메뉴 건너뛰기




Volumn 23, Issue 10, 2007, Pages 762-770

α-Linolenic acid attenuates high glucose-induced apoptosis in cultured human umbilical vein endothelial cells via PI3K/Akt/eNOS pathway

Author keywords

Linolenic acid; Akt; Apoptosis; Endothelial nitric oxide synthase; Glucose; Human umbilical vein endothelial cell; Phosphatidylinositol 3' kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALBUMIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; LINOLENIC ACID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

EID: 34548611664     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2007.07.003     Document Type: Article
Times cited : (41)

References (34)
  • 1
    • 0035793616 scopus 로고    scopus 로고
    • Mechanisms underlying endothelial dysfunction in diabetes mellitus
    • Hink U., Li H., Mollnau H., Oelze M., Matheis E., Hartmann M., et al. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 88 (2001) E14-E22
    • (2001) Circ Res , vol.88
    • Hink, U.1    Li, H.2    Mollnau, H.3    Oelze, M.4    Matheis, E.5    Hartmann, M.6
  • 2
    • 0036095269 scopus 로고    scopus 로고
    • Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation
    • Ido Y., Carling D., and Ruderman N. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes 51 (2002) 159-167
    • (2002) Diabetes , vol.51 , pp. 159-167
    • Ido, Y.1    Carling, D.2    Ruderman, N.3
  • 3
    • 27844593740 scopus 로고    scopus 로고
    • High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-nB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway
    • Ho F.M., Lin W.W., Chen B.C., Chao C.M., Yang C.R., Lin L.Y., et al. High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-nB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway. Cell Signal 18 (2006) 391-399
    • (2006) Cell Signal , vol.18 , pp. 391-399
    • Ho, F.M.1    Lin, W.W.2    Chen, B.C.3    Chao, C.M.4    Yang, C.R.5    Lin, L.Y.6
  • 4
    • 0034665071 scopus 로고    scopus 로고
    • Endothelial cell apoptosis in angiogenesis and vessel regression
    • Dimmeler S., and Zeiher A.M. Endothelial cell apoptosis in angiogenesis and vessel regression. Circ Res 87 (2000) 434-439
    • (2000) Circ Res , vol.87 , pp. 434-439
    • Dimmeler, S.1    Zeiher, A.M.2
  • 5
    • 0037137299 scopus 로고    scopus 로고
    • Fish consumption, fish oil, ω-3 fatty acids, and CVD
    • Kis-Etherton P.M., Harris W.S., and Appel L.J. Fish consumption, fish oil, ω-3 fatty acids, and CVD. Circulation 106 (2002) 2747-2757
    • (2002) Circulation , vol.106 , pp. 2747-2757
    • Kis-Etherton, P.M.1    Harris, W.S.2    Appel, L.J.3
  • 6
    • 2942548948 scopus 로고    scopus 로고
    • Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies
    • He K., Song Y., Daviglud M.L., Liu K., Van Horn L., Dyer A.R., et al. Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation 109 (2004) 2705-2711
    • (2004) Circulation , vol.109 , pp. 2705-2711
    • He, K.1    Song, Y.2    Daviglud, M.L.3    Liu, K.4    Van Horn, L.5    Dyer, A.R.6
  • 7
    • 0037161373 scopus 로고    scopus 로고
    • Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italino per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione
    • Marchioli R., Barzi F., Bomba E., Chieffo C., Di Gregorio D., Di Mascio R., et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italino per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation 105 (2002) 1897-1903
    • (2002) Circulation , vol.105 , pp. 1897-1903
    • Marchioli, R.1    Barzi, F.2    Bomba, E.3    Chieffo, C.4    Di Gregorio, D.5    Di Mascio, R.6
  • 8
    • 0028235692 scopus 로고
    • Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease
    • de Lorgeril M., Renaud S., Mamelle N., Salen P., Martin J.I., Monjaud I., et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 343 (1994) 1454-1459
    • (1994) Lancet , vol.343 , pp. 1454-1459
    • de Lorgeril, M.1    Renaud, S.2    Mamelle, N.3    Salen, P.4    Martin, J.I.5    Monjaud, I.6
  • 9
    • 0034748162 scopus 로고    scopus 로고
    • Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study
    • Djousse L., Pankow J.S., Eckfeldt J.H., Folsom A.R., Hopkins P.N., Province M.A., et al. Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr 74 (2001) 612-619
    • (2001) Am J Clin Nutr , vol.74 , pp. 612-619
    • Djousse, L.1    Pankow, J.S.2    Eckfeldt, J.H.3    Folsom, A.R.4    Hopkins, P.N.5    Province, M.A.6
  • 10
    • 0032949296 scopus 로고    scopus 로고
    • Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women
    • Hu F.B., Stampfer M.J., Manson J.E., Rimm E.B., Wolk A., Colditz G.A., et al. Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women. Am J Clin Nutr 69 (1999) 890-897
    • (1999) Am J Clin Nutr , vol.69 , pp. 890-897
    • Hu, F.B.1    Stampfer, M.J.2    Manson, J.E.3    Rimm, E.B.4    Wolk, A.5    Colditz, G.A.6
  • 11
    • 20444496148 scopus 로고    scopus 로고
    • Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study
    • Djousse L., Arnett D.K., Carr J.J., Eckfeldt J.H., Hopkins P.N., Province M.A., et al. Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study. Circulation 111 (2005) 2921-2926
    • (2005) Circulation , vol.111 , pp. 2921-2926
    • Djousse, L.1    Arnett, D.K.2    Carr, J.J.3    Eckfeldt, J.H.4    Hopkins, P.N.5    Province, M.A.6
  • 12
    • 33644878048 scopus 로고    scopus 로고
    • Dietary α-linolenic acid intake and risk of sudden cardiac death and coronary heart disease
    • Albert C.M., Oh K., Whang W., Manson J.E., Chae C.U., Stampfer M.J., et al. Dietary α-linolenic acid intake and risk of sudden cardiac death and coronary heart disease. Circulation 112 (2005) 3232-3238
    • (2005) Circulation , vol.112 , pp. 3232-3238
    • Albert, C.M.1    Oh, K.2    Whang, W.3    Manson, J.E.4    Chae, C.U.5    Stampfer, M.J.6
  • 13
    • 0033545884 scopus 로고    scopus 로고
    • Prevention of sudden cardiac death by dietary pure ω-3 polyunsaturated fatty acids in dogs
    • Billman G.E., Kang J.X., and Leaf A. Prevention of sudden cardiac death by dietary pure ω-3 polyunsaturated fatty acids in dogs. Circulation 99 (1999) 2452-2457
    • (1999) Circulation , vol.99 , pp. 2452-2457
    • Billman, G.E.1    Kang, J.X.2    Leaf, A.3
  • 14
    • 0038463560 scopus 로고    scopus 로고
    • Dietary α-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients
    • Rallidis L.S., Paschos G., Lialos G.K., Velissaridou A.H., Anastasiadis G., and Zampelas A. Dietary α-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. Atherosclerosis 167 (2003) 237-242
    • (2003) Atherosclerosis , vol.167 , pp. 237-242
    • Rallidis, L.S.1    Paschos, G.2    Lialos, G.K.3    Velissaridou, A.H.4    Anastasiadis, G.5    Zampelas, A.6
  • 15
    • 0028121061 scopus 로고
    • Comparison of the effects of two diets rich in monounsaturated fatty acids differing in their linoleic/α-linolenic acid ratio on platelet aggregation
    • Freese R., Mutanen M., Valsta L.M., and Salminen I. Comparison of the effects of two diets rich in monounsaturated fatty acids differing in their linoleic/α-linolenic acid ratio on platelet aggregation. Thromb Haemost 71 (1994) 73-77
    • (1994) Thromb Haemost , vol.71 , pp. 73-77
    • Freese, R.1    Mutanen, M.2    Valsta, L.M.3    Salminen, I.4
  • 16
    • 1842474734 scopus 로고    scopus 로고
    • A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial
    • Ros E., Núñez I., Pérez-Heras A., Serra M., Gilabert R., Casals E., and Deulofeu R. A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation 109 (2004) 1609-1614
    • (2004) Circulation , vol.109 , pp. 1609-1614
    • Ros, E.1    Núñez, I.2    Pérez-Heras, A.3    Serra, M.4    Gilabert, R.5    Casals, E.6    Deulofeu, R.7
  • 17
    • 0037373641 scopus 로고    scopus 로고
    • Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus. Effect of omega-3 fatty acids
    • Suresh Y., and Das U.N. Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus. Effect of omega-3 fatty acids. Nutrition 19 (2003) 213-228
    • (2003) Nutrition , vol.19 , pp. 213-228
    • Suresh, Y.1    Das, U.N.2
  • 18
    • 14644419578 scopus 로고    scopus 로고
    • Substituting dietary linoleic acid with alpha-linolenic acid improves insulin sensitivity in sucrose fed rats
    • Ghafoorunissa, Ibrahim A., and Natrajan S. Substituting dietary linoleic acid with alpha-linolenic acid improves insulin sensitivity in sucrose fed rats. Biochim Biophys Acta 1733 (2005) 67-75
    • (2005) Biochim Biophys Acta , vol.1733 , pp. 67-75
    • Ghafoorunissa1    Ibrahim, A.2    Natrajan, S.3
  • 19
    • 0006677050 scopus 로고    scopus 로고
    • Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway
    • Kim I., Kim H.G., So J.N., Kim J.H., Kwak H.J., and Koh G.Y. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Circ Res 86 (2000) 24-29
    • (2000) Circ Res , vol.86 , pp. 24-29
    • Kim, I.1    Kim, H.G.2    So, J.N.3    Kim, J.H.4    Kwak, H.J.5    Koh, G.Y.6
  • 20
    • 0033542414 scopus 로고    scopus 로고
    • Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
    • Fulton D., Gratton J.P., McCabe T.J., Fontana J., Walsh K., Franke T.F., et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 39 (1999) 597-601
    • (1999) Nature , vol.39 , pp. 597-601
    • Fulton, D.1    Gratton, J.P.2    McCabe, T.J.3    Fontana, J.4    Walsh, K.5    Franke, T.F.6
  • 21
    • 0025789802 scopus 로고
    • Biological effects of body fat distribution
    • Malasanos T.H., and Stacpoole P.W. Biological effects of body fat distribution. Diabetes Care 14 (1991) 1160-1179
    • (1991) Diabetes Care , vol.14 , pp. 1160-1179
    • Malasanos, T.H.1    Stacpoole, P.W.2
  • 22
    • 23344439553 scopus 로고    scopus 로고
    • Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival
    • Akbar M., Calderon E., Wen Z., and Kim H.Y. Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. PNAS 102 (2005) 10858-10863
    • (2005) PNAS , vol.102 , pp. 10858-10863
    • Akbar, M.1    Calderon, E.2    Wen, Z.3    Kim, H.Y.4
  • 23
    • 0034612261 scopus 로고    scopus 로고
    • High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH (2)-terminal kinase and caspase-e
    • Ho F.M., Liu S.H., Liau C.S., Huang P.J., and Lin-Shiau S.Y. High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH (2)-terminal kinase and caspase-e. Circulation 101 (2000) 2618-2624
    • (2000) Circulation , vol.101 , pp. 2618-2624
    • Ho, F.M.1    Liu, S.H.2    Liau, C.S.3    Huang, P.J.4    Lin-Shiau, S.Y.5
  • 24
    • 2442492062 scopus 로고    scopus 로고
    • Acute changes in dietary omega-3 fatty acid intake lowers soluble interleukin-6 receptor in healthy adult normal weight and overweight males
    • Nelson T.L., and Hickey M.S. Acute changes in dietary omega-3 fatty acid intake lowers soluble interleukin-6 receptor in healthy adult normal weight and overweight males. Cytokine 26 (2004) 195-201
    • (2004) Cytokine , vol.26 , pp. 195-201
    • Nelson, T.L.1    Hickey, M.S.2
  • 25
    • 19944432698 scopus 로고    scopus 로고
    • Acute effects of monounsaturated fatty acids with and without omega-3 fatty acids on vascular reactivity in individuals with type 2 diabetes
    • West S.G., Hecker K.D., Mustad V.A., Nicholson S., Schoemer S.L., Wagner P., et al. Acute effects of monounsaturated fatty acids with and without omega-3 fatty acids on vascular reactivity in individuals with type 2 diabetes. Diabetologia 48 (2005) 113-122
    • (2005) Diabetologia , vol.48 , pp. 113-122
    • West, S.G.1    Hecker, K.D.2    Mustad, V.A.3    Nicholson, S.4    Schoemer, S.L.5    Wagner, P.6
  • 26
    • 4644243391 scopus 로고    scopus 로고
    • Effect of α-linolenic acid-containing linseed oil on coagulation in type 2 diabetes
    • Tohgi N. Effect of α-linolenic acid-containing linseed oil on coagulation in type 2 diabetes. Diabetes Care 27 (2004) 2563-2564
    • (2004) Diabetes Care , vol.27 , pp. 2563-2564
    • Tohgi, N.1
  • 27
    • 0001880323 scopus 로고    scopus 로고
    • The effect of modified fat diet on insulin resistance and metabolic parameters in type II diabetes
    • Fanaian M., Szilasi J., Storlien L., and Calvert G.D. The effect of modified fat diet on insulin resistance and metabolic parameters in type II diabetes. Diabetologia 39 suppl (1996) A7
    • (1996) Diabetologia , vol.39 , Issue.SUPPL
    • Fanaian, M.1    Szilasi, J.2    Storlien, L.3    Calvert, G.D.4
  • 28
    • 23844549859 scopus 로고    scopus 로고
    • Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses
    • Goyens P.L., Spilker M.E., Zock P.L., Katan M.B., and Mensink R.P. Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses. J Lipid Res 46 (2005) 1474-1483
    • (2005) J Lipid Res , vol.46 , pp. 1474-1483
    • Goyens, P.L.1    Spilker, M.E.2    Zock, P.L.3    Katan, M.B.4    Mensink, R.P.5
  • 29
    • 0037283784 scopus 로고    scopus 로고
    • Interaction of glucose and long chain fatty acids (C18) on antioxidant defences and free radical damage in porcine vascular smooth muscle cells in vitro
    • Hamilton J.S., Powell L.A., McMaster C., and Trimble E.R. Interaction of glucose and long chain fatty acids (C18) on antioxidant defences and free radical damage in porcine vascular smooth muscle cells in vitro. Diabetologia 46 (2003) 106-114
    • (2003) Diabetologia , vol.46 , pp. 106-114
    • Hamilton, J.S.1    Powell, L.A.2    McMaster, C.3    Trimble, E.R.4
  • 30
    • 31944436049 scopus 로고    scopus 로고
    • Saturated, unsaturated, and trans-fatty acids modulate oxidative burst induced by high dextrose in human umbilical vein endothelial cells
    • Horani M.H., Hass M.J., and Mooradian A.D. Saturated, unsaturated, and trans-fatty acids modulate oxidative burst induced by high dextrose in human umbilical vein endothelial cells. Nutrition 22 (2006) 123-127
    • (2006) Nutrition , vol.22 , pp. 123-127
    • Horani, M.H.1    Hass, M.J.2    Mooradian, A.D.3
  • 31
    • 10744224371 scopus 로고    scopus 로고
    • Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells
    • Vecchini A., Ceccarelli V., Susta F., Caligiana P., Orvietani P., Binaglia L., et al. Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells. J Lipid Res 45 (2004) 308-316
    • (2004) J Lipid Res , vol.45 , pp. 308-316
    • Vecchini, A.1    Ceccarelli, V.2    Susta, F.3    Caligiana, P.4    Orvietani, P.5    Binaglia, L.6
  • 32
    • 12644283509 scopus 로고    scopus 로고
    • Cytotoxic action of alpha-linolenic and eicosapentaenoic acids on myeloma cells in vitro
    • Sravan Kumar G., and Das U.N. Cytotoxic action of alpha-linolenic and eicosapentaenoic acids on myeloma cells in vitro. Prostaglandins Leukot Essent Fatty Acids 56 (1997) 285-293
    • (1997) Prostaglandins Leukot Essent Fatty Acids , vol.56 , pp. 285-293
    • Sravan Kumar, G.1    Das, U.N.2
  • 33
    • 21244503501 scopus 로고    scopus 로고
    • Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1
    • Katsuma S., Hatae N., Yano T., Ruike Y., Kimura M., Hirasawa A., and Tsujimoto G. Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1. J Biol Chem 280 (2005) 19507-19515
    • (2005) J Biol Chem , vol.280 , pp. 19507-19515
    • Katsuma, S.1    Hatae, N.2    Yano, T.3    Ruike, Y.4    Kimura, M.5    Hirasawa, A.6    Tsujimoto, G.7
  • 34
    • 0033231839 scopus 로고    scopus 로고
    • Nitric oxide prevents apoptosis of human endothelial cells from high glucose exposure during early stage
    • Ho F.M., Liu S.H., Liau C.S., Huang P.J., Shiah S.G., and Lin-Shiau S.Y. Nitric oxide prevents apoptosis of human endothelial cells from high glucose exposure during early stage. J Cell Biochem 75 (1999) 258-263
    • (1999) J Cell Biochem , vol.75 , pp. 258-263
    • Ho, F.M.1    Liu, S.H.2    Liau, C.S.3    Huang, P.J.4    Shiah, S.G.5    Lin-Shiau, S.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.