Perillyl alcohol induces apoptosis in human glioblastoma multiforme cells

Oncology Reports

Volumn 13, Issue 5, 2005, Pages 943-947

  Fernandes, Janaína ^a   Da Fonseca, Clovis Orlando ^c   Teixeira, Anselmo ^b   Gattass, Cerli Rocha ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^c HOSPITAL UNIVERSITÁRIO ANTÔNIO PEDRO   (Brazil)

Author keywords

Apoptosis; Brain tumor; Farnesyl transferase inhibitor; Glioblastoma multiforme therapy; Perillyl alcohol

Indexed keywords

ANTINEOPLASTIC AGENT; PERILLYL ALCOHOL; TERPENE;

APOPTOSIS; ARTICLE; CELL CULTURE; DRUG EFFECT; GLIOBLASTOMA; HUMAN; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; GLIOBLASTOMA; HUMANS; MONOTERPENES; TUMOR CELLS, CULTURED;

EID: 25144436538     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.13.5.943     Document Type: Article

References (31)

1. Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC and Cavenee WK: The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61: 215-225, 2002. (Pubitemid 34212595)
2. Burger PC, Vogel FS, Green SB and Strike TA: Glioblastoma multiforme and anaplastic astrocitoma. Pathologic criteria and prognostic implications. Cancer 56: 1106-1111, 1985. (Pubitemid 15003495)
3. Stewart LA: Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomized trials. Lancet 359: 1011-1018, 2002.
4. Brandes AA, Vastola F, Basso U, Berti F, Pinna G, Rotilio A, Gardiman M, Scienza R, Monfardini S and Ermani M: A prospective study on glioblastoma in the elderly. Cancer 97: 657-662, 2003. (Pubitemid 36125843)
5. Konopka G and Bonni A: Signaling pathways regulating gliomagenesis. Current Mol Med 3: 73-84, 2003. (Pubitemid 36131679)
6. von Deimling A, Eibi RH, Ohgaki H, Louis DN, von Ammon K, Petersen I, Kleihues P, Chung RY, Wiestler OD and Seizinger BR: p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma. Cancer Res 52: 2987-2990, 1992.
7. Wong AJ, Ruppert JM, Bigner SH, Grzeschik CH, Humphrey PA, Bigner DS and Vogelstein B: Structural alterations of the epidermal growth factor receptor genes in human gliomas. Proc Natl Acad Sci USA 89: 2965-2969, 1992.
8. Guha A, Feldkamp MM, Lau N, Boss G and Pawson A: Proliferation of human malignant astrocytomas are dependent on Ras activation. Oncogene 15: 2755-2765, 1997. (Pubitemid 28004565)
9. Bredel M and Pollack IF: The p21-Ras signal transduction pathway and growth regulation in human high-grade gliomas. Brain Res Rev 29: 232-249, 1999. (Pubitemid 29191341)
10. Gibbs JB, Pompliano DL, Mosser SD, Rands E, Lingham RB, Singh SB, Scolnick EM, Kohl NE and Oliff A: Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. J Biol Chem 268: 7617-7620, 1993. (Pubitemid 23120323)
11. Feldkamp MM, Lau N and Guha A: Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptoic and anti-angiogenic effects. Oncogene 18: 7514-7526, 1999. (Pubitemid 30035052)
12. Crowell PL, Ren Z, Lin S, Vedejs E and Gould MN: Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation. Biochem Pharmacol 47: 1405-1415, 1994. (Pubitemid 24130935)
13. Mills JJ, Chad RS, Boyer IJ, Gould MN and Jirtle RL: Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. Cancer Res 55: 979-983, 1995.
14. Clark SS, Perman SM, Sahin MB, Jenkins GJ and Elegbede J A: Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl cells is to induce cell arrest. Leukemia 16: 213-222, 2002. (Pubitemid 34145139)
15. Stayrook KR, McKinzie JH, Barbhaiya LH and Crowell PL: Effects of antitumor agent perillyl alcohol on H-Ras vs K-ras farnesylation and signal transduction in pancreatic cells. Anticancer Res 18: 823-828, 1998. (Pubitemid 28239601)
16. Ariazi EA, Satomi Y, Ellis MJ, Haag JD, Shi W, Sattier CA and Gould MN: Activation of the transforming growth factor beta signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol. Cancer Res 59: 1917-1928, 1999. (Pubitemid 29186166)
17. Bardon S, Foussard V, Founel S and Loubat A: Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression. Cancer Lett 181: 187-194, 2002. (Pubitemid 34518303)
18. Rajesh D and Howard SP: Perillyl alcohol mediated radiosensitization via augmentation of the Fas pathway in prostate cancercells. Prostate 57: 14-23, 2003. (Pubitemid 37070145)
19. Teruszkin Balassiano I, de Paulo SA, Silva NH, Cabral CM, Gibaldi B, Bozza M, Fonseca CO, Da Costa MGC: Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model. Int J Mol Med 10: 785-788, 2002.
20. Rajesh D, Stenzel RA and Howard SP: Perillyl alcohol as a radio-/chemosensitizer in malignant glioma. J Biol Chem 19: 35968-35978, 2003. (Pubitemid 37139915)
21. Yuri T, Danbara N, Tsujita-Kyutoku M, Kiyozuka Y, Senzaki H, Shikata N, Kanzaki H and Tsubura A: Perillyl alcohol inhibits human breast cancer cell growth in vitro and in vivo. Breast Cancer Res Treat 84: 251-260, 2004. (Pubitemid 38445375)
22. Xu M, Floyd HS, Greth SM, Chang WC, Lohman K, Stoyanova R, Kucera GL, Kute TE, Willingham MC and Miller MS: Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation potential mechanisms for its chemotherapeutic effects. Toxicol Appl Pharmacol 195: 232-246, 2004. (Pubitemid 38293154)
23. Belanger JT: Perillyl alcohol: applications in oncology. Altern Med Rev 3: 448-457, 1998.
24. Barthelman M, Chen W, Gensler HL, Huang C, Dong Z and Bowden GT: Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation. Cancer Res 58: 711-716, 1998. (Pubitemid 28099482)
25. Reddy BS, Wang CX, Samaha H, Lubet R, Steele VE, Kelloff GJ and Rao CV: Chemoprevention of colon carcinogenesis by dietary perillyl alcohol. Cancer Res 57: 420-425, 1997. (Pubitemid 27081658)
26. Lantry LE, Zhang Z, Gao F, Crist KA, Wang Y, Kelloff GJ, Lubet RA and You M: Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung. J Cell Biochem 27:20-25, 1997. (Pubitemid 28222115)
27. Broitman SA, Wilkinson J IV, Cerda S and Branch SK: Effects of monoterpenes and mevinolin on murine colon tumor CT-26 in vitro and its hepatic 'metastases' in vivo. Adv Exp Med Biol 401: 111-130, 1996. (Pubitemid 26326195)
28. Azzoli CG, Miller VA, Ng KK, Krug LM, Spriggs DR, Tong WP, Riedel ER and Kris MG: A phase I trial of perillyl alcohol in patients with advanced solid tumors. Cancer Chemother Pharmacol 51: 493-498, 2003. (Pubitemid 36791675)
29. Meadows SM, Mulkerin D, Berlin J, Bailey H, Kolesar J, Warren D and Thomas JP: Phase II trial of perillyl alcohol in patients with metastatic coloretal cancer. Int J Gastrointest Cancer 32: 125-128, 2002. (Pubitemid 36749000)
30. Stayrook KR, McKinzie JH, Burke YD, Burke YA and Crowell PL: Induction of the apoptosis-promoting protein Bak by perillyl alcohol in pancreatic ductal adenocarcinoma relative to untransformed ductal epithelial cells. Carcinogenesis 18: 1655-1658, 1997. (Pubitemid 28134793)
31. McKeever PE, Davenport RD and Shakui P: Patterns of antigenic expression of human glioma cells. Crit Rev Neurobiol 6: 119-147, 1991.