Cystogenesis in ARPKD results from increased apoptosis in collecting duct epithelial cells of Pkhd1 mutant kidneys

Experimental Cell Research

Volumn 317, Issue 2, 2011, Pages 173-187

  Hu, Bo ^a,b   He, Xiusheng ^a   Li, Ao ^d   Qiu, Qingchao ^a,b   Li, Cunxi ^b   Liang, Dan ^b   Zhao, Ping ^d   Ma, Jie ^d   Coffey, Robert J ^b,c   Zhan, Qimin ^d   Wu, Guanqing ^b,c,d  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CANCER HOSPITAL   (China)

Author keywords

Apoptosis; ARPKD; Fibrocystin; Pkhd1; Proliferation

Indexed keywords

BIOLOGICAL MARKER; CASPASE 3; CASPASE 9; FIBROCYSTIN; FOCAL ADHESION KINASE; HISTONE H3; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN BAX; PROTEIN KINASE B; RAF PROTEIN; RAS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOSOMAL RECESSIVE POLYCYSTIC KIDNEY DISEASE; CELL IMMORTALIZATION; CELL INTERACTION; CELL JUNCTION; CELL PROLIFERATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYSTOGENESIS; ENZYME ACTIVITY; EPITHELIUM CELL; GENE LOSS; GENE MUTATION; HISTOPATHOLOGY; HOMOZYGOTE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VIVO STUDY; KIDNEY CELL; KIDNEY COLLECTING TUBULE; KIDNEY EPITHELIUM; KIDNEY PARENCHYMA; KIDNEY POLYCYSTIC DISEASE; MOLECULAR DYNAMICS; MORPHOGENESIS; MOUSE; MUTANT; NICK END LABELING; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UPREGULATION; WILD TYPE;

MUS;

EID: 78649475651     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2010.09.012     Document Type: Article

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