The krüppel-like factor 6 genotype is associated with gastric cancer in a chinese population

Journal of International Medical Research

Volumn 38, Issue 5, 2010, Pages 1801-1807

  Chen, H ^a   Chen, L ^b   Zhang, Q F ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Gastric cancer; Genetic polymorphism; Kr ppel like factor 6

Indexed keywords

KRUPPEL LIKE FACTOR 6;

ADULT; ARTICLE; CANCER CLASSIFICATION; CANCER LOCALIZATION; CANCER RISK; CANCER STAGING; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; FEMALE; GENE SEQUENCE; GENETIC ASSOCIATION; GENOTYPE; HISTOPATHOLOGY; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; SINGLE NUCLEOTIDE POLYMORPHISM; STOMACH CANCER;

EID: 78449268185     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323001003800527     Document Type: Article

References (35)

1. Parkin DM, Bray F, Ferlay J, et al: Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
2. Parkin DM, Bray F, Ferlay J, et al: Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001; 94: 153-156.
3. González CA, Sala N, Capellá G: Genetic susceptibility and gastric cancer risk. Int J Cancer 2002; 100: 249-260.
4. Chen KF, Li B, Wei YG, et al: Interleukin-10-819 promoter polymorphism associated with gastric cancer among Asians. J Int Med Res 2010; 38: 1-8.
5. Kimura K, Nagasaka T, Hoshizima N, et al: No duplicate KRAS mutation is identified on the same allele in gastric or colorectal cancer cells with multiple KRAS mutations. J Int Med Res 2007; 35: 450-457.
6. Black AR, Black JD, Azizkhan-Clifford J: Sp1 and Krüppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol 2001; 188: 143-160.
7. DiFeo A, Martignetti JA, Narla G: The role of KLF6 and its splice variants in cancer therapy. Drug Resist Updat 2009; 12: 1-7.
8. Guo H, Lin Y, Zhang H, et al: Tissue factor pathway inhibitor-2 was repressed by CpG hypermethylation through inhibition of KLF6 binding in highly invasive breast cancer cells. BMC Mol Biol 2007; 8: 110.
9. Narla G, Heath KE, Reeves HL, et al: KLF6, a candidate tumor suppressor gene mutated in prostate cancer. Science 2001; 294: 2563-2566.
10. Bieker JJ: Krüppel-like factors: three fingers in many pies. J Biol Chem 2001; 276: 34355-34358.
11. Liu J, Du T, Yuan Y, et al: KLF6 inhibits estrogen receptor-mediated cell growth in breast cancer via a c-Src-mediated pathway. Mol Cell Biochem 2010; 335: 29-35.
12. DiFeo A, Huang F, Sangodkar J, et al: KLF6-SV1 is a novel antiapoptotic protein that targets the BH3-only protein NOXA for degradation and whose inhibition extends survival in an ovarian cancer model. Cancer Res 2009; 69: 4733-4741.
13. Tahara E, Kadara H, Lacroix L, et al: Activation of protein kinase C by phorbol 12-myristate 13- acetate suppresses the growth of lung cancer cells through KLF6 induction. Cancer Biol Ther 2009; 8: 801-807.
14. Chen C, Hyytinen ER, Sun X, et al: Deletion, mutation, and loss of expression of KLF6 in human prostate cancer. Am J Pathol 2003; 162: 1349-1354.
15. Bar-Shira A, Matarasso N, Rosner S, et al: Mutation screening and association study of the candidate prostate cancer susceptibility genes MSR1, PTEN, and KLF6. Prostate 2006; 66: 1052-1060.
16. Seppälä EH, Autio V, Duggal P, et al: KLF6 IVS1 -27G>A variant and the risk of prostate cancer in Finland. Eur Urol 2007; 52: 1076-1081.
17. Kremertal S, Reeves HL, Narla G, et al: Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma. Hepatology 2004; 40: 1047-1052.
18. Cho YG, Kim CJ, Park CH, et al: Genetic alterations of the KLF6 gene in gastric cancer. Oncogene 2005; 24: 4588-4590.
19. Reeves HL, Narla G, Ogunbiyi O, et al: Kruppel- like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer. Gastroenterology 2004; 126: 1090-1103.
20. Sangodkar J, Shi J, DiFeo A, et al: Functional role of the KLF6 tumour suppressor gene in gastric cancer. Eur J Cancer 2009; 45: 666-676.
21. Miyaki M, Yamaguchi T, Iijima T, et al: Difference in the role of loss of heterozygosity at 10p15 (KLF6 locus) in colorectal carcinogenesis between sporadic and familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer patients. Oncology 2006; 71: 131-135.
22. Narla G, Friedman SL, Martignetti JA: Krüppel cripples prostate cancer: KLF6 progress and prospects. Am J Pathol 2003; 162: 1047-1052.
23. Spinola M, Leoni VP, Galvan A, et al: Genome-wide single nucleotide polymorphism analysis of lung cancer risk detects the KLF6 gene. Cancer Lett 2007; 251: 311-316.
24. Agell L, Hernández S, de Muga S, et al: KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations. Mod Pathol 2008; 21: 1470-1478.
25. DiFeo A, Narla G, Hirshfeld J, et al: Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination. Clin Cancer Res 2006; 12: 3730-3739.
26. Narla G, DiFeo A, Yao S, et al: Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread. Cancer Res 2005; 65: 5761-5768.
27. Narla G, DiFeo A, Reeves HL, et al: A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancerrisk. Cancer Res 2005; 65: 1213-1222.
28. Cho YG, Lee HS, Song JH, et al: KLF6 IVS1 -27G/A polymorphism with susceptibility to gastric cancers in Korean. Neoplasma 2008; 55: 47-50.
29. Raymond M, Rousset F: GENEPOP (version 1.2): population genetics software for exact tests and ecumenicism. J Hered 1995; 86: 248-249.
30. Wang S, Kang L, Chen X, et al: Frequent down- regulation and deletion of KLF6 in primary hepatocellular carcinoma. J Huazhong Univ Sci Technolog Med Sci 2010; 30: 470-476.
31. Pan XC, Chen Z, Chen F, et al: Inactivation of the tumor suppressor Krüppel-like factor 6(KLF6) by mutation or decreased expression in hepatocellular carcinomas. J Zhejiang Univ Sci B 2006; 7: 830-836.
32. Miele L, Beale G, Patman G, et al: The Kruppel- like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease. Gastroenterology 2008; 135: 282-291.e1.
33. Huang X, Li X, Guo B: KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3. J Biol Chem 2008; 283: 29795-29801.
34. Hartel M, Narla G, Wente MN, et al: Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer. Eur J Cancer 2008; 44: 1895-1903.
35. Narla G, DiFeo A, Fernandez Y, et al: KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis. J Clin Invest 2008; 118: 2711-2721.