메뉴 건너뛰기




Volumn 27, Issue 3, 2010, Pages 352-360

Oral toxicity at 60-days of sacha inchi oil (Plukenetia volubilis l.) and linseed (Linum usitatissimum l.), and determination of lethal dose 50 in rodents;Toxicidad oral a 60 días del aceite de sacha inchi (Plukenetia volubilis l.) y linaza (Linum usitatissimum l.) y determinación de la dosis letal 50 en roedores

Author keywords

Lethal dose 50; Medicinal; Pharmacology; Plants; Toxicity tests

Indexed keywords


EID: 78649431815     PISSN: 17264634     EISSN: 17264634     Source Type: Journal    
DOI: 10.1590/S1726-46342010000300007     Document Type: Article
Times cited : (39)

References (29)
  • 2
    • 78649405002 scopus 로고    scopus 로고
    • Colección, caracterización y mantenimiento de germoplasma de oleaginosas nativas. Estación Experimental Agraria El Porvenir - Instituto Nacional de Innovación Agraria (INIA)
    • Tarapoto: INIA
    • Arévalo G. Colección, caracterización y mantenimiento de germoplasma de oleaginosas nativas. Estación Experimental Agraria El Porvenir - Instituto Nacional de Innovación Agraria (INIA). Informes Anuales 1990-1995. Tarapoto: INIA; 1996.
    • (1996) Informes Anuales 1990-1995
    • Arévalo, G.1
  • 3
    • 0042929419 scopus 로고    scopus 로고
    • Characterization of sacha inchi (Plukenetia volubilis L.) oil by FTIR spectroscopy and 1H NMR. Comparison with linseed oil. Comparison with linseed oil
    • Guillén M, Ruiz A, Cabo N, Chirinos R, Pascual G. Characterization of sacha inchi (Plukenetia volubilis L.) oil by FTIR spectroscopy and 1H NMR. Comparison with linseed oil. Comparison with linseed oil. JAOCS. 2003;80(8):755-762.
    • (2003) JAOCS , vol.80 , Issue.8 , pp. 755-762
    • Guillén, M.1    Ruiz, A.2    Cabo, N.3    Chirinos, R.4    Pascual, G.5
  • 4
    • 78649438230 scopus 로고    scopus 로고
    • Oil quality indices
    • In: Wrolstad RE, Acree TE, An H, Decker EA, Penner MH, Reid DS, et al. (eds), New York: John Wiley & Sons, Inc
    • Cuppett S. Oil quality indices. In: Wrolstad RE, Acree TE, An H, Decker EA, Penner MH, Reid DS, et al. (eds). Current protocols in food analytical chemistry. New York: John Wiley & Sons, Inc.; 2001. p. D1.4.1-D1.4.3.
    • (2001) Current Protocols in Food Analytical Chemistry
    • Cuppett, S.1
  • 5
    • 78649421055 scopus 로고    scopus 로고
    • Investigation on the protective effect of Grape seed and Linseed oils against ciclophosphamide induced genotoxicity in mice
    • El-Rahim AH, Hafiz NA. Investigation on the protective effect of Grape seed and Linseed oils against ciclophosphamide induced genotoxicity in mice. Global Veterinaria. 2009;3(5):377-82.
    • (2009) Global Veterinaria , vol.3 , Issue.5 , pp. 377-382
    • El-Rahim, A.H.1    Hafiz, N.A.2
  • 6
    • 70350059182 scopus 로고    scopus 로고
    • Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: Benefits for human health and a role in maintaining tissue n-3 fatty acid levels
    • Barceló-Coblijn G, Murphy EJ. Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. Prog Lipid Res. 2009;48(6):355-74.
    • (2009) Prog Lipid Res , vol.48 , Issue.6 , pp. 355-374
    • Barceló-Coblijn, G.1    Murphy, E.J.2
  • 7
    • 0032938934 scopus 로고    scopus 로고
    • Effects of dietary alpha- or gamma-linolenic acid on levels and fatty acid compositions of serum and hepatic lipids, and activity and mRNA abundance of 3-hydroxy-3-methylglutaryl CoA reductase in rats
    • Ihara-Watanabe M, Umekawa H, Takahashi T, Furuichi Y. Effects of dietary alpha- or gamma-linolenic acid on levels and fatty acid compositions of serum and hepatic lipids, and activity and mRNA abundance of 3-hydroxy-3-methylglutaryl CoA reductase in rats. Comp Biochem Physiol A Mol Integr Physiol. 1999;122(2):213-20.
    • (1999) Comp Biochem Physiol a Mol Integr Physiol , vol.122 , Issue.2 , pp. 213-220
    • Ihara-Watanabe, M.1    Umekawa, H.2    Takahashi, T.3    Furuichi, Y.4
  • 8
    • 70849133154 scopus 로고    scopus 로고
    • Association of Official Analytical Chemists (AOAC), Arlington, VA: AOAC
    • Association of Official Analytical Chemists (AOAC). AOAC official methods of analysis. Arlington, VA: AOAC; 2005.
    • (2005) AOAC Official Methods of Analysis
  • 9
    • 85020847335 scopus 로고    scopus 로고
    • Laboratorio de Análisis Fisicoquímico
    • Instituto Tecnológico Pesquero del Perú (ITP), Lima: ITP
    • Instituto Tecnológico Pesquero del Perú (ITP), Laboratorio de Análisis Fisicoquímico. Composición de ácidos grasos por cromatografía de gases. Lima: ITP; 2003.
    • (2003) Composición De Ácidos Grasos Por Cromatografía De Gases
  • 10
    • 53249109525 scopus 로고    scopus 로고
    • Efecto sobre la motilidad intestinal y toxicidad aguda oral del extracto fluido de Ocimun gratissimum L. (orégano cimarrón)
    • Vega R, Carrillo C. Efecto sobre la motilidad intestinal y toxicidad aguda oral del extracto fluido de Ocimun gratissimum L. (orégano cimarrón). Rev Cubana Plant Med. 1997;2(2-3):14-8.
    • (1997) Rev Cubana Plant Med , vol.2 , Issue.2-3 , pp. 14-18
    • Vega, R.1    Carrillo, C.2
  • 11
    • 0344683235 scopus 로고    scopus 로고
    • Institute for Laboratory Animal Research, 8th Ed. Washington, DC: National Academy Press
    • Institute for Laboratory Animal Research. Guide for the care and use of laboratory animals. 8th Ed. Washington, DC: National Academy Press; 2010.
    • (2010) Guide for the Care and Use of Laboratory Animals
  • 13
    • 35648982178 scopus 로고
    • Guideline for the testing of chemicals
    • Organization for Economic Co-operation and Development (OECD), Paris: OECD
    • Organization for Economic Co-operation and Development (OECD). Guideline for the testing of chemicals. Repeated dose 28-day oral toxicity study in rodents 407. Paris: OECD; 1995.
    • (1995) Repeated Dose 28-day Oral Toxicity Study in Rodents 407
  • 16
    • 67349196822 scopus 로고    scopus 로고
    • Supercritical CO2 extraction of omega-3 rich oil from Sacha inchi (Plukenetia volubilis L.) seeds
    • Follegatti-Romero LA, Piantino CR, Grimaldi R, Cabral FA. Supercritical CO2 extraction of omega-3 rich oil from Sacha inchi (Plukenetia volubilis L.) seeds. J Supercrit Fluid. 2009;49(3):323-9.
    • (2009) J Supercrit Fluid , vol.49 , Issue.3 , pp. 323-329
    • Follegatti-Romero, L.A.1    Piantino, C.R.2    Grimaldi, R.3    Cabral, F.A.4
  • 17
    • 0038463560 scopus 로고    scopus 로고
    • Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients
    • Rallidis LS, Paschos G, Liakos GK, Velissaridou AH, Anastasiadis G, Zampelas A. Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. Atherosclerosis. 2003;167(2):237-42.
    • (2003) Atherosclerosis , vol.167 , Issue.2 , pp. 237-242
    • Rallidis, L.S.1    Paschos, G.2    Liakos, G.K.3    Velissaridou, A.H.4    Anastasiadis, G.5    Zampelas, A.6
  • 18
    • 33646917528 scopus 로고    scopus 로고
    • Omega-3 fatty acid intake results in a relationship between the fatty acid composition of LDL cholesterol ester and LDL cholesterol content in humans
    • Clandinin MT, Foxwell A, Goh YK, Layne K, Jumpsen JA. Omega-3 fatty acid intake results in a relationship between the fatty acid composition of LDL cholesterol ester and LDL cholesterol content in humans. Biochim Biophys Acta. 1997;1346(3):247-52.
    • (1997) Biochim Biophys Acta , vol.1346 , Issue.3 , pp. 247-252
    • Clandinin, M.T.1    Foxwell, A.2    Goh, Y.K.3    Layne, K.4    Jumpsen, J.A.5
  • 20
    • 78649435206 scopus 로고    scopus 로고
    • [Tesis para optar el Título de Ingeniero de Industrias Alimentarias]. Lima: Facultad de Industrias Alimentarías, Universidad Nacional Agraria La Molina
    • Mejía M. Extracción y refinación del aceite de sacha inchi. [Tesis para optar el Título de Ingeniero de Industrias Alimentarias]. Lima: Facultad de Industrias Alimentarías, Universidad Nacional Agraria La Molina; 1997.
    • (1997) Extracción Y Refinación Del Aceite De Sacha Inchi
    • Mejía, M.1
  • 21
    • 85020897403 scopus 로고    scopus 로고
    • Asociación de Productores Industriales para la comercialización de productos del sacha inchi (APISI), Lima: APISI
    • Asociación de Productores Industriales para la comercialización de productos del sacha inchi (APISI). Norma técnica del sacha inchi. Lima: APISI; 2010.
    • (2010) Norma Técnica Del Sacha Inchi
  • 22
    • 0142196218 scopus 로고    scopus 로고
    • Conversion of a-linolenic acid to palmitic, palmitoleic, stearic and oleic acid in men and women
    • Burdge GC, Wootton SA. Conversion of a-linolenic acid to palmitic, palmitoleic, stearic and oleic acid in men and women. Prostaglandins Leukot Essent Fatty Acids. 2003;69(4):283-90.
    • (2003) Prostaglandins Leukot Essent Fatty Acids , vol.69 , Issue.4 , pp. 283-290
    • Burdge, G.C.1    Wootton, S.A.2
  • 23
    • 1842765494 scopus 로고    scopus 로고
    • Increasing HDL cholesterol levels
    • Brewer HB. Increasing HDL cholesterol levels. N Engl J Med. 2004;350(15):1491-4.
    • (2004) N Engl J Med , vol.350 , Issue.15 , pp. 1491-1494
    • Brewer, H.B.1
  • 24
    • 17244365543 scopus 로고    scopus 로고
    • Efectos cardiovasculares de los ácidos grasos omega-3 y alternativas para incrementar su ingesta
    • Carrero JJ, Martín-Bautista E, Boró L, Fonollá J, Jiménez J, Boza JJ, et al. Efectos cardiovasculares de los ácidos grasos omega-3 y alternativas para incrementar su ingesta. Nutr Hosp. 2005;20(1):63-9.
    • (2005) Nutr Hosp , vol.20 , Issue.1 , pp. 63-69
    • Carrero, J.J.1    Martín-Bautista, E.2    Boró, L.3    Fonollá, J.4    Jiménez, J.5    Boza, J.J.6
  • 25
    • 33747120160 scopus 로고    scopus 로고
    • n-3 Fatty acids from fish or fish-oil supplements, but not a-linolenic acid, benefit cardiovascular disease outcomes in primary-and secondary-prevention studies: A systematic review
    • Wang Ch, Harris WS, Chung M, Lichtesntein AH, Balk EM, Kupelnick B, et al. n-3 Fatty acids from fish or fish-oil supplements, but not a-linolenic acid, benefit cardiovascular disease outcomes in primary-and secondary-prevention studies: a systematic review. Am J Clin Nutr. 2006;84(1):5-17.
    • (2006) Am J Clin Nutr , vol.84 , Issue.1 , pp. 5-17
    • Wang, C.1    Harris, W.S.2    Chung, M.3    Lichtesntein, A.H.4    Balk, E.M.5    Kupelnick, B.6
  • 26
    • 34548611664 scopus 로고    scopus 로고
    • Alpha-linolenic acid attenuates high glucoseinduced apoptosis in cultured human umbilical vein endothelial cells via PI3K/Akt/eNOS pathway
    • Zhang W, Wang R, Han SF, Bu L, Wang SW, Ma H, et al. Alpha-linolenic acid attenuates high glucoseinduced apoptosis in cultured human umbilical vein endothelial cells via PI3K/Akt/eNOS pathway. Nutrition. 2007;23(10):762-70.
    • (2007) Nutrition , vol.23 , Issue.10 , pp. 762-770
    • Zhang, W.1    Wang, R.2    Han, S.F.3    Bu, L.4    Wang, S.W.5    Ma, H.6
  • 27
    • 0022610655 scopus 로고
    • Estimation of acute oral toxicity in rates by determination of the approximate lethal dose rather than the LD50
    • Kennedy GL, Ferenz RL, Burgess BA. Estimation of acute oral toxicity in rates by determination of the approximate lethal dose rather than the LD50. J Appl Toxicol. 1986;6(3):145-8.
    • (1986) J Appl Toxicol , vol.6 , Issue.3 , pp. 145-148
    • Kennedy, G.L.1    Ferenz, R.L.2    Burgess, B.A.3
  • 29
    • 78649411228 scopus 로고    scopus 로고
    • Decisión 2000/368/CE de la Comisión: Aproximación de las disposiciones legales, reglamentarias y administrativas en materia de clasificación, embalaje y etiquetado de las sustancias peligrosas
    • Unión Europea
    • Unión Europea. Decisión 2000/368/CE de la Comisión: aproximación de las disposiciones legales, reglamentarias y administrativas en materia de clasificación, embalaje y etiquetado de las sustancias peligrosas. Diario Oficial. 2000;L136:108-25.
    • (2000) Diario Oficial , vol.L136 , pp. 108-125


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.