Targeted disruption of ing2 results in defective spermatogenesis and development of soft-tissue sarcomas

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Saito, Motonobu ^a,b   Kumamoto, Kensuke ^a,b   Robles, Ana I ^a   Horikawa, Izumi ^a   Furusato, Bungo ^c   Okamura, Shu ^a   Goto, Akiteru ^a   Yamashita, Taro ^a   Nagashima, Makoto ^a   Lee, Tin Lap ^d   Baxendale, Vanessa J ^d   Rennert, Owen M ^d   Takenoshita, Seiichi ^b   Yokota, Jun ^e   Sesterhenn, Isabell A ^c   Trivers, Glenwood E ^a   Hussain, S Perwez ^a   Harris, Curtis C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^c ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^d EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^e NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE 1; INHIBITOR OF GROWTH FAMILY MEMBER 2; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; ING2 PROTEIN, MOUSE;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL DISRUPTION; CELL MATURATION; CHROMATIN; CONTROLLED STUDY; GENE EXPRESSION; GERM CELL; GERM LINE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MALE INFERTILITY; MEIOSIS; MOUSE; NONHUMAN; PACHYTENE; PHENOTYPE; PROTEIN DEFICIENCY; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INDUCTION; SEMINIFEROUS TUBULE; SERTOLI CELL; SOFT TISSUE SARCOMA; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS; 129 MOUSE; ANIMAL; ATROPHY; C57BL MOUSE; FEMALE; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE MUTANT; NICK END LABELING; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARCOMA; SPERM; WESTERN BLOTTING;

ANIMALIA; MUS;

ANIMALS; APOPTOSIS; ATROPHY; BLOTTING, WESTERN; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFERTILITY, MALE; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SARCOMA; SEMEN; SEMINIFEROUS TUBULES; SPERMATOGENESIS; TESTIS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 78649510867     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015541     Document Type: Article

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