Gonadal dysfunction and fertility problems in cancer survivors

Acta Oncologica

Volumn 46, Issue 4, 2007, Pages 480-489

  Brydøy, Marianne ^a,b   Fosså, Sophie D ^c   Dahl, Olav ^a,b   Bjøro, Trine ^d  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BLEOMYCIN; BUSULFAN; CARBOPLATIN; CHLORAMBUCIL; CHLORMETHINE; CISPLATIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DACTINOMYCIN; DOXORUBICIN; EPIRUBICIN; FLUOROURACIL; FOLLITROPIN; IFOSFAMIDE; IRINOTECAN; LUTEINIZING HORMONE; MELPHALAN; MERCAPTOPURINE; METHOTREXATE; OXALIPLATIN; PREDNISOLONE; PREDNISONE; PROCARBAZINE; PROTEIN TYROSINE KINASE INHIBITOR; TAXANE DERIVATIVE; TESTOSTERONE; UNINDEXED DRUG; VINBLASTINE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; AZOOSPERMIA; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CANCER SURVIVOR; CRYOPRESERVATION; ENDOCRINE FUNCTION; ESTROGEN DEFICIENCY; FEMALE INFERTILITY; FOLLOW UP; GONAD DYSFUNCTION; GONAD FUNCTION; HODGKIN DISEASE; HUMAN; HYPOGONADISM; MALE INFERTILITY; NONHODGKIN LYMPHOMA; OLIGOSPERMIA; OOCYTE; OSTEOPOROSIS; PREMATURE OVARIAN FAILURE; PRIORITY JOURNAL; REVIEW; SPERM; SPERMATOGENESIS; STATISTICAL SIGNIFICANCE; TESTIS CANCER;

DRUG THERAPY; FEMALE; GONADAL DISORDERS; HUMANS; INFERTILITY; MALE; NEOPLASMS; RADIOTHERAPY; SURVIVORS;

EID: 34248545711     PISSN: 0284186X     EISSN: 1651226X     Source Type: Journal    
DOI: 10.1080/02841860601166958     Document Type: Review

References (74)

1. Cancer registry of Norway. Cancer in Norway 2004. 2006;1-111 also available at http:/www.kreftregisteret.no.
2. Janowsky JS. The role of androgens in cognition and brain aging in men. Neuroscience 2006;138:1015-20.
3. Beck-Peccoz P, Persani L. Premature ovarian failure. Orphanet J Rare Dis 2006;1:9.
4. Matsumoto AM. Andropause: Clinical implications of the decline in serum testosterone levels with aging in men. J Gerontol A Biol Sci Med Sci 2002;57:M76-99.
5. Ohta H, Sugimoto I, Masuda A, Komukai S, Suda Y, Makita K, et al. Decreased bone mineral density associated with early menopause progresses for at least ten years: Cross-sectional comparisons between early and normal menopausal women. Bone 1996;18:227-31.
6. Anasti JN, Kalantaridou SN, Kimzey LM, Defensor RA, Nelson LM. Bone loss in young women with karyotypically normal spontaneous premature ovarian failure. Obstet Gynecol 1998;91:12-5.
7. Adler RA. Epidemiology and pathophysiology of osteoporosis in men. Curr Osteoporos Rep 2006;4:110-5.
8. Colditz GA, Willett WC, Stampfer MJ, Rosner B, Speizer FE, Hennekens CH. Menopause and the risk of coronary heart disease in women. N Engl J Med 1987;316:1105-10.
9. van der Schouw YT, van der Graaf Y, Steyerberg EW, Eijkemans JC, Banga JD. Age at menopause as a risk factor for cardiovascular mortality. Lancet 1996;347:714-8.
10. Shabsigh R, Katz M, Yan G, Makhsida N. Cardiovascular issues in hypogonadism and testosterone therapy. Am J Cardiol 2005;96(Suppl):67M-72M.
11. Lee SJ, Schover LR, Partridge AH, Patrizio P, Wallace WH, Hagerty K, et al. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol 2006;24:2917-31.
12. Wallace WH, Anderson RA, Irvine DS. Fertility preservation for young patients with cancer: Who is at risk and what can be offered? Lancet Oncol 2005;6:209-18.
13. Islam N, Trainer PJ. The hormonal assessment of the infertile male. Br J Urol 1998;82:69-75.
14. Rowley MJ, Leach DR, Warner GA, Heller CG. Effect of graded doses of ionizing radiation on the human testis. Radiat Res 1974;59:665-78.
15. Waring AB,Wallace WH. Subfertility following treatment for childhood cancer. Hosp Med 2000;61:550-7.
16. Skakkebæk NE, Rajpert-De Meyts E, Main KM. Testicular dysgenesis syndrome: An increasingly common developmental disorder with environmental aspects. Hum Reprod 2001;16:972-8.
17. Petersen PM, Skakkebæk NE, Vistisen K, Rørth M, Giwercman A. Semen quality and reproductive hormones before orchiectomy in men with testicular cancer. J Clin Oncol 1999;17:941-7.
18. Berthelsen JG, Skakkebæk NE. Gonadal function in men with testis cancer. Fertil Steril 1983;39:68-75.
19. Rueffer U, Breuer K, Josting A, Lathan B, Sieber M, Manzke O, et al. Male gonadal dysfunction in patients with Hodgkin's disease prior to treatment. Ann Oncol 2001;12:1307-11.
20. Viviani S, Ragni G, Santoro A, Perotti L, Caccamo E, Negretti E, et al. Testicular dysfunction in Hodgkin's disease before and after treatment. Eur J Cancer 1991;27:1389-92.
21. Fitoussi, Eghbali H, Tchen N, Berjon JP, Soubeyran P, Hoerni B. Semen analysis and cryoconservation before treatment in Hodgkin's disease. Ann Oncol 2000;11:679-84.
22. Barr RD, Clark DA, Booth JD. Dyspermia in men with localized Hodgkin's disease. A potentially reversible, immune-mediated disorder. Med Hypotheses 1993;40:165-8.
23. Fosså SD, Magelssen H, Melve K, Jacobsen AB, Langmark F, Skjærven R. Parenthood in survivors after adulthood cancer and perinatal health in their offspring: A preliminary report. J Natl Cancer Inst Monogr 2005;34:77-82.
24. Shepherd JH, Spencer C, Herod J, Ind TE. Radical vaginal trachelectomy as a fertility-sparing procedure in women with early-stage cervical cancer - cumulative pregnancy rate in a series of 123 women. BJOG 2006;113:719-24.
25. Trope CG, Kristensen G, Makar A. Surgery for borderline tumor of the ovary. Semin Surg Oncol 2000;19:69-75.
26. Petersen PM, Skakkebæk NE, Rørth M, Giwercman A. Semen quality and reproductive hormones before and after orchiectomy in men with testicular cancer. J Urol 1999;161:822-6.
27. Jacobsen KD, Theodorsen L, Fossa° SD. Spermatogenesis after unilateral orchiectomy for testicular cancer in patients following surveillance policy. J Urol 2001;165:93-6.
28. Donohue JP, Thornhill JA, Foster RS, Rowland RG, Bihrle R. Retroperitoneal lymphadenectomy for clinical stage A testis cancer (1965 to 1989): Modifications of technique and impact on ejaculation. J Urol 1993;149:237-43.
29. Jacobsen KD, Ous S, Wæhre H, Trasti H, Stenwig AE, Lien HH, et al. Ejaculation in testicular cancer patients after postchemotherapy retroperitoneal lymph node dissection. Br J Cancer 1999;80:249-55.
30. Hansen PV, Trykker H, Svennekjær IL, Hvolby J. Long-term recovery of spermatogenesis after radiotherapy in patients with testicular cancer. Radiother Oncol 1990;18:117-25.
31. Kinsella TJ, Trivette G, Rowland J, Sorace R, Miller R, Fraass B, et al. Long-term follow-up of testicular function following radiation therapy for early-stage Hodgkin's disease. J Clin Oncol 1989;7:718-24.
32. Centola GM, Keller JW, Henzler M, Rubin P. Effect of low-dose testicular irradiation on sperm count and fertility in patients with testicular seminoma. J Androl 1994;15:608-13.
33. Jacobsen KD, Olsen DR, Fosså K, Fosså SD. External beam abdominal radiotherapy in patients with seminoma stage I: Field type, testicular dose, and spermatogenesis. Int J Radiat Oncol Biol Phys 1997;38:95-102.
34. Joos H, Sedlmayer F, Gomahr A, Rahim HB, Frick J, Kogelnik HD, et al. Endocrine profiles after radiotherapy in stage I seminoma: Impact of two different radiation treatment modalities. Radiother Oncol 1997;43:159-62.
35. Shapiro E, Kinsella TJ, Makuch RW, Fraass BA, Glatstein E, Rosenberg SA, et al. Effects of fractionated irradiation of endocrine aspects of testicular function. J Clin Oncol 1985;3:1232-9.
36. Petersen PM, Giwercman A, Daugaard G, Rørth M, Petersen JH, Skakkebæk NE, et al. Effect of graded testicular doses of radiotherapy in patients treated for carcinoma-insitu in the testis. J Clin Oncol 2002;20:1537-43.
37. Dueland S, Guren MG, Olsen DR, Poulsen JP, Tveit KM. Radiation therapy induced changes in male sex hormone levels in rectal cancer patients. Radiother Oncol 2003;68:249-53.
38. Hermann RM, Henkel K, Christiansen H, Vorwerk H, Hille A, Hess CF, et al. Testicular dose and hormonal changes after radiotherapy of rectal cancer. Radiother Oncol 2005;75:83-8.
39. Wallace WH, Thomson AB, Saran F, Kelsey TW. Predicting age of ovarian failure after radiation to a field that includes the ovaries. Int J Radiat Oncol Biol Phys 2005;62:738-44.
40. Budgell GJ, Cowan RA, Hounsell AR. Prediction of scattered dose to the testes in abdominopelvic radiotherapy. Clin Oncol (R Coll Radiol) 2001;13:120-5.
41. Critchley HO, Bath LE, Wallace WH. Radiation damage to the uterus - review of the effects of treatment of childhood cancer. Hum Fertil 2002;5:61-6.
42. Socie G, Salooja N, Cohen A, Rovelli A, Carreras E, Locasciulli A, et al. Nonmalignant late effects after allogeneic stem cell transplantation. Blood 2003;101:3373-85.
43. Gleeson HK, Shalet SM. The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours. Endocr Relat Cancer 2004;11:589-602.
44. Hyer S, Vini L, O'Connell M, Pratt B, Harmer C. Testicular dose and fertility in men following I(131) therapy for thyroid cancer. Clin Endocrinol (Oxf) 2002;56:755-8.
45. Bal C, Kumar A, Tripathi M, Chandrashekar N, Phom H, Murali NR, et al. High-dose radioiodine treatment for differentiated thyroid carcinoma is not associated with change in female fertility or any genetic risk to the offspring. Int J Radiat Oncol Biol Phys 2005;63:449-55.
46. Magelssen H, Brydøy M, Fosså SD. The effects of cancer and cancer treatments on male reproductive function. Nat Clin Pract Urol 2006;3:312-22.
47. Viviani S, Santoro A, Ragni G, Bonfante V, Bestetti O, Bonadonna G. Gonadal toxicity after combination chemotherapy for Hodgkin's disease. Comparative results of MOPP vs ABVD. Eur J Cancer Clin Oncol 1985;21:601-5.
48. Pryzant RM, Meistrich ML, Wilson G, Brown B, McLaughlin P. Long-term reduction in sperm count after chemotherapy with and without radiation therapy for non-Hodgkin's lymphomas. J Clin Oncol 1993;11:239-47.
49. Byrne J, Fears TR, Mills JL, Zeltzer LK, Sklar C, Meadows AT, et al. Fertility of long-term male survivors of acute lymphoblastic leukemia diagnosed during childhood. Pediatr Blood Cancer 2004;42:364-72.
50. Byrne J, Fears TR, Mills JL, Zeltzer LK, Sklar C, Nicholson HS, et al. Fertility in women treated with cranial radiotherapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2004;42:589-97.
51. Lampe H, Horwich A, Norman A, Nicholls J, Dearnaley DP. Fertility after chemotherapy for testicular germ cell cancers. J Clin Oncol 1997;15:239-45.
52. Brydøy M, Fosså SD, Klepp O, Bremnes RM, Wist EA, Wentzel-Larsen T, et al. Paternity following treatment for testicular cancer. J Natl Cancer Inst 2005;97:1580-8.
53. Huddart RA, Norman A, Moynihan C, Horwich A, Parker C, Nicholls E, et al. Fertility, gonadal and sexual function in survivors of testicular cancer. Br J Cancer 2005;93:200-7.
54. Huyghe E, Matsuda T, Daudin M, Chevreau C, Bachaud JM, Plante P, et al. Fertility after testicular cancer treatments: Results of a large multicenter study. Cancer 2004;100:732-7.
55. Nord C, Bjøro T, Ellingsen D, Mykletun A, Dahl O, Klepp O, et al. Gonadal hormones in long-term survivors 10 years after treatment for unilateral testicular cancer. Eur Urol 2003;44:322-8.
56. Hodgson DC, Pintilie M, Gitterman L, Dewitt B, Buckley CA, Ahmed S, et al. Fertility among female hodgkin lymphoma survivors attempting pregnancy following ABVD chemotherapy. Hematol Oncol 2006 [Epub ahead of print].
57. Haukvik U, Dieset I, Bjøro T, Holte H, Fosså S. Treatment-related premature ovarian failure as a long-term complication after Hodgkin's lymphoma. Ann Oncol 2006;17:1428-33.
58. Albers P, Albrecht W, Algaba F, Bokemeyer C, Cohn-Cedermark G, Horwich A, et al. Guidelines on testicular cancer. Eur Urol 2005;48:885-94.
59. Rosenlund B, Sjoblom P, Tornblom M, Hultling C, Hillensjo T. In-vitro fertilization and intracytoplasmic sperm injection in the treatment of infertility after testicular cancer. Hum Reprod 1998;13:414-8.
60. Schwarzer JU, Fiedler K, Hertwig I, Krusmann G, Wurfel W, Schleyer M, et al. Sperm retrieval procedures and intracytoplasmatic spermatozoa injection with epididymal and testicular sperms. Urol Int 2003;70:119-23.
61. Oktay K, Buyuk E, Libertella N, Akar M, Rosenwaks Z. Fertility preservation in breast cancer patients: A prospective controlled comparison of ovarian stimulation with tamoxifen and letrozole for embryo cryopreservation. J Clin Oncol 2005;23:4347-53.
62. Sonmezer M, Oktay K. Fertility preservation in young women undergoing breast cancer therapy. Oncologist 2006;11:422-34.
63. Brougham MF, Kelnar CJ, Sharpe RM, Wallace WH. Male fertility following childhood cancer: Current concepts and future therapies. Asian J Androl 2003;5:325-37.
64. Blumenfeld Z, Avivi I, Linn S, Epelbaum R, Ben-Shahar M, Haim N. Prevention of irreversible chemotherapy-induced ovarian damage in young women with lymphoma by a gonadotrophin-releasing hormone agonist in parallel to chemotherapy. Hum Reprod 1996;11:1620-6.
65. Behringer K, Breuer K, Reineke T, May M, Nogova L, Klimm B, et al. Secondary amenorrhea after Hodgkin's lymphoma is influenced by age at treatment, stage of disease, chemotherapy regimen, and the use of oral contraceptives during therapy: A report from the German Hodgkin's Lymphoma Study Group. J Clin Oncol 2005;23:7555-64.
66. Meistrich ML, Shetty G. Suppression of testosterone stimulates recovery of spermatogenesis after cancer treatment. Int J Androl 2003;26:141-6.
67. Kalantaridou SN, Naka KK, Bechlioulis A, Makrigiannakis A, Michalis L, Chrousos GP. Premature ovarian failure, endothelial dysfunction and estrogen-progestogen replacement. Trends Endocrinol Metab 2006;17:101-9.
68. Kamischke A, Nieschlag E. Update on medical treatment of ejaculatory disorders. Int J Androl 2002;25:333-44.
69. Damani MN, Master V, Meng MV, Burgess C, Turek P, Oates RD, et al. Postchemotherapy ejaculatory azoospermia: Fatherhood with sperm from testis tissue with intracytoplasmic sperm injection. J Clin Oncol 2002;20:930-6.
70. Byrne J, Rasmussen SA, Steinhorn SC, Connelly RR, Myers MH, Lynch CF, et al. Genetic disease in offspring of long-term survivors of childhood and adolescent cancer. Am J Hum Genet 1998;62:45-52.
71. Shin D, Lo KC, Lipshultz LI. Treatment options for the infertile male with cancer. J Natl Cancer Inst Monogr 2005;34:48-50.
72. Bydder SA, Clarke J, Semmens J, Joseph DJ. Genetic counselling following paternal therapeutic irradiation. Australas Radiol 2005;49:119-21.
73. Gwyn K. Children exposed to chemotherapy in utero. J Natl Cancer Inst Monogr 2005;34:69-71.
74. De Mas P, Daudin M, Vincent MC, Bourrouillou G, Calvas P, Mieusset R, et al. Increased aneuploidy in spermatozoa from testicular tumour patients after chemotherapy with cisplatin, etoposide and bleomycin. Hum Reprod 2001;16:1204-8.