Are rats the appropriate experimental model to understand age-related renal drug metabolism and toxicity?

Expert Opinion on Drug Metabolism and Toxicology

Volumn 6, Issue 12, 2010, Pages 1451-1459

  Trevisan, Andrea ^a   Nicolli, Annamaria ^a   Chiara, Federica ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Adverse drug reaction; Ageing; Drugs; Hydrocarbons; Metals; Rats

Indexed keywords

AMINOGLYCOSIDE; CADMIUM; CEFALORIDINE; CHROMIC ACID; CISPLATIN; GENTAMICIN; HEXACHLOROBUTADIENE; PARACETAMOL; SALICYLIC ACID; THALLIUM; TOBRAMYCIN; VANADIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; CALORIC RESTRICTION; DRUG DISPOSITION; DRUG METABOLISM; DRUG TRANSFORMATION; EMBRYO DEVELOPMENT; EVENING DOSAGE; HUMAN; KIDNEY DISEASE; MORNING DOSAGE; NEPHROTOXICITY; NONHUMAN; PROTEIN INTAKE; RAT; REVIEW; SINGLE DRUG DOSE;

AGE FACTORS; AGING; ANIMALS; HUMANS; KIDNEY; KIDNEY DISEASES; MODELS, ANIMAL; RATS; RODENTIA; SPECIES SPECIFICITY; XENOBIOTICS;

ANIMALIA; RATTUS; RODENTIA;

EID: 78649310852     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425255.2010.531701     Document Type: Review

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