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Volumn 18, Issue 2 A, 1998, Pages 823-828

Effects of the antitumor agent perillyl alcohol on H-Ras vs. K-Ras farnesylation and signal transduction in pancreatic cells

Author keywords

Chemotherapy; MAP kinase; Monoterpene; Pancreatic neoplasm

Indexed keywords

ANTINEOPLASTIC AGENT; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; PERILLYL ALCOHOL; RAS PROTEIN; UNCLASSIFIED DRUG;

EID: 0031841099     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (46)

References (37)
  • 1
  • 2
    • 0027153103 scopus 로고
    • Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
    • Buday L, Downward J: Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73: 611-620, 1993.
    • (1993) Cell , vol.73 , pp. 611-620
    • Buday, L.1    Downward, J.2
  • 4
    • 0031043776 scopus 로고    scopus 로고
    • Signal transduction from multiple Ras effectors
    • Katz ME, McCormick F: Signal transduction from multiple Ras effectors. Curr Opin Genetics Dev 7: 75-79, 1997.
    • (1997) Curr Opin Genetics Dev , vol.7 , pp. 75-79
    • Katz, M.E.1    McCormick, F.2
  • 6
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos JL: Ras oncogenes in human cancer: a review. Cancer Res 49: 4682-4689, 1989.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 7
    • 0029898894 scopus 로고    scopus 로고
    • Protein prenylation: Molecular mechanisms and functional consequences
    • Zhang FL, Casey PJ: Protein prenylation: molecular mechanisms and functional consequences. Ann Rev Biochem 65: 241-269, 1996.
    • (1996) Ann Rev Biochem , vol.65 , pp. 241-269
    • Zhang, F.L.1    Casey, P.J.2
  • 8
    • 0026747866 scopus 로고
    • Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity
    • Kato K, Cox AD, Hisaka MM, Graham SM, Buss JE, Der CJ: Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc Natl Acad Sci USA 89: 6403-6407, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6403-6407
    • Kato, K.1    Cox, A.D.2    Hisaka, M.M.3    Graham, S.M.4    Buss, J.E.5    Der, C.J.6
  • 9
    • 0027447863 scopus 로고
    • The post-translational processing of ras p21 is critical for its stimulation of mitogen-activated protein kinase
    • Itoh T, Kaibuchi K, Masuda T, Yamamoto T, Matsuura Y, Maeda A, Shimizu K, Takai Y: The post-translational processing of ras p21 is critical for its stimulation of mitogen-activated protein kinase. J Biol Chem 26: 3025-3028, 1993.
    • (1993) J Biol Chem , vol.26 , pp. 3025-3028
    • Itoh, T.1    Kaibuchi, K.2    Masuda, T.3    Yamamoto, T.4    Matsuura, Y.5    Maeda, A.6    Shimizu, K.7    Takai, Y.8
  • 10
    • 0027964170 scopus 로고
    • The post-translational modification of Ras p21 is important for Raf-1 activation
    • Kikuchi A, Williams LT: The post-translational modification of Ras p21 is important for Raf-1 activation. J Biol Chem 269: 20054-20059, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 20054-20059
    • Kikuchi, A.1    Williams, L.T.2
  • 11
    • 0028122345 scopus 로고
    • Prenylation of ras proteins is required for efficient hSOS1-promoted guanine nucleotide exchange
    • Porfiri E, Evans T, Chardin P, Hancock JF: Prenylation of ras proteins is required for efficient hSOS1-promoted guanine nucleotide exchange. J Biol Chem 269: 22672-22677, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 22672-22677
    • Porfiri, E.1    Evans, T.2    Chardin, P.3    Hancock, J.F.4
  • 12
    • 0027213688 scopus 로고
    • Inhibitors of Ras farnesyltransferases
    • Tamanoi F: Inhibitors of Ras farnesyltransferases. Trends in Biochem. Sci 18: 349-353, 1993.
    • (1993) Trends in Biochem. Sci , vol.18 , pp. 349-353
    • Tamanoi, F.1
  • 13
    • 0029812287 scopus 로고    scopus 로고
    • Rational design of Ras prenyltransferase inhibtors as potent anticancer drugs
    • Sebti SM, Hamilton AD: Rational design of Ras prenyltransferase inhibtors as potent anticancer drugs. Biochem Soc Trans 24: 692-699, 1996.
    • (1996) Biochem Soc Trans , vol.24 , pp. 692-699
    • Sebti, S.M.1    Hamilton, A.D.2
  • 16
    • 0029055687 scopus 로고
    • The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and periilyl alcohol
    • Gelb MH, Tamanoi F, Yokoyama K, Ghomashchi F, Esson K, Gould MN: The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and periilyl alcohol. Cancer Lett 91: 169-175, 1995.
    • (1995) Cancer Lett , vol.91 , pp. 169-175
    • Gelb, M.H.1    Tamanoi, F.2    Yokoyama, K.3    Ghomashchi, F.4    Esson, K.5    Gould, M.N.6
  • 17
    • 0028343655 scopus 로고
    • Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation
    • Crowell PL, Ren Z, Lin S, Vedejs E, Gould MN: Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation. Biochemical Pharmacol 47: 1405-1415, 1994.
    • (1994) Biochemical Pharmacol , vol.47 , pp. 1405-1415
    • Crowell, P.L.1    Ren, Z.2    Lin, S.3    Vedejs, E.4    Gould, M.N.5
  • 18
    • 0025952954 scopus 로고
    • Selective inhibition of isoprenylation of 21-26 kDa proteins by the anticarcinogen d-limonene and its metabolites
    • Crowell PL, Chang RR, Ren Z, Elson CE, Gould MN: Selective inhibition of isoprenylation of 21-26 kDa proteins by the anticarcinogen d-limonene and its metabolites. J Biol Chem 266: 17679-17685, 1991.
    • (1991) J Biol Chem , vol.266 , pp. 17679-17685
    • Crowell, P.L.1    Chang, R.R.2    Ren, Z.3    Elson, C.E.4    Gould, M.N.5
  • 20
    • 0027965512 scopus 로고
    • Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene
    • Haag JD, Gould MN: Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene. Cancer Chemother Pharmacol 34: 477-483, 1994.
    • (1994) Cancer Chemother Pharmacol , vol.34 , pp. 477-483
    • Haag, J.D.1    Gould, M.N.2
  • 21
    • 0028928294 scopus 로고
    • Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol
    • Mills JJ, Chari RS, Boyer IJ, Gould MN, Jirtle RL: Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. Cancer Res 55: 979-983, 1995.
    • (1995) Cancer Res , vol.55 , pp. 979-983
    • Mills, J.J.1    Chari, R.S.2    Boyer, I.J.3    Gould, M.N.4    Jirtle, R.L.5
  • 25
    • 0025116067 scopus 로고
    • Characterization of differentiated Syrian golden hamster pancreatic duct cells maintained in extended monolayer culture
    • Hubchak S, Mangino MM, Reddy MK, Scarpelli DG: Characterization of differentiated Syrian golden hamster pancreatic duct cells maintained in extended monolayer culture. In Vitro Cell Devel Biol 26: 889-897, 1990.
    • (1990) In Vitro Cell Devel Biol , vol.26 , pp. 889-897
    • Hubchak, S.1    Mangino, M.M.2    Reddy, M.K.3    Scarpelli, D.G.4
  • 26
    • 0027978836 scopus 로고
    • In vitro carcinogenesis of hamster pancreatic duct cells: Cellular and molecular alterations
    • Mangold KA, Hubchak S, Mangino MM, Laconi S, Scarpelli DG: In vitro carcinogenesis of hamster pancreatic duct cells: cellular and molecular alterations. Carcinogenesis 15: 1979-1984, 1994.
    • (1994) Carcinogenesis , vol.15 , pp. 1979-1984
    • Mangold, K.A.1    Hubchak, S.2    Mangino, M.M.3    Laconi, S.4    Scarpelli, D.G.5
  • 28
    • 0028113884 scopus 로고
    • R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells
    • Cox AD, Brtva TR, Lowe DG, Der CJ: R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells. Oncogene 9: 3281-3288, 1994.
    • (1994) Oncogene , vol.9 , pp. 3281-3288
    • Cox, A.D.1    Brtva, T.R.2    Lowe, D.G.3    Der, C.J.4
  • 29
    • 0028800305 scopus 로고
    • Activation of Racl, RhoA, and mitogen-activated protein kinases is required for Ras transformation
    • Khosravi-Far R, Solski PA, Clark GJ, Kinch MS, Der CJ: Activation of Racl, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol Cell Biol 15: 6443-6453, 1995.
    • (1995) Mol Cell Biol , vol.15 , pp. 6443-6453
    • Khosravi-Far, R.1    Solski, P.A.2    Clark, G.J.3    Kinch, M.S.4    Der, C.J.5
  • 30
    • 0028892646 scopus 로고
    • Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity
    • Lebowitz PF, Davide JP, Prcndergast GC: Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity. Mol Cell Biol 15: 6613-6622, 1995.
    • (1995) Mol Cell Biol , vol.15 , pp. 6613-6622
    • Lebowitz, P.F.1    Davide, J.P.2    Prcndergast, G.C.3
  • 31
  • 32
    • 0029101360 scopus 로고
    • An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1
    • Olson MF, Ashworth A, Hall: An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269: 1270-1272, 1995.
    • (1995) Science , vol.269 , pp. 1270-1272
    • Olson, M.F.1    Ashworth, A.2    Hall3
  • 33
    • 0029664317 scopus 로고    scopus 로고
    • Resistance of K-RasBV12 proteins to farnesyl-transferase inhibitors in Ratl cells
    • James G, Goldstein JL, Brown MS: Resistance of K-RasBV12 proteins to farnesyl-transferase inhibitors in Ratl cells. Proc Natl Acad Sci. USA 93: 4454-4458, 1996.
    • (1996) Proc Natl Acad Sci. USA , vol.93 , pp. 4454-4458
    • James, G.1    Goldstein, J.L.2    Brown, M.S.3
  • 34
    • 0030943198 scopus 로고    scopus 로고
    • Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase
    • Zhang FL, Kirschmeier P, Can D, James L, Bond RW, Wang L, Patton R, Windsor WT, Syto R, Zhang R, Bishop WR: Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase. J Biol Chem 272: 10232-10239, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 10232-10239
    • Zhang, F.L.1    Kirschmeier, P.2    Can, D.3    James, L.4    Bond, R.W.5    Wang, L.6    Patton, R.7    Windsor, W.T.8    Syto, R.9    Zhang, R.10    Bishop, W.R.11
  • 35
    • 0028958919 scopus 로고
    • Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro
    • James GL, Goldstein JL, Brown MS: Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro. J Biol Chem 270: 6221-6226, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 6221-6226
    • James, G.L.1    Goldstein, J.L.2    Brown, M.S.3
  • 36
    • 0028810275 scopus 로고
    • Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyl transferase inhibitor
    • Lerner EC, Qian Y, Hamilton AD, Sebti SM: Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyl transferase inhibitor. J Biol Chem 270: 26770-26773, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 26770-26773
    • Lerner, E.C.1    Qian, Y.2    Hamilton, A.D.3    Sebti, S.M.4
  • 37
    • 0028884084 scopus 로고
    • Evidence for cell-specific differences in transformation by N-, H- and K-ras
    • Maher J, Baker DA, Manning M, Dibb NJ, Roberts IAG: Evidence for cell-specific differences in transformation by N-, H- and K-ras. Oncogene 11: 1639-1647, 1995.
    • (1995) Oncogene , vol.11 , pp. 1639-1647
    • Maher, J.1    Baker, D.A.2    Manning, M.3    Dibb, N.J.4    Roberts, I.A.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.