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Volumn 345, Issue 1-2, 2010, Pages 29-34

The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor

Author keywords

A172 glioma cells; Anticancer drugs; Na K ATPase; Perillyl alcohol

Indexed keywords

4 NITROPHENYLPHOSPHATASE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) INHIBITOR; OUABAIN; PERILLYL ALCOHOL;

EID: 78449294127     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0556-9     Document Type: Article
Times cited : (33)

References (39)
  • 1
    • 0001409028 scopus 로고
    • The influence of some cations on an adenosine triphosphatase from peripheral nerves
    • 1:CAS:528:DyaG2sXjs1aitQ%3D%3D 10.1016/0006-3002(57)90343-8 13412736
    • JC Skou 1957 The influence of some cations on an adenosine triphosphatase from peripheral nerves Biochim Biophys Acta 23 394 401 1:CAS:528: DyaG2sXjs1aitQ%3D%3D 10.1016/0006-3002(57)90343-8 13412736
    • (1957) Biochim Biophys Acta , vol.23 , pp. 394-401
    • Skou, J.C.1
  • 2
    • 0032129846 scopus 로고    scopus 로고
    • The identification of the sodium pump
    • 1:CAS:528:DyaK1MXhtFChtw%3D%3D 10.1023/A:1020196612909 9877230
    • JC Skou 1998 The identification of the sodium pump Biosci Rep 18 155 169 1:CAS:528:DyaK1MXhtFChtw%3D%3D 10.1023/A:1020196612909 9877230
    • (1998) Biosci Rep , vol.18 , pp. 155-169
    • Skou, J.C.1
  • 3
    • 33846011388 scopus 로고    scopus 로고
    • New roles for an old enzyme: Na, K-ATPase emerges as an interesting drug target
    • 1:CAS:528:DC%2BD2sXislWhsbo%3D 10.1111/j.1365-2796.2006.01745.x 17222167
    • A Aperia 2007 New roles for an old enzyme: Na, K-ATPase emerges as an interesting drug target J Intern Med 261 44 52 1:CAS:528:DC%2BD2sXislWhsbo%3D 10.1111/j.1365-2796.2006.01745.x 17222167
    • (2007) J Intern Med , vol.261 , pp. 44-52
    • Aperia, A.1
  • 4
    • 33751011645 scopus 로고    scopus 로고
    • Na+, K+-ATPase: An indispensable ion pumping-signaling mechanism across mammalian cell membranes
    • 1:CAS:528:DC%2BD28Xht12hsbnO 10.1016/j.semnephrol.2006.07.002 17071332
    • AA Jaitovich AM Bertorello 2006 Na+, K+-ATPase: an indispensable ion pumping-signaling mechanism across mammalian cell membranes Semin Nephrol 26 386 392 1:CAS:528:DC%2BD28Xht12hsbnO 10.1016/j.semnephrol.2006.07.002 17071332
    • (2006) Semin Nephrol , vol.26 , pp. 386-392
    • Jaitovich, A.A.1    Bertorello, A.M.2
  • 5
    • 0642375802 scopus 로고    scopus 로고
    • Na(+), K(+)-ATPase: The new face of an old player in pathogenesis and apoptotic/hybrid cell death
    • 1:CAS:528:DC%2BD3sXnvVeqsL0%3D 10.1016/S0006-2952(03)00531-8 14555240
    • SP Yu 2003 Na(+), K(+)-ATPase: the new face of an old player in pathogenesis and apoptotic/hybrid cell death Biochem Pharmacol 66 1601 1609 1:CAS:528:DC%2BD3sXnvVeqsL0%3D 10.1016/S0006-2952(03)00531-8 14555240
    • (2003) Biochem Pharmacol , vol.66 , pp. 1601-1609
    • Yu, S.P.1
  • 6
    • 33645228747 scopus 로고    scopus 로고
    • Sodium/potassium ATPase (Na+, K+-ATPase) and ouabain/related cardiac glycosides: A new paradigm for development of anti-breast cancer drugs?
    • 1:CAS:528:DC%2BD28XivVentr8%3D 10.1007/s10549-005-9053-3 16322895
    • JQ Chen RG Contreras R Wang SV Fernandez L Shoshani IH Russo M Cereijido J Russo 2006 Sodium/potassium ATPase (Na+, K+-ATPase) and ouabain/related cardiac glycosides: a new paradigm for development of anti-breast cancer drugs? Breast Cancer Res Treat 96 1 15 1:CAS:528:DC%2BD28XivVentr8%3D 10.1007/s10549-005-9053-3 16322895
    • (2006) Breast Cancer Res Treat , vol.96 , pp. 1-15
    • Chen, J.Q.1    Contreras, R.G.2    Wang, R.3    Fernandez, S.V.4    Shoshani, L.5    Russo, I.H.6    Cereijido, M.7    Russo, J.8
  • 9
    • 0030926114 scopus 로고    scopus 로고
    • Alterations in alpha subunit expression of cardiac Na+, K+-ATPase in spontaneously hypertensive rats: Effect of antihypertensive therapy
    • 1:CAS:528:DyaK2sXjtlWnt7k%3D 10.1016/S0014-2999(97)89654-9 9200553
    • X Liu E Songu-Mize 1997 Alterations in alpha subunit expression of cardiac Na+, K+-ATPase in spontaneously hypertensive rats: effect of antihypertensive therapy Eur J Pharmacol 327 151 156 1:CAS:528: DyaK2sXjtlWnt7k%3D 10.1016/S0014-2999(97)89654-9 9200553
    • (1997) Eur J Pharmacol , vol.327 , pp. 151-156
    • Liu, X.1    Songu-Mize, E.2
  • 10
    • 0030962512 scopus 로고    scopus 로고
    • Purification and characterization of a Na+, K+ ATPase inhibitor found in an endotoxin of Leptospira interrogans
    • 1:CAS:528:DyaK2sXit12itr0%3D 9119504
    • P Burth M Younes-Ibrahim FH Goncalez ER Costa MV Faria 1997 Purification and characterization of a Na+, K+ ATPase inhibitor found in an endotoxin of Leptospira interrogans Infect Immun 65 1557 1560 1:CAS:528:DyaK2sXit12itr0%3D 9119504
    • (1997) Infect Immun , vol.65 , pp. 1557-1560
    • Burth, P.1    Younes-Ibrahim, M.2    Goncalez, F.H.3    Costa, E.R.4    Faria, M.V.5
  • 11
    • 0033129591 scopus 로고    scopus 로고
    • Is digitalis a therapy for breast carcinoma?
    • 1:STN:280:DyaK1M3itF2isQ%3D%3D 10203580
    • B Stenkvist 1999 Is digitalis a therapy for breast carcinoma? Oncol Rep 6 493 496 1:STN:280:DyaK1M3itF2isQ%3D%3D 10203580
    • (1999) Oncol Rep , vol.6 , pp. 493-496
    • Stenkvist, B.1
  • 12
    • 14944384159 scopus 로고    scopus 로고
    • Digitalis-induced signaling by Na+/K+-ATPase in human breast cancer cells
    • 1:CAS:528:DC%2BD2MXitlaqtrw%3D 10.1124/mol.104.007302 15602003
    • P Kometiani L Liu A Askari 2005 Digitalis-induced signaling by Na+/K+-ATPase in human breast cancer cells Mol Pharmacol 67 929 936 1:CAS:528:DC%2BD2MXitlaqtrw%3D 10.1124/mol.104.007302 15602003
    • (2005) Mol Pharmacol , vol.67 , pp. 929-936
    • Kometiani, P.1    Liu, L.2    Askari, A.3
  • 13
    • 40149110392 scopus 로고    scopus 로고
    • The sodium pump alpha1 subunit as a potential target to combat apoptosis-resistant glioblastomas
    • 1:CAS:528:DC%2BD1cXltleitL8%3D 18323016
    • F Lefranc R Kiss 2008 The sodium pump alpha1 subunit as a potential target to combat apoptosis-resistant glioblastomas Neoplasia 10 198 206 1:CAS:528:DC%2BD1cXltleitL8%3D 18323016
    • (2008) Neoplasia , vol.10 , pp. 198-206
    • Lefranc, F.1    Kiss, R.2
  • 16
    • 34047226362 scopus 로고    scopus 로고
    • Cardiac glycosides in cancer research and cancer therapy
    • K Winnick K Bielawski A Bielawski 2006 Cardiac glycosides in cancer research and cancer therapy Acta Pol Pharm 63 109 115
    • (2006) Acta Pol Pharm , vol.63 , pp. 109-115
    • Winnick, K.1    Bielawski, K.2    Bielawski, A.3
  • 17
    • 56249086846 scopus 로고    scopus 로고
    • Na+/K+-ATPase alpha subunits as new targets in anticancer therapy
    • 1:CAS:528:DC%2BD1cXht1egt7bO 10.1517/14728222.12.11.1403 18851696
    • T Mijatovic L Ingrassia V Facchini R Kiss 2008 Na+/K+-ATPase alpha subunits as new targets in anticancer therapy Expert Opin Ther Targets 12 1403 1417 1:CAS:528:DC%2BD1cXht1egt7bO 10.1517/14728222.12.11.1403 18851696
    • (2008) Expert Opin Ther Targets , vol.12 , pp. 1403-1417
    • Mijatovic, T.1    Ingrassia, L.2    Facchini, V.3    Kiss, R.4
  • 18
    • 1842737653 scopus 로고    scopus 로고
    • Up-regulation of Na(+), K(+)-ATPase alpha 3-isoform and down-regulation of the alpha1-isoform in human colorectal cancer
    • 1:CAS:528:DC%2BD2cXivVGgsr8%3D 10.1016/S0014-5793(04)00292-3 15063740
    • H Sakai T Suzuki M Maeda Y Takahashi N Horikawa T Minamimura K Tsukada N Takeguchi 2004 Up-regulation of Na(+), K(+)-ATPase alpha 3-isoform and down-regulation of the alpha1-isoform in human colorectal cancer FEBS Lett 563 151 154 1:CAS:528:DC%2BD2cXivVGgsr8%3D 10.1016/S0014-5793(04)00292-3 15063740
    • (2004) FEBS Lett , vol.563 , pp. 151-154
    • Sakai, H.1    Suzuki, T.2    Maeda, M.3    Takahashi, Y.4    Horikawa, N.5    Minamimura, T.6    Tsukada, K.7    Takeguchi, N.8
  • 19
    • 0142074249 scopus 로고    scopus 로고
    • Monoterpene regulation of Ras and Ras-related protein expression
    • 1:CAS:528:DC%2BD3sXltFars7k%3D 10.1194/jlr.M300057-JLR200 12671036
    • SA Holstein RJ Hohl 2003 Monoterpene regulation of Ras and Ras-related protein expression J Lipid Res 44 1209 1215 1:CAS:528:DC%2BD3sXltFars7k%3D 10.1194/jlr.M300057-JLR200 12671036
    • (2003) J Lipid Res , vol.44 , pp. 1209-1215
    • Holstein, S.A.1    Hohl, R.J.2
  • 20
    • 25144436538 scopus 로고    scopus 로고
    • Perillyl alcohol induces apoptosis in human glioblastoma multiforme cells
    • 1:CAS:528:DC%2BD2MXktVOht7w%3D 15809762
    • J Fernandes CO da Fonseca A Teixeira CR Gattass 2005 Perillyl alcohol induces apoptosis in human glioblastoma multiforme cells Oncol Rep 13 943 947 1:CAS:528:DC%2BD2MXktVOht7w%3D 15809762
    • (2005) Oncol Rep , vol.13 , pp. 943-947
    • Fernandes, J.1    Da Fonseca, C.O.2    Teixeira, A.3    Gattass, C.R.4
  • 21
    • 10744230271 scopus 로고    scopus 로고
    • Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: Potential mechanisms for its chemotherapeutic effects
    • 1:CAS:528:DC%2BD2cXhslels74%3D 10.1016/j.taap.2003.11.013
    • M Xu HS Floyd SM Greth WL Chang K Lohman R Stoyanova GL Kucera TE Kute MC Willingham MS Miller 2004 Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects Toxicol Applied Pharmacol 195 232 246 1:CAS:528:DC%2BD2cXhslels74%3D 10.1016/j.taap.2003.11.013
    • (2004) Toxicol Applied Pharmacol , vol.195 , pp. 232-246
    • Xu, M.1    Floyd, H.S.2    Greth, S.M.3    Chang, W.L.4    Lohman, K.5    Stoyanova, R.6    Kucera, G.L.7    Kute, T.E.8    Willingham, M.C.9    Miller, M.S.10
  • 22
    • 35148831822 scopus 로고    scopus 로고
    • Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells
    • 1:CAS:528:DC%2BD2sXhtFGkt7nK 10.1016/j.canlet.2007.07.020 17888568
    • L Yeruva KJ Pierre A Elegbede RC Wang SW Carper 2007 Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells Cancer Lett 257 216 226 1:CAS:528:DC%2BD2sXhtFGkt7nK 10.1016/j.canlet.2007.07.020 17888568
    • (2007) Cancer Lett , vol.257 , pp. 216-226
    • Yeruva, L.1    Pierre, K.J.2    Elegbede, A.3    Wang, R.C.4    Carper, S.W.5
  • 23
    • 30944451546 scopus 로고    scopus 로고
    • Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol
    • 2-1:8 (discussion S1:8-1:9)
    • Da Fonseca CO, Landeiro JA, Clark SS, Quirico-Santos T, da Costa Carvalho Mda G, Gattass CR (2006) Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol. Surg Neurol 65(suppl 1):S1:2-1:8 (discussion S1:8-1:9)
    • (2006) Surg Neurol , vol.65 , Issue.SUPPL. 1
    • Da Fonseca, C.O.1    Landeiro, J.A.2    Clark, S.S.3    Quirico-Santos, T.4    Da Costa Carvalho Mda, G.5    Gattass, C.R.6
  • 24
    • 70450279097 scopus 로고    scopus 로고
    • Correlation of tumor topography and peritumoral edema of recurrent malignant gliomas with therapeutic response to intranasal administration of perillyl alcohol
    • 10.1007/s10637-008-9215-3
    • CO Da Fonseca JT Silva IR Lins M Simao A Arnobio D Futuro T Quirico-Santos 2009 Correlation of tumor topography and peritumoral edema of recurrent malignant gliomas with therapeutic response to intranasal administration of perillyl alcohol Invest New Drugs 27 557 564 10.1007/s10637-008-9215-3
    • (2009) Invest New Drugs , vol.27 , pp. 557-564
    • Da Fonseca, C.O.1    Silva, J.T.2    Lins, I.R.3    Simao, M.4    Arnobio, A.5    Futuro, D.6    Quirico-Santos, T.7
  • 25
    • 0017610498 scopus 로고
    • Purification and characterization of (Na+ + K+)-ATPase. VI. Differential tryptic modification of catalytic functions of the purified enzyme in presence of NaCl and KCl
    • 1:STN:280:DyaE2s7lsl2isw%3D%3D 10.1016/0005-2736(77)90211-5 139923
    • PL Jorgensen 1977 Purification and characterization of (Na+ + K+)-ATPase. VI. Differential tryptic modification of catalytic functions of the purified enzyme in presence of NaCl and KCl Biochim Biophys Acta 466 97 108 1:STN:280:DyaE2s7lsl2isw%3D%3D 10.1016/0005-2736(77)90211-5 139923
    • (1977) Biochim Biophys Acta , vol.466 , pp. 97-108
    • Jorgensen, P.L.1
  • 26
    • 10244228011 scopus 로고    scopus 로고
    • Development of an HTS assay for Na +, K + -ATPase using nonradioactive rubidium ion uptake
    • 1:CAS:528:DC%2BD2cXhtVehtb7F 15671651
    • S Gill R Gill D Wicks S Despotovski D Liang 2004 Development of an HTS assay for Na +, K + -ATPase using nonradioactive rubidium ion uptake Assay Drug Dev Technol 2 535 542 1:CAS:528:DC%2BD2cXhtVehtb7F 15671651
    • (2004) Assay Drug Dev Technol , vol.2 , pp. 535-542
    • Gill, S.1    Gill, R.2    Wicks, D.3    Despotovski, S.4    Liang, D.5
  • 28
    • 0346037248 scopus 로고    scopus 로고
    • A comparative study between a brain Na+, K(+)-ATPase inhibitor (endobain E) and ascorbic acid
    • Rodriguez de Lores Arnaiz G, Herbin T, Pena C (2003) A comparative study between a brain Na+, K(+)-ATPase inhibitor (endobain E) and ascorbic acid. Neurochem Res 28:903-910
    • (2003) Neurochem Res , vol.28 , pp. 903-910
    • Rodriguez De Lores Arnaiz, G.1    Herbin, T.2    Pena, C.3
  • 29
    • 67650169864 scopus 로고    scopus 로고
    • Inhibition of mammal Na(+) K(+)-ATPase by diterpenes extracted from the Brazilian brown alga Dictyota cervicornis
    • 1:CAS:528:DC%2BD1MXps1Wjtb8%3D 10.1002/ptr.2600 19142983
    • DG Garcia EM Bianco C Santos Mda RC Pereira MV Faria VL Teixeira P Burth 2009 Inhibition of mammal Na(+) K(+)-ATPase by diterpenes extracted from the Brazilian brown alga Dictyota cervicornis Phytother Res 23 943 947 1:CAS:528:DC%2BD1MXps1Wjtb8%3D 10.1002/ptr.2600 19142983
    • (2009) Phytother Res , vol.23 , pp. 943-947
    • Garcia, D.G.1    Bianco, E.M.2    Santos Mda, C.3    Pereira, R.C.4    Faria, M.V.5    Teixeira, V.L.6    Burth, P.7
  • 32
    • 0029125753 scopus 로고
    • Differential effects of monoterpenes and lovastatin on RAS processing
    • 1:CAS:528:DyaK2MXntVOrtbc%3D 10.1074/jbc.270.29.17508 7615555
    • RJ Hohl K Lewis 1995 Differential effects of monoterpenes and lovastatin on RAS processing J Biol Chem 270 17508 17512 1:CAS:528:DyaK2MXntVOrtbc%3D 10.1074/jbc.270.29.17508 7615555
    • (1995) J Biol Chem , vol.270 , pp. 17508-17512
    • Hohl, R.J.1    Lewis, K.2
  • 33
    • 0031841099 scopus 로고    scopus 로고
    • Effects of the antitumor agent perillyl alcohol on H-Ras versus K-Ras farnesylation and signal transduction in pancreatic cells
    • 1:CAS:528:DyaK1cXjvFKgtro%3D 9615726
    • KR Stayrook JH McKinzie LH Barbhaiya PL Crowell 1998 Effects of the antitumor agent perillyl alcohol on H-Ras versus K-Ras farnesylation and signal transduction in pancreatic cells Anticancer Res 18 823 828 1:CAS:528: DyaK1cXjvFKgtro%3D 9615726
    • (1998) Anticancer Res , vol.18 , pp. 823-828
    • Stayrook, K.R.1    McKinzie, J.H.2    Barbhaiya, L.H.3    Crowell, P.L.4
  • 34
    • 34249991729 scopus 로고    scopus 로고
    • Ouabain activates signaling pathways associated with cell death in human neuroblastoma
    • 1:CAS:528:DC%2BD2sXmsFKrt7c%3D 10.1016/j.bbamem.2007.04.012 17524349
    • A Kulikov A Eva U Kirch A Boldyrev G Scheiner-Bobis 2007 Ouabain activates signaling pathways associated with cell death in human neuroblastoma Biochim Biophys Acta 1768 1691 1702 1:CAS:528:DC%2BD2sXmsFKrt7c%3D 10.1016/j.bbamem.2007.04.012 17524349
    • (2007) Biochim Biophys Acta , vol.1768 , pp. 1691-1702
    • Kulikov, A.1    Eva, A.2    Kirch, U.3    Boldyrev, A.4    Scheiner-Bobis, G.5
  • 35
    • 55349103358 scopus 로고    scopus 로고
    • Novel therapeutic applications of cardiac glycosides
    • 1:CAS:528:DC%2BD1cXhtlSktLnE 10.1038/nrd2682 18948999
    • I Prassas EP Diamandis 2008 Novel therapeutic applications of cardiac glycosides Nat Rev Drug Discov 7 926 935 1:CAS:528:DC%2BD1cXhtlSktLnE 10.1038/nrd2682 18948999
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 926-935
    • Prassas, I.1    Diamandis, E.P.2
  • 36
    • 2342487353 scopus 로고    scopus 로고
    • Na/K ATPase mediated signal transduction: From protein interaction to cellular function
    • 1:CAS:528:DC%2BD3sXkslWqs74%3D 10.1124/mi.3.3.157 14993422
    • Z Xie T Cai 2003 Na/K ATPase mediated signal transduction: from protein interaction to cellular function Mol Interv 3 157 164 1:CAS:528: DC%2BD3sXkslWqs74%3D 10.1124/mi.3.3.157 14993422
    • (2003) Mol Interv , vol.3 , pp. 157-164
    • Xie, Z.1    Cai, T.2
  • 37
    • 29044433675 scopus 로고    scopus 로고
    • Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients
    • 1:CAS:528:DC%2BD2MXhtFWku7fM 10.1021/np050226l 16309315
    • M Lopez-Lazaro N Pastor SS Azrak MJ Ayuso CA Austin F Cortes 2005 Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients J Nat Prod 68 1642 1645 1:CAS:528:DC%2BD2MXhtFWku7fM 10.1021/np050226l 16309315
    • (2005) J Nat Prod , vol.68 , pp. 1642-1645
    • Lopez-Lazaro, M.1    Pastor, N.2    Azrak, S.S.3    Ayuso, M.J.4    Austin, C.A.5    Cortes, F.6
  • 39
    • 2342424240 scopus 로고    scopus 로고
    • Ouabain assembles signaling cascades through the caveolar Na+/K+-ATPase
    • 1:CAS:528:DC%2BD2cXjt1Gnsrw%3D 10.1074/jbc.M313239200 14963033
    • H Wang M Haas M Liang T Cai J Tian S Li Z Xie 2004 Ouabain assembles signaling cascades through the caveolar Na+/K+-ATPase J Biol Chem 279 17250 17259 1:CAS:528:DC%2BD2cXjt1Gnsrw%3D 10.1074/jbc.M313239200 14963033
    • (2004) J Biol Chem , vol.279 , pp. 17250-17259
    • Wang, H.1    Haas, M.2    Liang, M.3    Cai, T.4    Tian, J.5    Li, S.6    Xie, Z.7


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