Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/Raf-1/MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes

Biochemical and Biophysical Research Communications

Volumn 402, Issue 3, 2010, Pages 554-559

  Ogasawara, Junetsu ^a   Kitadate, Kentaro ^b   Nishioka, Hiroshi ^b   Fujii, Hajime ^b   Sakurai, Takuya ^a   Kizaki, Takako ^a   Izawa, Tetsuya ^c   Ishida, Hitoshi ^a   Tanno, Masataka ^d   Ohno, Hideki ^a  

^a KYORIN UNIVERSITY   (Japan)

^b Amino Up Chemical Co Ltd ^*  (Japan)

^c DOSHISHA UNIVERSITY   (Japan)

^d NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

IL 6; MEK1 2; Oligonol; Primary adipocytes; Raf 1; Ras

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 (3,5 DIBROMO 4 HYDROXYBENZYLIDENE) 1,3 DIHYDRO 5 IODO 2 INDOLONE; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; OLIGONOL; POLYPHENOL DERIVATIVE; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; LIPOLYSIS; LYCHEE; MALE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ADIPOCYTES; ANIMALS; ANTI-OBESITY AGENTS; CATECHIN; FLAVONOIDS; FRUIT; INTERLEUKIN-6; LITCHI; MALE; MAP KINASE KINASE 1; MAP KINASE KINASE 2; OBESITY; PHENOLS; PROTO-ONCOGENE PROTEINS C-RAF; RAS PROTEINS; RATS; RATS, WISTAR;

LITCHI CHINENSIS; RATTUS;

EID: 78549250667     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.10.082     Document Type: Article

References (31)

1. McCubrey J.A., Steelman L.S., Chappell W.H., et al. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim. Biophys. Acta 2007, 1773:1263-1284.
2. Steelman L.S., Pohnert S.C., Shelton J.G., et al. JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 2004, 18:189-218.
3. Wang Y., Zhao L., Smas C., et al. Pref-1 interacts with fibronectin to inhibit adipocyte differentiation. Mol. Cell. Biol. 2010, 30:3480-3492.
4. Rydén M., Arvidsson E., Blomqvist L., et al. Targets for TNF-alpha-induced lipolysis in human adipocytes. Biochem. Biophys. Res. Commun. 2004, 318:168-175.
5. Yang Y., Ju D., Zhang M., et al. Interleukin-6 stimulates lipolysis in porcine adipocytes. Endocrine 2008, 33:261-269.
6. Ahn J., Lee H., Kim S., et al. Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/beta-catenin signaling. Am. J. Physiol. Cell Physiol. 2010, 298:C1510-C1516.
7. Ogasawara J., Kitadate K., Nishioka H., et al. Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway. Phytother. Res. 2009, 23:1626-1633.
8. Fujii H., Nishioka H., Wakame K., et al. Acute, subchronic and genotoxicity studies conducted with Oligonol, an oligomerized polyphenol formulated from lychee and green tea extracts. Food Chem. Toxicol. 2008, 46:3553-3562.
9. Jo E.H., Lee S.J., Ahn N.A., et al. Induction of apoptosis in MCF-7 and MDA-MB-231 breast cancer cells by Oligonol is mediated by Bcl-2 family regulation and MEK/ERK signaling. Eur. J. Cancer Prev. 2007, 16:342-347.
10. Sakurai T., Nishioka H., Fujii H., et al. Antioxidative effects of a new lychee fruit-derived polyphenol mixture, oligonol, converted into a low-molecular form in adipocytes. Biosci. Biotechnol. Biochem. 2008, 72:463-476.
11. Miyaoka Y., Tanaka M., Naiki T., et al. Oncostatin M inhibits adipogenesis through the RAS/ERK and STAT5 signaling pathways. J. Biol. Chem. 2006, 281:37913-37920.
12. Mohamed-Ali V., Flower L., Sethi J., et al. Beta-adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies. J. Clin. Endocrinol. Metab. 2001, 86:5864-5869.
13. Flower L., Gray R., Pinkney J., et al. Stimulation of interleukin-6 release by interleukin-1beta from isolated human adipocytes. Cytokine 2003, 21:32-37.
14. Lagathu C., Bastard J.P., Auclair M., et al. Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochem. Biophys. Res. Commun. 2003, 311:372-379.
15. Rodbell M. Metabolism of isolated fat cells. Effect of hormones on glucose metabolism and lipolysis. J. Biol. Chem. 1964, 239:375-380.
16. Souza S.C., Palmer H.J., Kang Y.H., et al. TNF-alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes. J. Cell. Biochem. 2003, 89:1077-1086.
17. Ara T., Declerck Y.A. Interleukin-6 in bone metastasis and cancer progression. Eur. J. Cancer 2010, 46:1223-1231.
18. Khan N., Afaq F., Saleem M., et al. Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. Cancer Res. 2006, 66:2500-2505.
19. Balasubramanian S., Efimova T., Eckert R.L. Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes. J. Biol. Chem. 2002, 277:1828-1836.
20. Lin S.K., Chang H.H., Chen Y.J., et al. Epigallocatechin-3-gallate diminishes CCL2 expression in human osteoblastic cells via up-regulation of phosphatidylinositol 3-Kinase/Akt/Raf-1 interaction: a potential therapeutic benefit for arthritis. Arthritis. Rheum. 2008, 58:3145-3156.
21. Klinge C.M., Blankenship K.A., Risinger K.E., et al. Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells. J. Biol. Chem. 2005, 280:7460-7468.
22. Lee K.W., Kang N.J., Heo Y.S., et al. Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine. Cancer Res. 2008, 68:946-955.
23. Liang Y.C., Tsai S.H., Tsai D.C., et al. Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages. FEBS Lett. 2001, 496:12-18.
24. Kalra N., Seth K., Prasad S., et al. Theaflavins induced apoptosis of LNCaP cells is mediated through induction of p53, down-regulation of NF-kappa B and mitogen-activated protein kinases pathways. Life Sci. 2007, 80:2137-2146.
25. Yang Y.T., Weng C.J., Ho C.T., et al. Resveratrol analog-3,5,4'-trimethoxy-trans-stilbene inhibits invasion of human lung adenocarcinoma cells by suppressing the MAPK pathway and decreasing matrix metalloproteinase-2 expression. Mol. Nutr. Food Res. 2009, 53:407-416.
26. Kidd P.M. Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extracts. Altern. Med. Rev. 2009, 14:226-246.
27. Tachibana H., Koga K., Fujimura Y., et al. A receptor for green tea polyphenol EGCG. Nat. Struct. Mol. Biol. 2004, 11:380-381.
28. Fujimura Y., Umeda D., Yano S., et al. The 67kDa laminin receptor as a primary determinant of anti-allergic effects of O-methylated EGCG. Biochem. Biophys. Res. Commun. 2007, 364:79-85.
29. Givant-Horwitz V., Davidson B., Reich R. Laminin-induced signaling in tumor cells. Cancer Lett. 2005, 223:1-10.
30. Waite K.J., Floyd Z.E., Arbour-Reily P., et al. Interferon-gamma-induced regulation of peroxisome proliferator-activated receptor gamma and STATs in adipocytes. J. Biol. Chem. 2001, 276:7062-7068.
31. Hauser S., Adelmant G., Sarraf P. Degradation of the peroxisome proliferator-activated receptor gamma is linked to ligand-dependent activation. J. Biol. Chem. 2000, 275:18527-18533.