Lewis antigens in Helicobacter pylori: Biosynthesis and phase variation

Molecular Microbiology

Volumn 36, Issue 6, 2000, Pages 1187-1196

  Wang, Ge ^a   Ge, Zhongming ^b   Rasko, David A ^a   Taylor, Diane E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; CARBOHYDRATE; EPITOPE; FUCOSYLTRANSFERASE; LIPOPOLYSACCHARIDE;

ANTIGEN EXPRESSION; BACTERIAL GENETICS; BIOSYNTHESIS; ENZYME SPECIFICITY; GENE LOCUS; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; MOLECULAR MIMICRY; PRIORITY JOURNAL; REVIEW; TRANSCRIPTION REGULATION;

ANIMALS; ANTIGENIC VARIATION; FUCOSYLTRANSFERASES; HELICOBACTER PYLORI; HUMANS; LEWIS BLOOD-GROUP SYSTEM; LIPOPOLYSACCHARIDES; OLIGOSACCHARIDES;

EID: 0033948727     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2000.01934.x     Document Type: Review

References (47)

1. Alm, R.A., Ling, L.L., Moir, D.T., King, B.L., Brown, E.D., Doig, P.C., et al. (1999) Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature 397: 176-180.
2. Appelmelk, B.J., Simoons-Smit, I.M., Negrini, R., Moran, A.P., Aspinall, G.O., Forte, J.G., et al. (1996) Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity. Infect Immun 64: 2031-2040.
3. Appelmelk, B.J., Shiberu, B., Trinks, C., Tapsi, N., Zheng, P.Y., Verboom, T., et al. (1998) Phase variation in Helicobacter pylori lipopolysaccharide. Infect Immun 66: 70-76.
4. Appelmelk, B.J., Martin, S.L., Monteiro, M.A., Clayton, C.A., McColm, A.A., Zheng, P., et al. (1999) Phase variation in Helicobacter pylori lipopolysaccharide due to changes in the lengths of poly (C) tracts in alpha3-fucosyltransferase genes. Infect Immun 67: 5361-5366.
5. Aspinall, G.O., Monteiro, M.A., Pang, H., Walsh, E.J., and Moran, A.P. (1996) Lipopolysaccharide of the Helicobacter pylori type strain NCTC 11637 (ATCC 43504): structure of the O antigen chain and core oligosaccharide regions. Biochemistry 35: 2489-2497.
6. van Belkum, A., Scherer, S., van Alphen, L., and Verbrugh, H. (1998) Short-sequence DNA repeats in prokaryotic genomes. Microbiol Mol Biol Rev 62: 275-293.
7. Berg, D.E., Hoffman, P., Appelmelk, B.J., and Kuster, J.G. (1997) The Helicobacter pylori genome sequence: genetic factors for long life in the gastric mucosa. Trends Microbiol 12: 468-474.
8. Boren, T., Falk, P., Roth, K.A., Larson, G., and Normark, S. (1993) Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 262: 1892-1895.
9. Chan, N.W.C., Stangier, K., Sherburne, R., Zhang, Y., Dovichi, N.J., and Palcic, M.M. (1995) The biosynthesis of Lewis X in Helicobacter pylori. Glycobiology 5: 683-688.
10. Claeys, D., Faller, G., Appelmelk, B.J., Negrini, R., and Kirchner, T. (1998) The gastric H+, K+-ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body mucosa atrophy. Gastroenterology 115: 340-347.
11. Faller, G., Steininger, H., Appelmelk, B., and Kirchner, T. (1998) Evidence of novel pathogenic pathways for the formation of antigastric autoantibodies in Helicobacter pylori gastritis. J Clin Pathol 51: 244-245.
12. Ge, Z., Chan, N.W.C., Palcic, M.M., and Taylor, D.E. (1997) Cloning and heterologous expression of an α1,3 fucosyltransferase gene from the gastric pathogen Helicobacter pylori. J Biol Chem 272: 21357-21363.
13. Ge, Z., Chien, C.-C., Zhang, F., and Fox, J.G. (1999) The Helicobacter pylori α1,3-fucosyltransferase gene: sequence diversity and mispairing slippage. Gastroenterology 116: A169.
14. Gibson, J.R., Chart, H., and Owen, R.J. (1998) Intra-strain variation in expression of lipopolysaccharide by Helicobacter pylori. Lett Appl Microbiol 26: 399-403.
15. Hakomori, S. (1992) Le (X) and related structures as adhesin molecules. Histochem J 24: 771-776.
16. Heneghan, M.A., Moran, A.P., Feeley, K.M., Egan, E.L., Goulding, J., Connolly, C.E., and McCarthy, C.F. (1998) Effect of host Lewis and ABO blood group antigen expression on Helicobacter pylori colonisation density and the consequent inflammatory response. FEMS Immunol Med Microbiol 20: 257-266.
17. Heneghan, M.A., McCarthy, C.F., and Moran, A.P. (2000) Relationship of blood group determinants on Helicobacter pylori lipopolysaccharide with host lewis phenotype and inflammatory response. Infect Immun 68: 937-941.
18. Henry, S., Oriol, R., and Samuesson, B. (1995) Lewis histo-blood group system and associated secretory phenotypes. Vox Sang 69: 166-182.
19. Kleene, R., and Berger, E.G. (1993) The molecular and cell biology of glycosyltransferases. Biochim Biophys Acta 1154: 283-325.
20. Knirel, Y.A., Kocharova, N.A., Hynes, S.O., Widmalm, G., Andersen, L.P., Jansson, P.E., and Moran, A.P. (1999) Structural studies on lipopolysaccharides of serologically non-typable strains of Helicobacter pylori, AF1 and 007, expressing Lewis antigenic determinants. Eur J Biochem 266: 123-131.
21. Kuipers, E.J. (1997) Helicobacter pylori and the risk and management of associated diseases: gastritis, ulcer disease, atrophic gastritis and gastric cancer. Aliment Pharmacol Ther 11 (Suppl. 1): 71-88.
22. Logan, S.M., Conlan, J.W., Monteiro, M.A., Wakarchuk, W.W., and Altman, E. (2000) Functional genomics of Helicobacter pylori: identification of a beta-1,4 galactosyltransferase and generation of mutants with altered lipopolysaccharide. Mol Microbiol 35: 1156-1167.
23. Marshall, D.G., Hynes, S.O., Coleman, D.C., O'Morain, C.A., Smyth, C.J., and Moran, A.P. (1999) Lack of a relationship between Lewis antigen expression and cagA, Cag, vacA, and VacA status of Irish Helicobacter pylori isolates. FEMS Immunol Med Microbiol 24: 79-90.
24. Martin, S.L., Edbrooke, M.R., Hodgman, T.C., van den Eijnden, D.H., and Bird, M.I. (1997) Lewis X biosynthesis in Helicobacter pylori. Molecular cloning of an α (1,3) fucosyltransferase gene. J Biol Chem 272: 21349-21356.
25. McGowan, C.C., Necheva, A., Thompson, S.A., Cover, T.L., and Blaser, M.J. (1998) Acid-induced expression of an LPS-associated gene in Helicobacter pylori. Mol Microbiol 30: 19-31.
26. Monteiro, M.A., Chan, K.H.N., Rasko, D.A., Taylor, D.E., Zheng, P.Y., Appelmelk, B.J., et al. (1998) Simultaneous expression of type 1 and type 2 Lewis blood group by Helicobacter pylori lipopolysaccharides. J Biol Chem 273: 11533-11543.
27. Monteiro, M.A., Appelmelk, B.J., Rasko, D.A., Moran, A.P., Hynes, S.O., Maclean, L.L., et al. (2000) Lipopolysaccharide structures of Helicobacter pylori genomic strains 26695 and J99, mouse model H. pylori Sydney strain, H. pylori P466 carrying sialyl Lewis X, and H. pylori UA915 expressing Lewis B: Classification of H. pylori lipopolysaccharides into Glycotype families. Eur J Biochem 267: 305-320.
28. Moran, A.P. (1995) Cell surface characteristics of Helicobacter pylori. FEMS Immnunol Med Microbiol 10: 271-280.
29. Moran, A.P., Prendergast, M.M., and Appelmelk, B.J. (1996) Molecular mimicry of host structures by bacterial lipopolysaccharides and its contribution to disease. FEMS Immun Med Microbiol 16: 105-115.
30. Negrini, R., Savio, A., Poiesi, C., Appelmelk, B.J., Buffoli, F., Paterlini, A., et al. (1996) Antigenic mimicry between Helicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis. Gastroenterology 111: 655-665.
31. Oriol, R., Mollicone, R., CailLeau, A., Balanzino, L., and Breton, C. (1999) Divergent evolution of fucosyltransferase genes from vertebrates, invertebrates, and bacteria. Glycobiology 9: 323-334.
32. Rasko, D.A., Wilson, T.J.M., Zopf, D., and Taylor, D.E. (2000a) Lewis antigen expression and stability in Helicobacter pylori isolated from serial gastric biopsies. J Infect Dis 181: 1089-1095.
33. Rasko, D.A., Wang, G., Palcic, M.M., and Taylor, D.E. (2000b) Cloning and characterization of the α1,3/4 fucosyltransferase of Helicobacter pylori. J Biol Chem 275: 4988-4994.
34. Sherburne, R., and Taylor, D.E. (1995) Helicobacter pylori expresses a complex surface carbohydrate, Lewis X. Infect Immun 63: 4564-4568.
35. Shiberu, B., and Goldberg, J.B. (1999) Molecular cloning and characterization of Helicobacter pylori 26695 rfaJ genes HP1416 and HP0159. In Abstracts 10th International Workshop CHRO, Mobley, H.L.T., Nachamkin, I., and McGee, D. (eds). pp. 130(HG8).
36. Simoons-Smit, I.M., Appelmelk, B.J., Verboom, T., Negrini, R., Penner, J.L., Aspinall, G.O., et al. (1996) Typing of Helicobacter pylori with monoclonal antibodies against Lewis antigens in lipopolysaccharide. J Clin Microbiol 34: 2196-2200.
37. Taylor, D.E., Rasko, D.A., Sherburne, R., Ho, C., and Jewell, L.D. (1998) Lack of correlation between Lewis antigen expression by Helicobacter pylori and gastric epithelial cells in infected patients. Gastroenterology 115: 1113-1122.
38. Tomb, J.-F., White, O., Kerlavage, A.R., Clayton, R.A., Sutton, G.G., Fleischmann, R.D., et al. (1997) The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388: 539-547.
39. Valkonen, K.H., Wadstrom, T., and Moran, A.P. (1997) Identification of the N-acetylneuraminyllactose specific laminin binding protein of Helicobacter pylori. Infect Immun 65: 916-923.
40. Wang, G., Rasko, D.A., Sherburne, R., and Taylor, D.E. (1999a) Molecular genetic basis for the variable expression of Lewis Y antigen in Helicobacter pylori: analysis of the α (1,2) fucosyltransferase gene. Mol Microbiol 31: 1265-1274.
41. Wang, G., Boulton, P.G., Chan, N.W.C., Palcic, M.M., and Taylor, D.E. (1999b) Novel Helicobacter pylori α1,2 fucosyltransferase, a key enzyme in the synthesis of Lewis antigens. Microbiology 145: 3245-3253.
42. Wirth, H.-P., Yang, M., Karita, M., and Blaser, M.J. (1996) Expression of the human cell surface glycoconjugates Lewis X and Lewis Y by Helicobacter pylori isolates is related to cagA status. Infect Immun 64: 4598-4605.
43. Wirth, H.-P., Yang, M., Peek, R.M., Tham, K.T., and Blaser, M.J. (1997) Helicobacter pylori Lewis expression is related to the host Lewis phenotype. Gastroenterology 113: 1091-1098.
44. Wirth, H.-P., Yang, M., Dubois, A., Berg, D.E., and Blaser, M.J. (1998) Selection of Helicobacter pylori Lewis expression is dependent on host Lewis phenotype in Rhesus monkeys. Gastroenterology 114 (Suppl. 4): A332.
45. Wirth, H.-P., Yang, M., Peek, R.M., Hook-Nikanne, J., and Blaser, M.J. (1999) Phenotypic diversity in Lewis expression of Helicobacter pylori isolates from the same host. J Lab Clin Med 133: 488-500.
46. Yokota, S.I., Amano, K.I., Hayashi, S., Kubota. T., Fujii, N., and Yokochi, T. (1998) Human antibody response to Helicobacter pylori lipopolysaccharide: presence of an immunodominant epitope in the polysaccharide chain of lipopolysaccharide. Infect Immun 66: 3006-3011.
47. Yokota, S.I., Amano, K.I., Shibata, Y., Nakajima, M., Suzuki, M., Hayashi, S., et al. (2000) Two distinct antigenic types of the polysaccharide chains of Helicobacter pylori lipopolysaccharides characterized by reactivity with sera from humans with natural infection. Infect Immun 68: 151-159.