07.017     Document Type: Article

References (37)

1. Adams J., Kiss E., Arroyo A.B.V., Bonrouhi M., Sun Q., Li Z., Gretz N., Schnitger A., Zouboulis C.C., Wiesel M., Wagner J., Nelson P.J., Grone H.-J. 13-cis retinoic acid inhibits development and progression of chronic allograft nephropathy. American Journal of Pathology 2005, 167:285-298.
2. Alam A., Cohen L.Y., Aouad S., Sekaly R.P. Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells. Journal of Experimental Medicine 1999, 190:1879-1890.
3. Allan S.E., Crome S.Q., Crellin N.K., Passerini L., Steiner T.S., Bacchetta R., Roncarolo M.G., Levings M.K. Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. International Immunology 2007, 19:345-354.
4. Casey T.M., Meade J.L., Hewitt E.W. Organelle proteomics: identification of the exocytic machinery associated with the natural killer cell secretory lysosome. Molecular & Cellular Proteomics 2007, 6:767-780.
5. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry 1987, 162:156-159.
6. Cohen C.D., Lindenmeyer M.T., Eichinger F., Hahn A., Seifert M., Moll A.G., Schmid H., Kiss E., Grone E., Grone H.-J., Kretzler M., Werner T., Nelson P.J. Improved elucidation of biological processes linked to diabetic nephropathy by single probe-based microarray data analysis. PLoS ONE [Electronic Resource] 2008, 3:e2937.
7. Crompton T., Outram S.V., Hager-Theodorides A.L. Sonic hedgehog signalling in T-cell development and activation. Nature Reviews Immunology 2007, 7:726-735.
8. de Smet M.D., Bitar G., Mainigi S., Nussenblatt R.B. Human S-antigen determinant recognition in uveitis. Investigative Ophthalmology & Visual Science 2001, 42:3233-3238.
9. de Smet M.D., Bitar G., Roberge F.G., Gery I., Nussenblatt R.B. Human S-antigen: presence of multiple immunogenic and immunopathogenic sites in the Lewis rat. Journal of Autoimmunity 1993, 6:587-599.
10. Dennis G., Sherman B.T., Hosack D.A., Yang J., Gao W., Lane H.C., Lempicki R.A. DAVID: database for annotation, visualization, and integrated discovery. Genome Biology 2003, 4:P3.
11. Diedrichs Mohring M., Nelson P.J., Proudfoot A.E., Thurau S.R., Wildner G. The effect of the CC chemokine receptor antagonist Met-RANTES on experimental autoimmune uveitis and oral tolerance. Journal of Neuroimmunology 2005, 164:22-30.
12. Diedrichs-Mohring M., Hoffmann C., Wildner G. Antigen-dependent monophasic or recurrent autoimmune uveitis in rats. International Immunology 2008, 20:365-374.
13. Dobrosotskaya I., Guy R.K., James G.L. MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains. Journal of Biological Chemistry 1997, 272:31589-31597.
14. Dobrosotskaya I.Y, James G.L. MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures. Biochemical & Biophysical Research Communications 2000, 270:903-909.
15. Flugel A., Willem M., Berkowicz T., Wekerle H. Gene transfer into CD4+ T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses. Nature Medicine 1999, 5:843-847.
16. Gansbacher B., Zier K.S. HLA class II mRNA accumulation by activated human T cells following growth in conditioned medium. Clinical & Experimental Immunology 1989, 76:440-445.
17. Gattinoni L., Zhong X.-S., Palmer D.C., Ji Y., Hinrichs C.S., Yu Z., Wrzesinski C., Boni A., Cassard L., Garvin L.M., Paulos C.M., Muranski P., Restifo N.P. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nature Medicine 2009, 15:808-813.
18. Holt O.J., Gallo F., Griffiths G.M. Regulating secretory lysosomes. Journal of Biochemistry 2006, 140:7-12.
19. Kim S.-Y. Transglutaminase 2 in inflammation. Frontiers in Bioscience 2006, 11:3026-3035.
20. Kim S.-Y., Jeong E.-J., Steinert P.M. IFN-gamma induces transglutaminase 2 expression in rat small intestinal cells. Journal of Interferon & Cytokine Research 2002, 22:677-682.
21. Leng L., Metz C.N., Fang Y., Xu J., Donnelly S., Baugh J., Delohery T., Chen Y., Mitchell R.A., Bucala R. MIF signal transduction initiated by binding to CD74. Journal of Experimental Medicine 2003, 197:1467-1476.
22. Lowrey J.A., Stewart G.A., Lindey S., Hoyne G.F., Dallman M.J., Howie S.E.M., Lamb J.R. Sonic hedgehog promotes cell cycle progression in activated peripheral CD4(+) T lymphocytes. Journal of Immunology 2002, 169:1869-1875.
23. Orsulic S., Huber O., Aberle H., Arnold S., Kemler R. E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation. Journal of Cell Science 1999, 112:1237-1245.
24. Patrie K.M., Drescher A.J., Welihinda A., Mundel P., Margolis B. Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1. Journal of Biological Chemistry 2002, 277:30183-30190.
25. Pfaffl M.W A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Research 2001, 29:e45.
26. Puga I., Rao A., Macian F. Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells. Immunity 2008, 29:193-204.
27. Rowbotham N.J., Hager-Theodorides A.L., Cebecauer M., Shah D.K., Drakopoulou E., Dyson J., Outram S.V., Crompton T. Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation. Blood 2007, 109:3757-3766.
28. Sarris A.H., Esgleyes-Ribot T., Crow M., Broxmeyer H.E., Karasavvas N., Pugh W., Grossman D., Deisseroth A., Duvic M. Cytokine loops involving interferon-gamma and IP-10, a cytokine chemotactic for CD4+ lymphocytes: an explanation for the epidermotropism of cutaneous T-cell lymphoma?. Blood 1995, 86:651-658.
29. Schmid H., Cohen C.D., Henger A., Irrgang S., Schlondorff D., Kretzler M. Validation of endogenous controls for gene expression analysis in microdissected human renal biopsies. Kidney International 2003, 64:356-360.
30. Staal F.J.T., Luis T.C., Tiemessen M.M. WNT signalling in the immune system: WNT is spreading its wings. Nature Reviews Immunology 2008, 8:581-593.
31. Stewart G.A., Lowrey J.A., Wakelin S.J., Fitch P.M., Lindey S., Dallman M.J., Lamb J.R., Howie S.E.M. Sonic hedgehog signaling modulates activation of and cytokine production by human peripheral CD4+ T cells. Journal of Immunology 2002, 169:5451-5457.
32. Taams L.S., van Eden W., Wauben M.H. Antigen presentation by T cells versus professional antigen-presenting cells (APC): differential consequences for T cell activation and subsequent T cell-APC interactions. European Journal of Immunology 1999, 29:1543-1550.
33. Wildner G., Thurau S.R. Crossreactivity between an HLA-B27 derived peptide and a retinal autoantigen peptide: A clue to MHC-association with autoimmune disease. European Journal of Immunology 1994, 24:2579-2585.
34. Wildner G., Diedrichs Mohring M. Differential recognition of a retinal autoantigen peptide and its variants by rat T cells in vitro and in vivo. International Immunology 2003, 15:927-935.
35. Wildner G., Hunig T., Thurau S.R. Orally induced, peptide-specific gamma/delta TCR+ cells suppress experimental autoimmune uveitis. European Journal of Immunology 1996, 26:2140-2148.
36. Wong A.W., Ghosh N., McKinnon K.P., Reed W., Piskurich J.F., Wright K.L., Ting J.P.Y. Regulation and specificity of MHC2TA promoter usage in human primary T lymphocytes and cell line. Journal of Immunology 2002, 169:3112-3119.
37. Yang D.D., Conze D., Whitmarsh A.J., Barrett T., Davis R.J., Rincon M., Flavell R.A. Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity 1998, 9:575-585.