Molecular pathogenesis of helicobacter pylori infection: The role of bacterial virulence factors

Digestive Diseases

Volumn 28, Issue 4-5, 2010, Pages 604-608

  Molnar, Bela ^a   Galamb, Orsolya ^a   Sipos, Ferenc ^a   Leiszter, Katalin ^a   Tulassay, Zsolt ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Adherence; Epithelia; Helicobacter pylori infection; Immune response; Molecular biology

Indexed keywords

AGING; BACTERIAL COLONIZATION; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; CELL FUNCTION; CELL INTERACTION; CONFERENCE PAPER; EPITHELIUM CELL; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOCOMPETENT CELL; MOLECULAR BIOLOGY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; STOMACH ACID; STOMACH MUCOSA; STOMACH ULCER;

AGING; ANIMALS; EPITHELIAL CELLS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HOST-PATHOGEN INTERACTIONS; HUMANS; VIRULENCE FACTORS;

EID: 78649368029     PISSN: 02572753     EISSN: None     Source Type: Journal    
DOI: 10.1159/000320060     Document Type: Conference Paper

References (26)

1. Eaton KA, Krakowka S: Effect of gastric pH on urease-dependent colonization of gnoto-biotic piglets by Helicobacter pylori. Infect Immun. 1994; 62 : 3604-3607.
2. Wang G, Ge Z, Rasko DA, Taylor DE: Lewis antigens in Helicobacter pylori: biosynthesis and phase variation. Mol Microbiol 2000; 36: 1187-1196.
3. Perez-Perez GI, Shepherd VL, Morrow JD, Blaser MJ: Activation of human THP-1 cells and rat bone marrow-derived macrophages by Helicobacter pylori lipopolysaccharide. Infect Immun 1995; 63:1183-1187.
4. Censini S, Lange C, Xiang Z, Crabtree JE, Ghiara P, Borodovsky M, Rappuoli R, Co-vacci A: cag, a pathogenicity island of Helico-bacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Nat l Acad Sci USA 1996; 93: 14648-14653.
5. Clyne M, Dolan B, Reeves EP: Bacterial factors that mediate colonization of the stomach and virulence of Helicobacter pylori. FEMS Mirobiol Lett 2007; 268:135-143.
6. Takeda K, Akira S: Toll receptors and pathogen resistance. Cell Microbiol 2003; 5:143-153.
7. Viala J, Chaput C, Boneca IG, Cardona A, Gi-rardin SE, Moran AP, Athman R, Memet S, Huerre MR, Coyle AJ, DiStefano PS, Sanso-netti PJ, Labigne A, Bertin J, Philpott DJ, Fe-rrero RL: Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol 2004; 5: 1166-1174.
8. Frye M, Bargon J, Lembcke B, Wagner TO, Gropp R: Differential expression of human alpha- and beta-defensins mRNA in gastrointestinal epithelia. Eur J Clin Investig 2000; 30: 695-701.
9. Luqmani YA, Campbell TA, Bennett C, Coombes RC, Paterson IM: Expression of lactoferrin in human stomach. Int J Cancer 1991; 49:684-687.
10. Graham DY, Opekun AR, Osata MS, El-Zimaity HM, Lee CK, Yamaoka Y, Qureshi WA, Cadoz M, Monath TP: Challenge model for Helicobacter pylori infection in human volunteers. Gut 20 04; 53: 1235-1243.
11. Terres AM, Pajares JM: An increased number of follicles containing activated CD69+ helper T cells and proliferating CD71+ B cells are found in H. pylori-infected gastric mu-cosa. Am J Gastroenterol 1998; 93: 579-583.
12. Lindholm C, Quiding-Jarbrink M, Lonroth H, Hamlet A, Svennerholm AM: Local cyto-k i n e r e s p o n s e i n Helicobacter pylori-infected subjects. Infect Immun 1998; 66:5964-5971.
13. Togawa S, Joh T, Itoh M, Katsuda N, Ito H, Matsuo K, Tajima K, Hamajima H: Interleu-kin-2 gene polymorphisms associated with increased risk of gastric atrophy from Heli-cobacter pylori infection. Helicobacter 2005; 10:172-178.
14. Wu MS, Wu CY, Chen CJ, Lin MT, Shun CT, Lin JT: Interleukin-10 genotypes associate with the risk of gastric carcinoma in Taiwanese Chinese. Int J Cancer 2003; 10 4: 617-623.
15. El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, Stanford JL, Mayne ST, Goedert J, Blot WJ, Fraumeni JF Jr, Chow WH: Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 2003; 124:1193-1201.
16. Machado JC, Figueiredo C, Canedo P, Pha-roah P, Carvalho R, Nabais S, Castro Alves C, Campos ML, Van Doorn LJ, Caldas C, Se-ruca R, Carneiro F, Sobrinho-Simoes M: A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology 2003; 125:364-371.
17. Ramsey EJ, Carey K V, Peterson WL, Jackson JJ, Murphy FK, Read NW, Taylor KB, Trier JS, Fordtran JS: Epidemic gastritis with hy-pochlorhydria. Gastroenterology 1979; 76: 14 49-1457.
18. Murphy PM: Neutrophil receptors for inter-leukin-8 and related CXC chemokines. Semin Hematol 1997; 34: 311-31 8.
19. Supajatura V, Ushio H, Wada A, Yahiro K, Okumura K, Ogawa H, Hirayama T, Ra C: Cutting edge: VacA, a vacuolating cytotoxin of Helicobacter pylori, directly activates mast cells for migration and production of proin-flammatory cytokines. J Immunol 2002; 168: 2603-2607.
20. Su B, Ceponis PJ, Lebel S, Huynh H, Sherman PM: Helicobacter pylori activates Tolllike receptor 4 expression in gastrointestinal epithelial cells. Infect Immun 2003; 71: 3496-3502.
21. Kranzer K, Eckhardt A, Aigner M, Knoll G, Deml L, Speth C, Lehn N, Rehli M, S c h ne ider-Bra c her t W: Induc t ion of mat u r a-tion and cytokine release of human dendritic cells by Helicobacter pylori. Infect Immun 2004; 72:4416-4423.
22. Umehara S, Higashi H, Ohnishi N, Asaka M, Hatakeyama M: Effects of Helicobacter pylori CagA protein on the growth and survival of B lymphocytes, the origin of MALT lymphoma. Oncogene 2003; 22: 8337-8342
23. Sundrud MS, Torres VJ, Unutmaz D, Cover TL: Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion. Proc Natl Acad Sci USA 2004; 101:7727-7732.
24. Zabaleta J, McGee DJ, Zea AH, Hernandez CP, Rodriguez PC, Sierra RA, Correa P, Ochoa AC: Helicobacter pylori arginase inhibits T cell proliferation and reduces the expression of the TCR zeta-chain (CD3£). J Immunol 2004; 173: 586-593
25. Cotugno PF, Piepoli A, Merla A, Quitada-mo M, Gentile A, Pilotto A, Annese V, An-driulli A: Abberrant DNA methylation in non-neoplastic gastric mucosa of H. pylori infected patients and effect of eradication. Am J Gastroenterol 2007; 102:1261-1371.
26. Sepulveda AR, Yao Y, Yan W, Park WI, Kim J, Gooding W, Abudayyeh S, Graham DY CpG methylation and reduced expression of O6-Methlyguanine DNA methlytransferase is associated with Helibacter pylori infection. Gastroenterology 2010; 138:836-1844.