Oxidative stress, inflammation, and DNA damage in rats after intratracheal instillation or oral exposure to ambient air and wood smoke particulate matter

Toxicological Sciences

Volumn 118, Issue 2, 2010, Pages 574-585

  Danielsen, Pernille Høgh ^a   Loft, Steffen ^a   Jacobsen, Nicklas Raun ^b   Jensen, Keld Alstrup ^b   Autrup, Herman ^c   Ravanat, Jean Luc ^d   Wallin, Håkan ^a,b   Møller, Peter ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

^d UNIV GRENOBLE ALPES   (France)

Author keywords

DNA damage; Etheno adducts; Inflammation; Oral exposure; Oxidative stress; Wood smoke particles

Indexed keywords

1 N 2 ETHENO 2' DEOXYADENOSINE; 1,N 6 ETHENO 2' DEOXYADENOSINE; 8 HYDROXYDEOXYGUANOSINE; CYTOKINE; DEOXYADENOSINE; DNA GLYCOSYLTRANSFERASE; HEME OXYGENASE 1; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; OXOGUANINE DNA GLYCOSYLASE 1; UNCLASSIFIED DRUG;

AMBIENT AIR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; COMBUSTION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION; GENOTOXICITY; INFLAMMATION; LIVER; LUNG ALVEOLUS CELL; LUNG LAVAGE; LUNG PARENCHYMA; MALE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PARTICULATE MATTER; RAT; SMOKE; TOXIC INHALATION; WOOD;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; CHEMOKINE CCL2; CHEMOKINE CXCL2; CYTOKINES; DNA ADDUCTS; DNA DAMAGE; DNA GLYCOSYLASES; GENE EXPRESSION; HEME OXYGENASE-1; INTUBATION, INTRATRACHEAL; MALE; MEMBRANE PROTEINS; OXIDATIVE STRESS; PARTICULATE MATTER; PNEUMONIA; RATS; RATS, INBRED F344; SMOKE; WOOD;

RATTUS;

EID: 78549272716     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq290     Document Type: Article

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