Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 24, 2010, Pages 7216-7221

  Zhao, Lianyun ^a   Zhang, Yingxin ^a   Dai, Chaoyang ^a   Guzi, Timothy ^a   Wiswell, Derek ^a   Seghezzi, Wolfgang ^a   Parry, David ^a   Fischmann, Thierry ^a   Siddiqui, M Arshad ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antitutor agent; CHK1 inhibitors; Kinase inhibitor; Thienopyridines

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHECKPOINT KINASE 1; PROTEIN SERINE THREONINE KINASE INHIBITOR; THIENOPYRIDINE DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; HYDROGEN BOND; IC 50; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIENOPYRIDINES; THIOPHENES;

EID: 78449301084     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.105     Document Type: Article

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24. free = 21.3%) for compounds 1, 2a and 70, respectively. The respective PDB access codes are 3PA3, 3PA4 and 3PA5.
25. 50 values were derived by nonlinear regression analysis.