Association study of gene polymorphisms involved in vascular alterations in elderly hypertensives with subjective memory complaints

Dementia and Geriatric Cognitive Disorders

Volumn 30, Issue 5, 2010, Pages 440-448

  Watfa, Ghassan ^a,b,c   Marteau, Jean Brice ^c   Rossignol, Patrick ^a,b,c   Kearney Schwartz, Anna ^a   Fay, Renaud ^a   Bracard, Serge ^a,c,d   Felblinger, Jacques ^c,d   Boivin, Jean Marc ^a,c   Lacolley, Patrick ^b,c   Visvikis Siest, Sophie ^a,c   Benetos, Athanase ^a,b,c   Zannad, Faïez ^a,b,c  

^a UNIVERSITY HOSPITAL OF NANCY   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE LORRAINE   (France)

^d CHU NANCY BRABOIS   (France)

Author keywords

Aging; Gene polymorphism; Genetic association; Hypertension; Leukoaraiosis; Memory impairment

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN;

ADULT; AGE; AGED; ARTICLE; BLOOD PRESSURE REGULATION; BODY MASS; CHOLESTEROL BLOOD LEVEL; COGNITIVE DEFECT; CROSS-SECTIONAL STUDY; DISEASE MARKER; DISEASE SEVERITY; FEMALE; GENDER; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HYPERTENSION; INFLAMMATION; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; MEMORY; MEMORY DISORDER; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; SUBJECTIVE MEMORY COMPLAINT; THROMBOSIS; VASCULAR DISEASE; VERBALIZATION; VISION; WHITE MATTER HYPERINTENSITY;

AGED; AGED, 80 AND OVER; APOLIPOPROTEINS E; BLOOD PRESSURE; BLOOD VESSELS; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; DATA INTERPRETATION, STATISTICAL; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; GENOTYPE; HOMOCYSTEINE; HUMANS; HYPERTENSION; INFLAMMATION; LIPID METABOLISM; MAGNETIC RESONANCE IMAGING; MALE; MEMORY DISORDERS; MIDDLE AGED; MULTIGENE FAMILY; POLYMORPHISM, GENETIC; THROMBOSIS;

EID: 78649316069     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000321120     Document Type: Article

References (40)

1. Grober E, Lipton RB, Hall C, Crystal H: Memory impairment on free and cued selective reminding predicts dementia. Neurology 2000; 54: 827-832.
2. Borenstein AR, Mortimer JA, Ding D, Schellenberg GD, Decarli C, Zhao Q, Copenhaver C, Guo Q, Chu S, Galasko D, Salmon DP, Dai Q, Wu Y, Petersen R, Hong Z: Effects of apolipoprotein E-ε 4 and -ε 2 in amnestic mild cognitive impairment and dementia in Shanghai: SCOBHI-P. Am J Alzheimers Dis Other Demen 2010; 25: 233-238.
3. Boyle PA, Buchman AS, Wilson RS, Kelly JF, Bennett DA: The aPOEε 4 allele is associated with incident mild cognitive impairment among community-dwelling older persons. Neuroepidemiology 2010; 34: 43-49.
4. Elias MF, Wolf PA, D'Agostino RB, Cobb J, White LR: Untreated blood pressure level is inversely related to cognitive functioning: the Framingham Study. Am J Epidemiol 1993; 138: 353-364.
5. Launer LJ, Ross GW, Petrovitch H, Masaki K, Foley D, White LR, Havlik RJ: Midlife blood pressure and dementia: the Honolulu-Asia Aging Study. Neurobiol Aging 2000; 21: 49-55.
6. Gorgone G, Ursini F, Altamura C, Bressi F, Tombini M, Curcio G, Chiovenda P, Squitti R, Silvestrini M, Ientile R, Pisani F, Rossini PM, Vernieri F: Hyperhomocysteinemia, intima- media thickness and C677T MTHFR gene polymorphism: a correlation study in patients with cognitive impairment. Atherosclerosis 2009; 206: 309-313.
7. Kuo HK, Chen CY, Liu HM, Yen CJ, Chang KJ, Chang CC, Yu YH, Lin LY, Hwang JJ: Metabolic risks, white matter hyperintensities, and arterial stiffness in high-functioning healthy adults. Int J Cardiol 2010; 143: 184-191.
8. Mosley TH Jr, Knopman DS, Catellier DJ, Bryan N, Hutchinson RG, Grothues CA, Folsom AR, Cooper LS, Burke GL, Liao D, Szklo M: Cerebral MRI findings and cognitive functioning: the Atherosclerosis Risk in Communities Study. Neurology 2005; 64: 2056-2062.
9. Sierra C, de la Sierra A, Salamero M, Sobrino J, Gomez-Angelats E, Coca A: Silent cerebral white matter lesions and cognitive function in middle-aged essential hypertensive patients. Am J Hypertens 2004; 17: 529-534.
10. Kearney-Schwartz A, Rossignol P, Bracard S, Felblinger J, Fay R, Boivin JM, Lecompte T, Lacolley P, Benetos A, Zannad F: Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints. Stroke 2009; 40: 1229-1236.
11. Marteau JB, Sass C, Pfister M, Lambert D, Noyer-Weidner M, Visvikis S: The Leu- 554Phe polymorphism in the E-selectin gene is associated with blood pressure in overweight people. J Hypertens 2004; 22: 305-311.
12. Sass C, Cheng S, Siest G, Visvikis S: Genetic influences on blood pressure within the Stanislas cohort. J Hypertens 2004; 22: 297-304.
13. Awad IA, Spetzler RF, Hodak JA, Awad CA, Carey R: Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. 1. Correlation with age and cerebrovascular risk factors. Stroke 1986; 17: 1084-1089.
14. Hassan A, Lansbury A, Catto AJ, Guthrie A, Spencer J, Craven C, Grant PJ, Bamford JM: Angiotensin-converting enzyme insertion/ deletion genotype is associated with leukoaraiosis in lacunar syndromes. J Neurol Neurosurg Psychiatry 2002; 72: 343-346.
15. Cerhan JR, Folsom AR, Mortimer JA, Shahar E, Knopman DS, McGovern PG, Hays MA, Crum LD, Heiss G: Correlates of cognitive function in middle-aged adults. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Gerontology 1998; 44: 95-105.
16. Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak- Vance MA, Risch N, van Duijn CM: Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis. APOE and Alzheimer Disease Meta-Analysis Consortium. JAMA 1997; 278: 1349-1356.
17. Caselli RJ, Dueck AC, Osborne D, Sabbagh MN, Connor DJ, Ahern GL, Baxter LC, Rapcsak SZ, Shi J, Woodruff BK, Locke DE, Snyder CH, Alexander GE, Rademakers R, Reiman EM: Longitudinal modeling of agerelated memory decline and the APOE 4 effect. N Engl J Med 2009; 361: 255-263.
18. Coraci IS, Husemann J, Berman JW, Hulette C, Dufour JH, Campanella GK, Luster AD, Silverstein SC, El-Khoury JB: CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to β - amyloid fibrils. Am J Pathol 2002; 160: 101-112.
19. Krabbe KS, Mortensen EL, Avlund K, Pilegaard H, Christiansen L, Pedersen AN, Schroll M, Jørgensen T, Pedersen BK, Bruunsgaard H: Genetic priming of a proinflammatory profile predicts low IQ in octogenarians. Neurobiol Aging 2009; 30: 769-781.
20. Watanabe T, Koba S, Kawamura M, Itokawa M, Idei T, Nakagawa Y, Iguchi T, Katagiri T: Small dense low-density lipoprotein and carotid atherosclerosis in relation to vascular dementia. Metabolism 2004; 53: 476-482.
21. Derouesné C: Dementia: diagnostic problems (in French). Therapie 1993; 48: 189-193.
22. Watfa G, Rossignol P, Kearney-Schwartz A, Fay R, Bracard S, Felblinger J, Boivin JM, Lacolley P, Zannad F, Benetos A: Use of calcium channel blockers is associated with better cognitive performance in older hypertensive patients with subjective memory complaints. J Hypertens 2010, E-pub ahead of print.
23. Folstein MF, Folstein SE, McHugh PR: 'Mini-Mental State': a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
24. Verdelho A, Henon H, Lebert F, Pasquier F, Leys D: Depressive symptoms after stroke and relationship with dementia: a three-year follow-up study. Neurology 2004; 62: 905-911.
25. O'Brien E, Asmar R, Beilin L, Imai Y, Mancia G, Mengden T, Myers M, Padfield P, Palatini P, Parati G, Pickering T, Redon J, Staessen J, Stergiou G, Verdecchia P: Practice guidelines of the European Society of Hypertension for clinic, ambulatory and self blood pressure measurement. J Hypertens 2005; 23: 697-701.
26. Grober E, Buschke H, Crystal H, Bang S, Dresner R: Screening for dementia by memory testing. Neurology 1988; 38: 900-903.
27. Spreen O, Benton AL: Simulation of mental deficiency on a visual memory test. Am J Ment Defic 1963; 67: 909-913.
28. Peigneux P, van der Linden M, Andres-Benito P, Sadzot B, Franck G, Salmon E: A neuropsychological and functional brain imaging study of visuo-imitative apraxia (in French). Rev Neurol (Paris) 2000; 156: 459-472.
29. Spreen O: Prognosis of learning disability. J Consult Clin Psychol 1988; 56: 836-842.
30. Cheng S, Grow MA, Pallaud C, Klitz W, Erlich HA, Visvikis S, Chen JJ, Pullinger CR, Malloy MJ, Siest G, Kane JP: A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res 1999; 9: 936-949.
31. Kerber KA, Whitman GT, Brown DL, Baloh RW: Increased risk of death in communitydwelling older people with white matter hyperintensities on MRI. J Neurol Sci 2006; 250: 33-38.
32. Hachinski VC, Potter P, Merskey H: Leukoaraiosis: an ancient term for a new problem. Can J Neurol Sci 1986; 13: 533-534.
33. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA: MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol 1987; 149: 351-356.
34. Cusi D, Barlassina C, Azzani T, Casari G, Citterio L, Devoto M, Glorioso N, Lanzani C, Manunta P, Righetti M, Rivera R, Stella P, Troffa C, Zagato L, Bianchi G: Polymorphisms of α -adducin and salt sensitivity in patients with essential hypertension. Lancet 1997; 349: 1353-1357.
35. Bray MS, Li L, Turner ST, Kardia SL, Boerwinkle E: Association and linkage analysis of the α -adducin gene and blood pressure. Am J Hypertens 2000; 13: 699-703.
36. Shin MH, Chung EK, Kim HN, Park KS, Nam HS, Kweon SS, Choi JS: -Adducin Gly- 460Trp polymorphism and essential hypertension in Korea. J Korean Med Sci 2004; 19: 812-814.
37. Larson N, Hutchinson R, Boerwinkle E: Lack of association of 3 functional gene variants with hypertension in African Americans. Hypertension 2000; 35: 1297-1300.
38. Bartrés-Faz D, Junqué C, López-Alomar A, Valveny N, Moral P, Casamayor R, Salido A, Bel C, Clemente IC: Neuropsychological and genetic differences between age-associated memory impairment and mild cognitive impairment entities. J Am Geriatr Soc 2001; 49: 985-990.
39. Soininen HS, Riekkinen PJ Sr: Apolipoprotein E, memory and Alzheimer's disease. Trends Neurosci 1996; 19: 224-228.
40. Persson J, Lind J, Larsson A, Ingvar M, Cruts M, van Broeckhoven C, Adolfsson R, Nilsson LG, Nyberg L: Altered brain white matter integrity in healthy carriers of the A POE 4 allele: a risk for AD? Neurology 2006; 66: 1029-1033.