Osteoprotective effects of Fructus Ligustri Lucidi aqueous extract in aged ovariectomized rats

Chinese Medicine

Volumn 5, Issue , 2010, Pages

  Ko, Chun H ^a   Siu, Wing S ^a   Lau, Ching P ^a   Lau, Clara Bik S ^a   Fung, Kwok P ^a   Leung, Ping C ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; LIGUSTRUM LUCIDUM EXTRACT; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; RALOXIFENE; WATER;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; BONE DENSITY; BONE DEVELOPMENT; CALCIFICATION; CELL COUNT; CELL DIFFERENTIATION; CHEMICAL ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; CYTOTOXICITY; DOSE RESPONSE; DRUG MEGADOSE; ENZYME ACTIVITY; FEMALE; LUMBAR SPINE; MESENCHYMAL STEM CELL; NONHUMAN; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY; POSTMENOPAUSE; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPINE SCINTISCANNING; STAINING; TRABECULAR BONE; UTERUS WEIGHT;

EID: 78649376397     PISSN: None     EISSN: 17498546     Source Type: Journal    
DOI: 10.1186/1749-8546-5-39     Document Type: Article

References (25)

1. Li ML. Progress in the study on Fructus Ligustri Lucidi. Zhongguo Zhong Yao Za Zhi 1994, 19(8):504-6.
2. Sun Y, Lee SM, Wong YM, Lau CP, Shaw PC, Qin L, Leung PC, Fung KP. Dose effects of an antiosteoporosis herbal formula - a preclinical investigation using a rat model. Phytother Res 2008, 22(2):267-73. 10.1002/ptr.2291, 17726734.
3. Zhang Y, Lai WP, Leung PC, Wu CF, Yao XS, Wong MS. Effects of Fructus Ligustri Lucidi extract on bone turnover and calcium balance in ovariectomized rats. Biol Pharm Bull 2006, 29(2):291-6. 10.1248/bpb.29.291, 16462034.
4. Zhang Y, Leung PC, Che CT, Chow HK, Wu CF, Wong MS. Improvement of bone properties and enhancement of mineralization by ethanol extract of Fructus Ligustri Lucidi. Br J Nutr 2008, 99(3):494-502. 10.1017/S0007114507801589, 17764596.
5. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997, 276(5309):71-4. 10.1126/science.276.5309.71, 9082988.
6. Nuttall ME, Gimble JM. Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol 2004, 4(3):290-4. 10.1016/j.coph.2004.03.002, 15140422.
7. Fu L, Tang T, Miao Y, Zhang S, Qu Z, Dai K. Stimulation of osteogenic differentiation and inhibition of adipogenic differentiation in bone marrow stromal cells by alendronate via ERK and JNK activation. Bone 2008, 43(1):40-7. 10.1016/j.bone.2008.03.008, 18486585.
8. Chinese Pharmacopoeia Commission Chinese Pharmacopoeia 2010, Beijing: Chemical Industry Publishing House, Chinese Pharmacopoeia Commission.
9. Nordin BE. Calcium and osteoporosis. Nutrition 1997, 13(4-8):664-86. 10.1016/S0899-9007(97)83011-0, 9263260.
10. Dobson KR, Reading L, Haberey M, Marine X, Scutt A. Centrifugal isolation of bone marrow from bone: an improved method for the recovery and quantitation of bone marrow osteoprogenitor cells from rat tibiae and femurae. Calcif Tissue Int 1999, 65(5):411-3. 10.1007/s002239900723, 10541770.
11. Heim M, Frank O, Kampmann G, Sochocky N, Pennimpede T, Fuchs P, Hunziker W, Weber P, Martin I, Bendik I. The phytoestrogen genistein enhances osteogenesis and represses adipogenic differentiation of human primary bone marrow stromal cells. Endocrinology 2004, 145(2):848-59. 10.1210/en.2003-1014, 14605006.
12. Neubauer M, Fischbach C, Bauer-Kreisel P, Lieb E, Hacker M, Tessmar J, Schulz MB, Goepferich A, Blunk T. Basic fibroblast growth factor enhances PPARgamma ligand-induced adipogenesis of mesenchymal stem cells. FEBS Lett 2004, 577(1-2):277-83. 10.1016/j.febslet.2004.10.020, 15527799.
13. Li G, Zhang XA, Zhang JF, Chan CY, Yew DT, He ML, Lin MC, Leung PC, Kung HF. Ethanol extract of Fructus Ligustri Lucidi promotes osteogenesis of mesenchymal stem cells. Phytother Res 2010, 24(4):571-6.
14. Boyce BF, Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys 2008, 473(2):139-46. 10.1016/j.abb.2008.03.018, 2413418, 18395508.
15. Boyce BF, Xing L. The RANKL/RANK/OPG pathway. Curr Osteoporos Rep 2007, 5(3):98-104. 10.1007/s11914-007-0024-y, 17925190.
16. Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Spelsberg TC, Riggs BL. Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells. Endocrinology 1999, 140(9):4367-70. 10.1210/en.140.9.4367, 10465311.
17. Fitzpatrick LA. Estrogen therapy for postmenopausal osteoporosis. Arq Bras Endocrinol Metabol 2006, 50(4):705-19.
18. Krieger N, Löwy I, Aronowitz R, Bigby J, Dickersin K, Garner E, Gaudillière JP, Hinestrosa C, Hubbard R, Johnson PA, Missmer SA, Norsigian J, Pearson C, Rosenberg CE, Rosenberg L, Rosenkrantz BG, Seaman B, Sonnenschein C, Soto AM, Thornton J, Weisz G. Hormone replacement therapy, cancer, controversies, and women's health: historical, epidemiological, biological, clinical, and advocacy perspectives. J Epidemiol Community Health 2005, 59(9):740-8. 10.1136/jech.2005.033316, 1733142, 16100311.
19. Teede HJ. The menopause and HRT. Hormone replacement therapy, cardiovascular and cerebrovascular disease. Best Pract Res Clin Endocrinol Metab 2003, 17(1):73-90. 10.1016/S1521-690X(02)00083-0, 12763513.
20. Marshall JK. The gastrointestinal tolerability and safety of oral bisphosphonates. Expert Opin Drug Saf 2002, 1(1):71-8. 10.1517/14740338.1.1.71, 12904162.
21. Arum SM. New developments surrounding the safety of bisphosphonates. Curr Opin Endocrinol Diabetes Obes 2008, 15(6):508-13.
22. Fan QH, Hou YL, Zhu AH, Lu LX, Feng JQ. Comparising the effects of different preparations of Fructus Ligustri Lucidi on enhancing white blood cell and anti-hypoxia ability. Chi Pharm J 2004, 19(1):20-21.
23. Adams JE. Quantitative computed tomography. Eur J Radiol 2009, 71(3):415-24. 10.1016/j.ejrad.2009.04.074, 19682815.
24. Lalla S, Hothorn LA, Haag N, Bader R, Bauss F. Lifelong administration of high doses of ibandronate increases bone mass and maintains bone quality of lumbar vertebrae in rats. Osteoporos Int 1998, 8(2):97-103. 10.1007/BF02672503, 9666930.
25. Ferretti JL, Capozza RF, Zanchetta JR. Mechanical validation of a tomographic (pQCT) index for noninvasive estimation of rat femur bending strength. Bone 1996, 18(2):97-102. 10.1016/8756-3282(95)00438-6, 8833202.