Phosphorylated Smad2 in Advanced Stage Gastric Carcinoma

BMC Cancer

Volumn 10, Issue , 2010, Pages

  Shinto, Osamu ^a   Yashiro, Masakazu ^a   Toyokawa, Takahiro ^a   Nishii, Takafumi ^a   Kaizaki, Ryoji ^a   Matsuzaki, Taro ^a   Noda, Satoru ^a   Kubo, Naoshi ^a   Tanaka, Hiroaki ^a   Doi, Yosuke ^a   Ohira, Masaichi ^a   Muguruma, Kazuya ^a   Sawada, Tetsuji ^a   Hirakawa, Kosei ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

SMAD2 PROTEIN; PARAFFIN; SMAD2 PROTEIN, HUMAN;

ADVANCED CANCER; ARTICLE; CANCER INVASION; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PERITONEUM METASTASIS; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STOMACH ADENOCARCINOMA; ADENOCARCINOMA; CHEMISTRY; CHI SQUARE DISTRIBUTION; IMMUNOHISTOCHEMISTRY; JAPAN; KAPLAN MEIER METHOD; METASTASIS; MORTALITY; PATHOLOGY; PERITONEUM TUMOR; PHOSPHORYLATION; PROPORTIONAL HAZARDS MODEL; RISK ASSESSMENT; RISK FACTOR; STOMACH TUMOR; TIME;

ADENOCARCINOMA; CHI-SQUARE DISTRIBUTION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; JAPAN; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; MALE; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PARAFFIN EMBEDDING; PERITONEAL NEOPLASMS; PHOSPHORYLATION; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; RISK FACTORS; SMAD2 PROTEIN; STOMACH NEOPLASMS; TIME FACTORS;

EID: 78649319198     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-652     Document Type: Article

References (29)

1. Miyazono K, Suzuki H, Imamura T. Regulation of TGF-beta signaling and its roles in progression of tumors. Cancer Sci 2003, 94(3):230-234. 10.1111/j.1349-7006.2003.tb01425.x, 12824914.
2. Massague J. TGFbeta in Cancer. Cell 2008, 134(2):215-230. 10.1016/j.cell.2008.07.001, 18662538.
3. Massague J, Seoane J, Wotton D. Smad transcription factors. Genes Dev 2005, 19(23):2783-2810. 10.1101/gad.1350705, 16322555.
4. Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003, 425(6958):577-584. 10.1038/nature02006, 14534577.
5. Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 2001, 29(2):117-129. 10.1038/ng1001-117, 11586292.
6. Moustakas A, Heldin CH. Non-Smad TGF-beta signals. J Cell Sci 2005, 118(Pt 16):3573-3584. 10.1242/jcs.02554, 16105881.
7. Bruna A, Darken RS, Rojo F, Ocana A, Penuelas S, Arias A, Paris R, Tortosa A, Mora J, Baselga J, et al. High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 2007, 11(2):147-160. 10.1016/j.ccr.2006.11.023, 17292826.
8. Fukuchi M, Nakajima M, Miyazaki T, Masuda N, Osawa H, Manda R, Tsukada K, Kato H, Kuwano H. Lack of activated Smad2 in transforming growth factor-beta signaling is an unfavorable prognostic factor in patients with esophageal squamous cell carcinoma. J Surg Oncol 2006, 94(1):51-56. 10.1002/jso.20565, 16788944.
9. Xie W, Mertens JC, Reiss DJ, Rimm DL, Camp RL, Haffty BG, Reiss M. Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study. Cancer Res 2002, 62(2):497-505.
10. Xie W, Rimm DL, Lin Y, Shih WJ, Reiss M. Loss of Smad signaling in human colorectal cancer is associated with advanced disease and poor prognosis. Cancer J 2003, 9(4):302-312. 10.1097/00130404-200307000-00013, 12967141.
11. Saito H, Tsujitani S, Oka S, Kondo A, Ikeguchi M, Maeta M, Kaibara N. An elevated serum level of transforming growth factor-beta 1 (TGF-beta 1) significantly correlated with lymph node metastasis and poor prognosis in patients with gastric carcinoma. Anticancer Res 2000, 20(6B):4489-4493.
12. Lin Y, Kikuchi S, Obata Y, Yagyu K. Serum levels of transforming growth factor beta1 are significantly correlated with venous invasion in patients with gastric cancer. J Gastroenterol Hepatol 2006, 21(2):432-437. 10.1111/j.1440-1746.2005.03939.x, 16509870.
13. Japanese Gastric Cancer A Japanese Classification of Gastric Carcinoma - 2nd English Edition. Gastric Cancer 1998, 1(1):10-24. Japanese Gastric Cancer A.
14. Shinto O, Yashiro M, Kawajiri H, Shimizu K, Shimizu T, Miwa A, Hirakawa K. Inhibitory effect of a TGFbeta receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells. Br J Cancer 102(5):844-851. 10.1038/sj.bjc.6605561, 20145621.
15. Allred DC, Harvey JM, Berardo M, Clark GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol 1998, 11(2):155-168.
16. Sobin LH, Fleming ID. TNM Classification of Malignant Tumors, fifth edition (1997). Union Internationale Contre le Cancer and the American Joint Committee on Cancer. Cancer 1997, 80(9):1803-1804. 10.1002/(SICI)1097-0142(19971101)80:9<1803::AID-CNCR16>3.0.CO;2-9, 9351551.
17. Lauren P. The Two Histological Main Types of Gastric Carcinoma: Diffuse and So-Called Intestinal-Type Carcinoma. an Attempt at a Histo-Clinical Classification. Acta Pathol Microbiol Scand 1965, 64:31-49.
18. Nakazawa K, Yashiro M, Hirakawa K. Keratinocyte growth factor produced by gastric fibroblasts specifically stimulates proliferation of cancer cells from scirrhous gastric carcinoma. Cancer Res 2003, 63(24):8848-8852.
19. Fujihara T, Yashiro M, Inoue T, Sawada T, Kato Y, Ohira M, Nishiguchi Y, Ishikawa T, Sowa M, Chung KH. Decrease in ICAM-1 expression on gastric cancer cells is correlated with lymph node metastasis. Gastric Cancer 1999, 2(4):221-225. 10.1007/s101200050067, 11957102.
20. Hippo Y, Yashiro M, Ishii M, Taniguchi H, Tsutsumi S, Hirakawa K, Kodama T, Aburatani H. Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes. Cancer Res 2001, 61(3):889-895.
21. Yashiro M, Chung YS, Kubo T, Hato F, Sowa M. Differential responses of scirrhous and well-differentiated gastric cancer cells to orthotopic fibroblasts. Br J Cancer 1996, 74(7):1096-1103. 2077126, 8855981.
22. Tendo M, Yashiro M, Nakazawa K, Yamada N, Hirakawa K. Inhibitory effect of a selective cyclooxygenase inhibitor on the invasion-stimulating activity of orthotopic fibroblasts for scirrhous gastric cancer cells. Cancer Sci 2005, 96(7):451-455. 10.1111/j.1349-7006.2005.00066.x, 16053517.
23. Takemura S, Yashiro M, Sunami T, Tendo M, Hirakawa K. Novel models for human scirrhous gastric carcinoma in vivo. Cancer Sci 2004, 95(11):893-900. 10.1111/j.1349-7006.2004.tb02199.x, 15546507.
24. Kinugasa S, Abe S, Tachibana M, Hishikawa Y, Yoshimura H, Monden N, Dhar DK, Nagasue N, Nagaoka S. Overexpression of transforming growth factor-beta1 in scirrhous carcinoma of the stomach correlates with decreased survival. Oncology 1998, 55(6):582-587. 10.1159/000011916, 9778627.
25. Mahara K, Kato J, Terui T, Takimoto R, Horimoto M, Murakami T, Mogi Y, Watanabe N, Kohgo Y, Niitsu Y. Transforming growth factor beta 1 secreted from scirrhous gastric cancer cells is associated with excess collagen deposition in the tissue. British journal of cancer 1994, 69(4):777-783. 1968800, 8142266.
26. Yoshida K, Yokozaki H, Niimoto M, Ito H, Ito M, Tahara E. Expression of TGF-beta and procollagen type I and type III in human gastric carcinomas. International journal of cancer 1989, 44(3):394-398.
27. Yang L, Moses HL. Transforming growth factor beta: tumor suppressor or promoter? Are host immune cells the answer?. Cancer research 2008, 68(22):9107-9111. 10.1158/0008-5472.CAN-08-2556, 2741321, 19010878.
28. Kawajiri H, Yashiro M, Shinto O, Nakamura K, Tendo M, Takemura S, Node M, Hamashima Y, Kajimoto T, Sawada T, et al. A novel transforming growth factor beta receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma. Clin Cancer Res 2008, 14(9):2850-2860. 10.1158/1078-0432.CCR-07-1634, 18451253.
29. Kano MR, Bae Y, Iwata C, Morishita Y, Yashiro M, Oka M, Fujii T, Komuro A, Kiyono K, Kaminishi M, et al. Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling. Proc Natl Acad Sci USA 2007, 104(9):3460-3465. 10.1073/pnas.0611660104, 1800736, 17307870.