Molecular basis for age-related changes in ileum: Involvement of Bax/caspase-dependent mitochondrial apoptotic signaling

Experimental Gerontology

Volumn 45, Issue 12, 2010, Pages 970-976

  Lee, Eun Kyeong ^a   Jung, Kyung Jin ^b   Choi, Jehun ^a   Kim, Hyun Jung ^a   Han, Yu Kyeong ^a   Jeong, Kyu Shik ^c   Ji, Ae Ri ^c   Park, Jin Kyu ^c   Yu, Byung Pal ^d   Chung, Hae Young ^a  

^a Pusan National University   (South Korea)

^b Korea Institute of Toxicology   (South Korea)

^c Kyungpook National University   (South Korea)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Aging; Apoptosis; Bax; Caspase; Ileum; Mitochondrial permeabilization; Oxidative stress

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; APOPTOSIS INDUCING FACTOR; CASPASE 3; CYCLOPHILIN D; ENDONUCLEASE G; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PROTEIN BAX; VOLTAGE DEPENDENT ANION CHANNEL;

AGE; AGING; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; DNA FRAGMENTATION; ILEUM; INTESTINE MUCOSA; MALE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION;

ADENINE NUCLEOTIDE TRANSLOCATOR 1; AGING; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CYCLOPHILINS; ILEUM; INTESTINAL MUCOSA; MALE; MITOCHONDRIA, MUSCLE; MODELS, ANIMAL; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; VOLTAGE-DEPENDENT ANION CHANNELS;

RATTUS;

EID: 78449285662     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2010.08.019     Document Type: Article

References (35)

1. Abu-Hamad S., Arbel N., Calo D., Arzoine L., Israelson A., Keinan N., Ben-Romano R., Friedman O., Shoshan-Barmatz V. The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins. J. Cell Sci. 2009, 122:1906-1916.
2. Armstrong J.S., Jones D.P. Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in HL60 cells that overexpress Bcl-2. FASEB J. 2002, 16:1263-1265.
3. Baines C.P., Kaiser R.A., Purcell N.H., Blair N.S., Osinska H., Hambleton M.A., Brunskill E.W., Sayen M.R., Gottlieb R.A., Dorn G.W., Robbins J., Molkentin J.D. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 2005, 31:658-662.
4. Barbouti A., Amorgianiotis C., Kolettas E., Kanavaros P., Galaris D. Hydrogen peroxide inhibits caspase-dependent apoptosis by inactivating procaspase-9 in an iron-dependent manner. Free Radic. Biol. Med. 2007, 43:1377-1387.
5. Belizário J.E., Alves J., Occhiucci J.M., Garay-Malpartida M., Sesso A. A mechanistic view of mitochondrial death decision pores. Braz. J. Med. Biol. Res. 2007, 40:1011-1024.
6. Brown G.C., Borutaite V. Regulation of apoptosis by the redox state of cytochrome c. Biochim. Biophys. Acta 2008, 1777:877-881.
7. Chung H.Y., Sung B., Jung K.J., Zou Y., Yu B.P. The molecular inflammatory process in aging. Antioxid. Redox Signal. 2006, 8:572-581.
8. Ciccocioppo R., Di Sabatino A., Luinetti O., Rossi M., Cifone M.G., Corazza G.R. Small bowel enterocyte apoptosis and proliferation are increased in the elderly. Gerontology 2002, 48:204-208.
9. Eskes R., Antonsson B., Osen-Sand A., Montessuit S., Richter C., Sadoul R., Mazzei G., Nichols A., Martinou J.C. Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions. J. Cell Biol. 1998, 143:217-224.
10. Fernández-Checa J.C. Redox regulation and signaling lipids in mitochondrial apoptosis. Biochem. Biophys. Res. Commun. 2003, 304:471-479.
11. Giam M., Huang D.C., Bouillet P. BH3-only proteins and their roles in programmed cell death. Oncogene 2008, 27:128-136.
12. Go E.K., Jung K.J., Kim J.M., Lim H., Lim H.K., Yu B.P., Chung H.Y. Betaine modulates age-related NF-kappaB by thiol-enhancing action. Biol. Pharm. Bull. 2007, 30:2244-2249.
13. Grattagliano I., Portincasa P., Cocco T., Moschetta A., Di Paola M., Palmieri V.O., Palasciano G. Effect of dietary restriction and N-acetylcysteine supplementation on intestinal mucosa and liver mitochondrial redox status and function in aged rats. Exp. Gerontol. 2004, 39:1323-1332.
14. Green D.R., Kroemer G. The pathophysiology of mitochondrial cell death. Science 2004, 305:626-629.
15. Hissin P.J., Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 1976, 74:214-226.
16. Kim J.S., He L., Qian T., Lemasters J.J. Role of the mitochondrial permeability transition in apoptotic and necrotic death after ischemia/reperfusion injury to hepatocytes. Curr. Mol. Med. 2003, 3:527-535.
17. Kim R., Emi M., Tanabe K. Role of mitochondria as the gardens of cell death. Cancer Chemother. Pharmacol. 2006, 57:545-553.
18. Maity P., Bindu S., Dey S., Goyal M., Alam A., Pal C., Mitra K., Bandyopadhyay U. Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel role of mitochondrial aconitase oxidation. J. Biol. Chem. 2009, 284:3058-3068.
19. Marzetti E., Wohlgemuth S.E., Lee H.A., Chung H.Y., Giovannini S., Leeuwenburgh C. Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle. Mech. Ageing Dev. 2008, 129:542-549.
20. Narita M., Shimizu S., Ito T., Chittenden T., Lutz R.J., Matsuda H., Tsujimoto Y. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc. Natl Acad. Sci. USA 1998, 95:14681-14686.
21. Nicholson D.W. Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ. 1999, 6:1028-1042.
22. Noda T., Iwakiri R., Fujimoto K., Yoshida T., Utsumi H., Sakata H., Hisatomi A., Aw T.Y. Suppression of apoptosis is responsible for increased thickness of intestinal mucosa in streptozotocin-induced diabetic rats. Metabolism 2001, 50:259-264.
23. Okouchi M., Okayama N., An T.Y. Differential susceptibility of native and differentiated PC-12 cells to metylglyoxal-induced apoptosis: influence of cellular redox. Curr. Neurovasc. Res. 2005, 2:13-22.
24. Ramachandran A., Madesh M., Balasubramanian K.A. Apoptosis in the intestinal epithelium: its relevance in normal and pathophysiological conditions. J. Gastroenterol. Hepatol. 2000, 15:109-200.
25. Rosa E.F., Silva A.C., Ihara S.S., Mora O.A., Aboulafia J., Nouailhetas V.L. Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging. J. Appl. Physiol. 2005, 99:1569-1575.
26. Shi Y., Chen J., Weng C., Chen R., Zheng Y., Chen Q., Tang H. Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins. Biochem. Biophys. Res. Commun. 2003, 305:989-996.
27. Smith D.J., Ng H., Kluck R.M., Nagley P. The mitochondrial gateway to cell death. IUBMB Life 2008, 60:383-389.
28. Susic D., Frohlich E.D. The aging hypertensive heart: a brief update. Nat. Clin. Pract. Cardiovasc. Med. 2008, 5:104-110.
29. Susnow N., Zeng L., Margineantu D., Hockenbery D.M. Bcl-2 family proteins as regulators of oxidative stress. Semin. Cancer Biol. 2009, 19:42-49.
30. Tait S.W., Green D.R. Caspase-independent cell death: leaving the set without the final cut. Oncogene 2008, 27:6452-6461.
31. Tsujimoto Y., Shimizu S. Role of the mitochondrial membrane permeability transition in cell death. Apoptosis 2007, 12:835-840.
32. Wang L., Li J., Li Q., Zhang J., Duan X.L. Morphological changes of cell proliferation and apoptosis in rat jejunal mucosa at different ages. World J. Gastroenterol. 2003, 9:2060-2064.
33. Yasuda T., Takeyama Y., Ueda T., Shinzeki M., Sawa H., Nakajima T., Kuroda Y. Breakdown of intestinal mucosa via accelerated apoptosis increases intestinal permeability in experimental severe acute pancreatitis. J. Surg. Res. 2006, 135:18-26.
34. Yoshida A., Pommier Y., Ueda T. Endonuclease activation and chromosomal DNA fragmentation during apoptosis in leukemia cells. Int. J. Hematol. 2006, 84:31-37.
35. Yu B.P. Membrane alteration as a basis of aging and the protective effects of calorie restriction. Mech. Ageing Dev. 2005, 126:1003-1010.