Imaging of Nonaccidental Injury and the Mimics: Issues and Controversies in the Era of Evidence-Based Medicine

Radiologic Clinics of North America

Volumn 49, Issue 1, 2011, Pages 205-229

  Barnes, Patrick D ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Child abuse; Evidence based medicine; Nonaccidental head injury; Nonaccidental injury; Nonaccidental trauma

Indexed keywords

ACCIDENTAL INJURY; AIRWAY OBSTRUCTION; BIOMECHANICS; BIRTH INJURY; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN INFECTION; BRAIN INJURY; BRAIN TOXICITY; CHILD; CHILD ABUSE; CHILDBIRTH; CHILDHOOD MORTALITY; CHRONIC DISEASE; CLINICAL PRACTICE; COMPUTER ASSISTED TOMOGRAPHY; CONGENITAL DISORDER; DEVELOPMENTAL DISORDER; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; EVIDENCE BASED MEDICINE; EXPERT WITNESS; FALLING; FORENSIC IDENTIFICATION; GENETIC DISORDER; HUMAN; HYDROCEPHALUS; INJURY; LEGAL LIABILITY; MEDICAL EXPERT; METABOLIC DISORDER; NEUROIMAGING; NEUROPATHOLOGY; NONACCIDENTAL INJURY; NUCLEAR MAGNETIC RESONANCE IMAGING; NUTRITIONAL DEFICIENCY; OCCLUSIVE CEREBROVASCULAR DISEASE; PRACTICE GUIDELINE; PRIORITY JOURNAL; RETINA HEMORRHAGE; REVIEW; SKIN DISEASE; SKULL DISEASE; SUBARACHNOID HEMORRHAGE; SUBARACHNOID SPACE; TRAUMATIC BRAIN INJURY;

ACCIDENTAL FALLS; BATTERED CHILD SYNDROME; BIOMECHANICS; BRAIN; BRAIN INJURIES; CHILD ABUSE; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; EVIDENCE-BASED MEDICINE; EXPERT TESTIMONY; HEMATOMA, SUBDURAL; HUMANS; INFANT; MAGNETIC RESONANCE IMAGING; SHAKEN BABY SYNDROME; TOMOGRAPHY, X-RAY COMPUTED;

EID: 78649397485     PISSN: 00338389     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rcl.2010.08.001     Document Type: Review

References (192)

1. Kleinman P. Diagnostic imaging of child abuse 1998, Mosby Year Book, New York.
2. Frasier L. Abusive head trauma in infants and children 2006, GW Medical Publishing, St Louis (MO).
3. Kellogg N. Committee on child abuse and neglect. Evaluation of suspected child physical abuse. Pediatrics 2007, 119:1232-1241.
4. Barnes P., Krasnokutsky M. Imaging of the CNS in Suspected or Alleged NAI. Top Magn Reson Imaging 2007, 18:53-74.
5. Donohoe M. Evidence-based medicine and shaken baby syndrome part I: literature review, 1966-1998. Am J Forensic Med Pathol 2003, 24:239-242.
6. Leestma J. Case analysis of brain injured admittedly shaken infants, 54 cases 1969-2001. Am J Forensic Med Pathol 2005, 26:199-212.
7. Lyons G. Shaken baby syndrome: a questionable scientific syndrome and a dangerous legal concept. Utah Law Rev 2003, 1109:1-22.
8. Gena M. Shaken baby syndrome: medical uncertaintly casts doubt on convictions. Wis L Rev 2007, 701:1-26.
9. Goudge Hon S.T. Report of the inquiry into pediatric forensic pathology in Ontario. Ontario Ministry of the Attorney General. Queen's Printer for Ontario September 30, 2008, Available at:, Accessed September 12, 2010. http://www.goudgeinquiry.ca.
10. Mackey M. After the court of appeal: R v Harris and others [2005] EWCA crim 1980. Arch Dis Child 2006, 91:873-875.
11. Tuerkheimer D. The next innocence project: shaken baby syndrome and the criminal courts. Wash U L Rev 2009, 87(1):1-58.
12. Squier W. Shaken baby syndrome: the quest for evidence. Dev Med Child Neurol 2008, 50:10-14.
13. David T.J. Non-accidental head injury-the evidence. Pediatr Radiol 2008, 38(Suppl 3):S370-S377.
14. Jaspan T. Current controversies in the interpretation of non-accidental head injury. Pediatr Radiol 2008, 38(Suppl 3):S378-S387.
15. Guyatt, Haynes R.B., Jaeschke R.Z., et al. Users' guides to the medical literature. XXV. Evidence-based medicine. JAMA 2000, 284:1290-1296.
16. Collins J. Evidence-based medicine. J Am Coll Radiol 2007, 4(8):551-554.
17. Blackmore C., Medina L.S. Evidence-based radiology and the ACR appropriateness criteria. J Am Coll Radiol 2006, 3(7):505-509.
18. Crosskerry P. The importance of cognitive errors in diagnosis and strategies to minimize them. Acad Med 2003, 78:775-780.
19. Newman, DH. Physician says medical ideology "gets in the way" of evidence-based medicine. New York Times 4-2-2009; AMA News 4-3-09 [online].
20. Groopman J., Hartzband P. Why 'quality care' is dangerous. Wall St J Available at:, Accessed April 8, 2009. http://wsj.com.
21. Feldman K., Bethel R., Shugerman P., et al. The cause of infant and toddler subdural hemorrhage: a prospective study. Pediatrics 2001, 108:636-646.
22. Hobbs C., Childs A., Wynne J., et al. Subdural haematoma and effusion in infancy: an epidemiological study. Arch Dis Child 2005, 90:952-955.
23. Keierleber J., Bohan T. Ten years after Daubert: the status of the states. J Forensic Sci 2005, 50:1-10.
24. Udashen G, Sperling C. Texas v. Hurtado (Daubert), 2006.
25. DeWolfe C.C. Apparent life-threatening event: a review. Pediatr Clin North Am 2005, 52:1127-1146.
26. Bonkowsky J., Guenther E., Filoux F., et al. Death, child abuse, and adverse neurological outcome of infants after an apparent life-threatening event. Pediatrics 2008, 122:125-131.
27. Uscinski R. Shaken baby syndrome: fundamental questions. Br J Neurosurg 2002, 16:217-219.
28. Ommaya A. Whiplash injury and brain damage. JAMA 1968, 204:75-79.
29. Duhaime A., Gennerelli T., Thibault L., et al. The shaken baby syndrome. A clinical, pathological, and biomechanical study. J Neurosurg 1987, 66:409-415.
30. Prange M., Coats B., Duhaime A., et al. Anthropomorhic simulations of falls, shakes, and inflicted impacts in infants. J Neurosurg 2003, 99:143-150.
31. Forensic neuropathology 2009, 603. CRC Press, Boca Raton (FL). 2nd edition. J. Leestma (Ed.).
32. Pierce M.C., Bertocci G. Injury biomechanics and child abuse. Annu Rev Biomed Eng 2008, 10:85-106.
33. Ommaya A., Goldsmith W., Thibault L. Biomechanics and neuropathology of adult and paediatric head injury. Br J Neurosurg 2002, 16:220-242.
34. Bandak F.A. Shaken baby syndrome: a biomechanics analysis of injury mechanisms. Forensic Sci Int 2005, 151:71-79.
35. Barnes P., Krasnokutsky M., Monson K., et al. Traumatic spinal cord injury: accidental vs. nonaccidental injury. Semin Pediatr Neurol 2008, 15:178-184.
36. Geddes J., Hackshaw A., Vowles G., et al. Neuropathology of inflicted head injury in children. I. Pattern of brain injury. Brain 2001, 124:1290-1298.
37. Geddes J., Vowles G., Hackshaw A., et al. Neuropathology of inflicted head injury in children. II. Microscopic brain injury in infants. Brain 2001, 124:1299-1306.
38. Geddes J., Tasker R., Hackshaw A., et al. Dural haemorrhage in non-traumatic infant deaths: does it explain the bleeding in 'shaken baby syndrome'?. Neuropathol Appl Neurobiol 2003, 29:14-22.
39. Byard R., Blumbergs P., Rutty G., et al. Lack of evidence for a causal relationship between hypoxic-ischemic encephalopathy and subdural hemorrhage in fetal life, infancy, and early childhood. Pediatr Dev Pathol 2007, 10:348-350.
40. Cohen M., Scheimberg I. Evidence of occurrence of intradural and subdural hemorrhage in the perinatal and neonatal period in the context of hypoxic ischemic encephalopathy. Pediatr Dev Pathol 2009, 12:169-176.
41. Croft P., Reichard R. Microscopic examination of grossly unremarkable pediatric dura mater. Am J Forensic Med Pathol 2009, 30:10-13.
42. Emerson M., Pieramici D., Stoessel K., et al. Incidence and rate of disappearance of retinal hemorrhage in newborns. Ophthalmology 2001, 108:36-39.
43. Chadwick D., Bertocci G., Castillo E., et al. Annual risk of death resulting from short falls among children. Pediatrics 2008, 121:1213-1224.
44. Hall J., Reyes H., Horvat M., et al. The mortality of childhood falls. J Trauma 1989, 29:1273-1275.
45. Chadwick D., Chin S., Salerno C., et al. Deaths from falls in children: how far is fatal. J Trauma 1991, 31:1335.
46. Helfer R., Slovis T., Black M. Injuries resulting when small children fall out of bed. Pediatrics 1977, 60:533-535.
47. Reiber G. Fatal falls in childhood. Am J Forensic Med Pathol 1993, 14:201-207.
48. Williams R. Injuries in infants and small children resulting from witnessed and corroborated free falls. J Trauma 1991, 31:1350-1352.
49. Lyons T., Oates R. Falling out of bed: a relatively benign occurrence. Pediatrics 1993, 92:125-127.
50. Oehmichen M., Meissner C., Saternus K. Fall or shaken: traumatic brain injury in children caused by falls or abuse at home-a review on biomechanics and diagnosis. Neuropediatrics 2005, 36:240-245.
51. Duhaime A., Alario A., Lewander W., et al. Head injury in very young children: mechanisms, injury types, and ophthalmologic findings in 100 hospitalized patients younger than 2 years of age. Pediatrics 1992, 90:179-185.
52. Schutzman S.A., Barnes P.D., Duhaime A.-C., et al. Evaluation and management of children younger than two years old with apparently minor head trauma: proposed guidelines. Pediatrics 2001, 107:983-993.
53. Stein S., Spettell C. Delayed and progressive brain injury in children and adolescents with head trauma. Pediatr Neurosurg 1995, 23:299-304.
54. Bruce D. Delayed deterioration of consciousness after trivial head injury in childhood. Br Med J (Clin Res Ed) 1984, 289:715-716.
55. Bruce D., Alavi A., Bilaniuk L., et al. Diffuse cerebral swelling following head injuries in children: the syndrome of malignant brain edema. J Neurosurg 1981, 54:170-178.
56. Plunkett J. Fatal pediatric head injuries caused by short-distance falls. Am J Forensic Med Pathol 2001, 22:1-12.
57. Greenes D., Schutzman S. Occult intracranial trauma in infants. Ann Emerg Med 1998, 32:680-686.
58. Arbogast K., Margulis S., Christian C. Initial neurologic presentation in young children sustaining inflicted and unintentional fatal head injuries. Pediatrics 2005, 116:180-184.
59. Denton S., Mileusnic D. Delayed sudden death in an infant following an accidental fall. Am J Forensic Med Pathol 2003, 24:371-376.
60. Murray J., Chen D., Velmahos G., et al. Pediatric falls: is height a predictor of injury and outcome?. Am Surg 2000, 66:863-865.
61. Kim K., Wang M., Griffith P., et al. Analysis of pediatric head injury falls. Neurosurg Focus 2000, 8:1-9.
62. Steinbok P., Singhal A., Poskitt K., et al. Early hypodensity on CT scan of the brain in accidental pediatric head injury. Neurosurgery 2007, 60:689-695.
63. Christian C.W., Taylor A.A., Hertle R.W., et al. Retinal hemorrhages caused by accidental household trauma. J Pediatr 1999, 135:125-127.
64. Durham S.R., Duhaime A.-C. Maturation-dependent response of the immature brain to experimental subdural hematoma. J Neurotrauma 2007, 24:5-14.
65. Azais M., Echenne B. Idiopathic pericerebral effusions of infancy (external hydrocephalus). Annales Pediatr (Paris) 1992, 39:550-558.
66. Piatt J. A pitfall in the diagnosis of child abuse: external hydrocephalus, subdural hematoma, and retinal hemorrhages. Neurosurg Focus 1999, 7(4):1-8.
67. Pittman T. Significance of subdural hematoma in a child with external hydrocephalus. Pediatr Neurosurg 2003, 39:57-59.
68. Papasian N., Frim D. A theoretical model of benign external hydrocephalus that predicts a predisposition towards extra-axial hemorrhage after minor head trauma. Pediatr Neurosurg 2000, 33:188-193.
69. Hangique S., Das R., Barua N., et al. External hydrocephalus in children. Ind J Radiol Imag 2002, 12:197-200.
70. Mori K., Sakamoto T., Mishimura K., et al. Subarachnoid fluid collection in infants complicated by subdural hematoma. Childs Nerv Syst 1993, 9:282-284.
71. Ravid S., Maytal J. External hydrocephalus: a probable cause for subdural hematoma of infancy. Pediatr Neurol 2003, 28:139-141.
72. McNeely P.D., Atkinson J.D., Saigal G., et al. Subdural hematomas in infants with benign enlargement of the subarachnoid spaces are not pathognomonic for child abuse. Am J Neuroradiol 2006, 27:1725-1728.
73. Hellbusch L. Benign extracerebral fluid collections in infancy: clinical presentation and long-term follow-up. J Neurosurg 2007, 107:119-125.
74. Mori K., Yamamoto T., Horinaka N., et al. Arachnoid cyst is a risk factor for chronic subdural hematoma in juveniles. J Neurotrauma 2002, 19:1017-1027.
75. Chamnanvanakij S., Rollins N., Perlman J. Subdural hematoma in term infants. Pediatr Neurol 2002, 26:301-304.
76. Whitby E., Griffiths P., Rutter S., et al. Frequency and natural history of subdural hemorrhages in babies and relation to obstetric factors. Lancet 2004, 363:846-851.
77. Hayashi T., Hashimoto T., Fukuda S., et al. Neonatal subdural hematoma secondary to birth injury. Childs Nerv Syst 1987, 3:23-29.
78. Rooks V., Eaton J., Ruess L., et al. Prevalence and evolution of intracranial hemorrhage in asymptomatic term infants. AJNR Am J Neuroradiol 2008, 29:1082-1089.
79. Volpe J.J. Neurology of the newborn 2000, WB Saunders, Philadelphia. 4th edition.
80. Ney J., Joseph K., Mitchell M. Late subdural hygromas from birth trauma. Neurology 2005, 65:517.
81. Holden K., et al. Cranial MRI of normal term neonates: a pilot study. J Child Neurol 1999, 14:708-710.
82. Looney C., Smith J., Merck L., et al. Intracranial hemorrhage in asymptomatic neonates: prevalence on MRI and relationship to obstetric and neonatal risk factors. Radiology 2007, 242:535-541.
83. Powers C., Fuchs H., George T. Chronic subdural hematoma of the neonate. Pediatr Neurosurg 2007, 43:25-28.
84. Ross M., Fresquez M., El-Hacklad M. Impact of FDA advisory on reported vacuum-assisted delivery and morbidity. J Matern Fetal Med 2000, 9:321-326.
85. Towner D., Castro M., Eby-Wilkens E., et al. Effect of mode of delivery in nulliparous women on neonatal intracranial injury. N Engl J Med 1999, 341:1709-1714.
86. Polina J, Dias M, Kachurek D, et al. Cranial birth injuries in term newborn infants. Pediatr Neurosurg 2001;35:113-9.
87. Alexander J., Leveno K., Hauth J., et al. Fetal injury associated with cesarean delivery. Obstet Gynecol 2006, 108:885-890.
88. Doumouchtsis S., Arulkumaran S. Head trauma after instrumental births. Clin Perinatol 2008, 35:69-83.
89. Sirotnak A. Medical disorders that mimic abusive head trauma. Abusive head trauma in infants and children 2006, GW Medical Publishing, St Louis (MO), p. 191-226. L. Frasier (Ed.).
90. Mack J., Squier W., Eastman J. Anatomy and development of the meninges: implications for subdural collections and cerebrospinal fluid circulation. Pediatr Radiol 2009, 39:200-210.
91. Haines D., Harkey H., Al-Mefty O. The subdural space: a new look at an outdated concept. Neurosurgery 1993, 32:111-120.
92. Kawakami Y., Chikama M., Tamiya T., et al. Coagulation and fibrinolysis in chronic subdural hematoma. Neurosurgery 1998, 25:25-29.
93. Murakami H., Hirose Y., Sagoh M., et al. Why do chronic subdura hematomas continue to grow slowly and not coagulate?. J Neurosurg 2002, 96:877-884.
94. Parent A.D. Pediatric chronic subdural hematoma. A retrospective comparative analysis. Pediatr Neurosurg 1992, 18:266-271.
95. Hwang S., Kim S. Infantile head injury, with special reference to the development of chronic subdural hematoma. Child's Nerv Syst 2000, 16:590-594.
96. Fung E., Sung R.Y., Nelson E.A., et al. Unexplained subdural hematoma in young children: is it always child abuse. Pediatr Int 2002, 44:37-42.
97. Aoki N., Masuzawa H. Infantile acute subdural hematoma. J Neurosurg 1984, 61:273-280.
98. Aoki N. Chronic subdural hematoma in infancy. J Neurosurg 1990, 73:201-205.
99. Ikeda A., Sato O., Tsugane R., et al. Infantile acute subdural hematoma. Child's Nerv Syst 1987, 3:19-22.
100. Dyer O. Brain haemorrhage in babies may not indicate violent abuse. BMJ 2003, 326:616.
101. Hymel K., Jenny C., Block R. Intracranial hemorrhage and rebleeding in suspected victims of abusive head trauma: addressing the forensic controversies. Child Maltreat 2002, 7:329-348.
102. Howard M., Bell B., Uttley D. The pathophysiology of infant subdural haematomas. Br J Neurosurg 1993, 7:355-365.
103. Vinchon M., Noizet O., Defoort-Dhellemmes S., et al. Infantile subdural hematomas due to traffic accidents. Pediatr Neurosurg 2002, 37:245-253.
104. Vinchon M., Noule N., Tchofo P., et al. Imaging of head injuries in infants: temporal correlates and forensic implications for the diagnosis of child abuse. J Neurosurg 2004, 101:44-52.
105. Maxeiner H. Demonstration and interpretation of bridging vein ruptures in cases of infantile subdural bleeding. J Forensic Sci 2001, 46:85-93.
106. Minns R. Subdural haemorrhages, haematomas, and effusions of infancy. Arch Dis Child 2005, 90:883-884.
107. Hobbs C., Childs A., Wynne J., et al. Subdural haematoma and effusion in infancy. Arch Dis Child 2005, 90:952-955.
108. Datta S., Stoodley N., Jayawant S., et al. Neuroradiological aspects of subdural haemorrhages. Arch Dis Child 2005, 90:947-951.
109. Kemp A. Investigating subdural haemorrhage in infants. Arch Dis Child 2002, 86:98-102.
110. Jayawant S., Rawlinson A., Gibbon F., et al. Subdural haemorrhages in infants: population based study. BMJ 1998, 317:1558-1561.
111. Jayawant S., Parr J. Outcome following subdural haemorrhages in infancy. Arch Dis Child 2007, 92:343-347.
112. Trenchs V., Curcoy A., Navarro R., et al. Subdural haematomas and physical abuse in the first two years of life. Pediatr Neurosurg 2007, 43:352-357.
113. Galaznik J. Eye findings and allegations of shaking and non-accidental injury: post-publication peer review (8 August 2007). Pediatrics 2007, 19:1232-1241.
114. Galaznik J. Shaken baby syndrome: letter to the editor. Dev Med Child Neurol 2008, 50:317-319.
115. Levin A., Wygnanski-Jaffe T., Shafiq A., et al. Postmortem orbital findings in shaken baby syndrome. Am J Ophthalmol 2006, 142:233-240.
116. Morad Y., Kim Y., Armstrong D., et al. Correlation between retinal abnormalities and intracranial abnormalities in the shaken baby syndrome. Am J Ophthalmol 2002, 134:354-359.
117. Kirshner R., Stein R. The mistaken diagnosis of child abuse. A form of medical abuse?. Am J Dis Child 1985, 139:873-875.
118. Tongue A. The ophthalmologists role in diagnosing child abuse. Ophthalmology 1991, 98:1009-1010.
119. Gardner H. Correlation between retinal abnormalities and intracranial abnormalities in the shaken baby syndrome. Am J Ophthalmol 2003, 135:745-746.
120. Gilles E., McGregor M., Levy-Clarke G. Retinal hemorrhage asymmetry in inflicted head injury: a clue to pathogenesis?. J Pediatr 2003, 143:494-499.
121. Gilliland M., Luthert P. Why do histology on retinal hemorrhages in suspected nonaccidental injury. Histopathology 2003, 43:592-602.
122. Lantz P., Sinal S., Staton C., et al. Perimacular retinal folds from childhood head trauma: evidence-based case report. BMJ 2004, 328:754-756.
123. Aryan H., Ghosheh F., Jandial R., et al. Retinal hemorrhage and pediatric brain injury: etiology and review of the literature. J Clin Neurosci 2005, 12:624-631.
124. Lueder G.T., Turner J.W., Paschall R. Perimacular retinal folds simulating nonaccidental injury in an infant. Arch Ophthalmol 2006, 124:1782-1783.
125. Obi E., Watts P. Are there any pathognomonic signs in shaken baby syndrome. J AAPOS 2007, 11:99-100.
126. Forbes B., Cox M., Christian C. Retinal hemorrhages in patients with epidural hematomas. J AAPOS 2008, 12:177-180.
127. Binenaum G., Forbes B., Raghupathi R., et al. An animal model to study retinal hemorrhages in nonimpact brain injury. J AAPOS 2007, 11:84-85.
128. Brown S., Levin A., Ramsey D., et al. Natural animal shaking: a model for inflicted neurotrauma in children?. J AAPOS 2007, 11:85-86.
129. Emerson M.V., Jakobs E., Green W.R. Ocular autopsy and histopathologic features of child abuse. Ophthalmology 2007, 114:1384-1394.
130. Gardner H. Retinal folds. Arch Ophthalmol 2007, 125:1142.
131. Lantz PE. Postmortem detection and evaluation of retinal hemorrhages. Abstract, presented at the AAFS Annual meeting. Seattle, Washington, February, 2006. Am Acad Forens Sci 2006.
132. Goldsmith W., Plunkett J. Biomechanical analysis of the causes of traumatic brain injury in infants and children. Am J Forensic Med Pathol 2004, 25:89-100.
133. Jenny C. Committee on Child Abuse and Neglect. Evaluating infants and young children with multiple fractures. Pediatrics 2006, 118:1299-1303.
134. Bishop N., et al. Unexplained fractures in infancy: looking for fragile bones. Arch Dis Child 2007, 92:251-256.
135. Kleinman P. Problems in the diagnosis of metaphyseal fractures. Pediatr Radiol 2008, 38(Suppl 3):S388-S394.
136. Keller K., Barnes P. Rickets vs. abuse: a national and international epidemic. Pediatr Radiol 2008, 38:1210-1216.
137. Keller KA, Barnes PD. Rickets vs. abuse - the evidence: reply to editorial commentaries. Pediatr Radiol 2009;39:1130.
138. Ganesh A., Jenny C., Geyer J., et al. Retinal hemorrhages in type I osteogenesis imperfecta after minor trauma. Ophthalmology 2004, 111:1428-1431.
139. Groninger A., Schaper J., Messing-Juenger M., et al. Subdural hematoma as clinical presentation of osteogenesis imperfecta. Pediatr Neurol 2005, 32:140-142.
140. Strauss K., Puffenberger E., Robinson D., et al. Type I glutaric aciduria, part 1: natural history of 77 patients. Semin Med Genet 2003, 121C:38-52.
141. Nassogne M.C., Sharrad M., Hertz-Pannier L., et al. Massive subdural haematomas in Menkes disease mimicking shaken baby syndrome. Childs Nerv Syst 2002, 18:729-731.
142. Ernst L., Sondheimer N., Deardorff M., et al. The value of the metabolic autopsy in the pediatric hospital setting. J Pediatr 2006, 148:779-783.
143. Brousseau T., Kissoon N., McIntosh B. Vitamin K deficiency mimicking child abuse. J Emerg Med 2005, 29:283-288.
144. Rooms L., Fitzgerald N., McClain K.L. Hemophagocytic lymphohistiocytosis masquerading as child abuse. Pediatrics 2003, 111:636-640.
145. Liesner R., Hann I., Khair K. Non-accidental injury and the haematologist: the causes and investigation of easy bruising. Blood Coagul Fibrinolysis 2004, 15(Suppl 1):S41-S48.
146. Roach E., Golomb M., Adams R., et al. Management of stroke in infants and children. Stroke 2008, 39:2644-2691.
147. Carvalho K.S., Bodensteiner J.B., Connolly P.J., et al. Cerebral venous thrombosis in children. J Child Neurol 2001, 16:574-585.
148. Fitzgerald K.C., Williams L.S., Garg B.P., et al. Cerebral sinovenous thrombosis in the neonate. Arch Neurol 2006, 63:405-409.
149. DeVeber G., Andrew M., Group C.P.I.S.S. Cerebral sinovenous thrombosis in children. N Engl J Med 2001, 345:417-423.
150. Barnes C., deVeber G. Prothrombotic abnormalities in childhood ischaemic stroke. Thromb Res 2006, 118:67-74.
151. Sebire G., Tabarki B., Saunders D., et al. Cerebral venous sinus thrombosis in children: risk factors, presentation, diagnosis, and outcome. Brain 2005, 128:477-489.
152. Krasnokutsky M., Barnes P. Cerebral venous thrombosis: a mimic of nonaccidental injury. Scientific Paper Session 2007, Society for Pediatric Radiology, Miami (FL).
153. Menge T., Hemmer B., Nessler S., et al. Acute disseminated encephalomyelitis. An update. Arch Neurol 2005, 62:1673-1680.
154. Moritani T., Smoker W., Sato Y., et al. Diffusion-weighted imaging of acute excitotoxic brain injury. AJNR Am J Neuroradiol 2005, 26:216-228.
155. Yazbak F. Multiple vaccinations and the shaken baby syndrome. National Vaccine Information Center. The Vaccine Adverse Event Reporting System (VAERS) of the Center for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) Available at:, Accessed September 12, 2010. http://www.nvic.org/doctors_corner/ed_yazbak_shaken-baby_syndrome.htm.
156. Innis M. Vaccines, apparent life-threatening events, Barlow's disease, and questions about Shaken baby syndrome. J Am Phys Surg 2006, 11:17-19.
157. Clemetson C.A. Is it "shaken baby," or Barlow's disease variant?. J Am Phys Surg 2004, 9:78-80.
158. Clemetson C.A. Caffey revisited: a commentary on the origin of "shaken baby syndrome" J Am Phys Surg 2006, 11:20-21.
159. Marinetti L., Lehman L., Casto B., et al. Over-the-counter cold medications-postmortem findings in infants and the relationship to cause of death. J Anal Toxicol 2005, 29:738-743.
160. Geddes J., Talbert D. Paroxysmal coughing, subdural, and retinal bleeding: a computer modeling approach. Neuropathol Appl Neurobiol 2006, 32:625-634.
161. Talbert D. The sutured skull and intracranial bleeding in infants. Med Hypotheses 2006, 66:691-694.
162. American Academy of Pediatrics red book online Pertussis Available at:, Accessed September 12, 2010. http://www.aapredbook.aappublications.org/cgi/content/full/2003/1/3.9.
163. Surridge J., Segedin E., Grant C. Pertussis requiring intensive care. Arch Dis Child 2007, 92:970-975.
164. CDC National Immunization Program General pertussis information. 2000:2. Available at:, Accessed September 12, 2010. http://www.cdc.gov/doc.do/id/0900f3ec80228696.
165. Page M., Jeffery H. The role of gastro-oesophageal reflux in the aetiology of SIDS. Early Hum Dev 2000, 59:127-149.
166. Mohan P. Aspiration in infants and children. Pediatr Rev 2002, 23:330-331.
167. Barnes P., Galaznik J., Krasnokutsky M., et al. CT in infant dysphagic choking acute life threatening event (ALTE - a mimic of child abuse). Scientific Session 2008, Society for Pediatric Radiology, Scottsdale (AZ).
168. Zimmerman R.A., Bilaniuk L.T., Bruce D., et al. Interhemispheric acute subdural hematoma. A computed tomographic manifestation of child abuse by shaking. Neuroradiology 1979, 16:39-40.
169. Cohen R.A., Kaufman R.A., Myers P.A., et al. Cranial computed tomography in the abused child with head injury. AJNR Am J Neuroradiol 1985, 6:883-888.
170. Bird C.R., McMahan J.R., Gilles R.H., et al. Strangulation in child abuse: CT diagnosis. Radiology 1987, 163:373-375.
171. Hymal K.P., Rumack C.M., Hay T.C., et al. Comparison of intracranial CT findings in pediatric abusive and accidental head trauma. Pediatr Radiol 1997, 27:743-747.
172. Ewings-Cobbs L., Prasad M., Kramer L., et al. Acute neuroradiologic findings in young children with inflicted or noninflicted traumatic brain injury. Childs Nerv Syst 2000, 16:25-33.
173. Barnes P.D., Robson C.D. CT findings in hyperacute nonaccidental brain injury. Pediatr Radiol 2000, 30:74-81.
174. Wells R., Vetter C., Laud P. Intracranial hemorrhage in children younger than 3 years. Arch Pediatr Adolesc Med 2002, 156:252-257.
175. Wells R., Sty J. Traumatic low attenuation subdural fluid collections in children younger than 3 years. Arch Pediatr Adolesc Med 2003, 157:1005-1010.
176. Stoodley N. Neuroimaging in non-accidental head injury: if, when, why and how. Clin Radiol 2005, 60:22-30.
177. Duhaime A.C., Christian C., Armonda R., et al. Disappearing subdural hematomas in children. Pediatr Neurosurg 1996, 25(3):116-122.
178. Tung G.A., Kumar M., Richardson R.C., et al. Comparison of accidental and nonaccidental traumatic head injury in children on noncontrast computed tomography. Pediatrics 2006, 118(2):626-633.
179. Slovis T.L., Smith W.L., Strain J.D., et al. Expert panel on pediatric imaging. Suspected physical abuse-child 2005, American College of Radiology (ACR), Reston (VA), [online].
180. Di Pietro M.A., Brody A.S., Cassady C.I., et al. for Section on Radiology; American Academy of Pediatrics. Diagnostic imaging of child abuse. Pediatrics 2009, 123:1430-1435.
181. Vezina G. Assessment of the nature and age of subdural collections in nonaccidental head injury with CT and MRI. Pediatr Radiol 2009, 39:586-590.
182. Ewing-Cobbs L., Kramer L., Prasad M., et al. Neuroimaging, physical, and developmental findings after inflicted and non-inflicted traumatic brain injury in young children. Pediatrics 1998, 102:300-307.
183. Rooks V.J., Sisler C., Burton B. Cervical spine injury in child abuse: report of two cases. Pediatr Radiol 1998, 28:193-195.
184. Chabrol B., Decarie J.C., Fortin G. The role of cranial MRI in identifying patients suffering from child abuse and presenting with unexplained neurological findings. Child abuse Negl 1999, 23:217-228.
185. Barlow K.M., Gibson R.J., PcPhillips M., et al. Magnetic resonance imaging in acute nonaccidental head injury. Acta Pediatr 1999, 88:734-740.
186. Suh D., Davis P., Hopkins K., et al. Non-accidental pediatric head injury: diffusion-weighted imaging findings. Neurosurgery 2001, 49:309-320.
187. Ichord R., Naim M., Pollack A., et al. Hypoxic-ischemic injury complicates inflicted and accidental traumatic brain injury in young children: the role of diffusion-weighted imaging. J Neurotrauma 2007, 24:106-118.
188. Zuerrer M., Martin E., Boltshauser E. MRI of intracranial hemorrhage in neonates and infants at 2.35 Tesla. Neuroradiology 1991, 33:223-229.
189. Barkovich A. Pediatric neuroimaging 2005, Lippincott-Raven, Philadelphia, p. 190-290.
190. Barnes P. Pediatric brain imaging. Pediatric radiology: the requisites 2009, Elsevier, Philadelphia, p. 221-7. 3rd edition. J. Blickman, B. Parker, P. Barnes (Eds.).
191. Zouros A., Bhargava R., Hoskinson M., et al. Further characterization of traumatic collections of infancy. J Neurosurg 2004, 100:512-518.
192. Fullerton H.J., Johnston S.C., Smith W.S. Arterial dissection and stroke in children. Neurology 2001, 57:1155-1160.