KLF6 IVS1 -27G>A Variant and the Risk of Prostate Cancer in Finland

European Urology

Volumn 52, Issue 4, 2007, Pages 1076-1081

  Seppälä, Eija H ^a   Autio, Ville ^b   Duggal, Priya ^c   Ikonen, Tarja ^a   Stenman, Ulf Håkan ^d   Auvinen, Anssi ^e   Bailey Wilson, Joan E ^c   Tammela, Teuvo L J ^b,f   Schleutker, Johanna ^a  

^a UNIVERSITY OF TAMPERE   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^e Finnish Cancer Institute   (Finland)

^f TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

Association study; Benign prostate hyperplasia; Cancer susceptibility; KLF6; Prostate cancer

Indexed keywords

PROSTATE SPECIFIC ANTIGEN;

ADULT; AGED; ARTICLE; CANCER RISK; CANCER STAGING; CHROMOSOME VARIANT; CONTROLLED STUDY; FINLAND; GENE MUTATION; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENOTYPE; GLEASON SCORE; HUMAN; HUMAN CELL; KLF6 GENE; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; ONCOGENE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE HYPERTROPHY; RISK ASSESSMENT; RISK FACTOR;

ADENINE; FINLAND; GENOTYPE; GERM-LINE MUTATION; GUANINE; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; RISK FACTORS; TUMOR SUPPRESSOR PROTEINS; VARIATION (GENETICS);

EID: 34548238263     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2006.11.019     Document Type: Article

References (22)

1. Hsieh K., and Albertsen P.C. Populations at high risk for prostate cancer. Urol Clin North Am 30 (2003) 669-676
2. Aus G., Abbou C.C., Bolla M., et al. EAU guidelines on prostate cancer. Eur Urol 48 (2005) 546-551
3. Carter B.S., Bova G.S., Beaty T.H., et al. Hereditary prostate cancer: epidemiologic and clinical features. J Urol 150 (1993) 797-802
4. Schaid D.J. The complex genetic epidemiology of prostate cancer. Hum Mol Genet 13 spec no. 1 (2004) R103-R121
5. Narla G., Difeo A., Reeves H.L., et al. A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. Cancer Res 65 (2005) 1213-1222
6. Narla G., Heath K.E., Reeves H.L., et al. KLF6, a candidate tumor suppressor gene mutated in prostate cancer. Science 294 (2001) 2563-2566
7. Chen C., Hyytinen E.R., Sun X., et al. Deletion, mutation, and loss of expression of KLF6 in human prostate cancer. Am J Pathol 162 (2003) 1349-1354
8. Muhlbauer K.R., Grone H.J., Ernst T., et al. Analysis of human prostate cancers and cell lines for mutations in the TP53 and KLF6 tumour suppressor genes. Br J Cancer 89 (2003) 687-690
9. Reeves H.L., Narla G., Ogunbiyi O., et al. Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer. Gastroenterology 126 (2004) 1090-1103
10. Jeng Y.M., and Hsu H.C. KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas. Int J Cancer 105 (2003) 625-629
11. Kremer-Tal S., Reeves H.L., Narla G., et al. Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma. Hepatology 40 (2004) 1047-1052
12. Montanini L., Bissola L., and Finocchiaro G. KLF6 is not the major target of chromosome 10p losses in glioblastomas. Int J Cancer 111 (2004) 640-641
13. Koivisto P.A., Zhang X., Sallinen S.L., et al. Absence of KLF6 gene mutations in human astrocytic tumors and cell lines. Int J Cancer 111 (2004) 642-643
14. Kohler B., Wolter M., Blaschke B., et al. Absence of mutations in the putative tumor suppressor gene KLF6 in glioblastomas and meningiomas. Int J Cancer 111 (2004) 644-645
15. Boyault S., Herault A., Balabaud C., et al. Absence of KLF6 gene mutation in 71 hepatocellular carcinomas. Hepatology 41 (2005) 681-682
16. Bar-Shira A., Matarasso N., Rosner S., et al. Mutation screening and association study of the candidate prostate cancer susceptibility genes MSR1, PTEN, and KLF6. Prostate 66 (2006) 1052-1060
17. Schleutker J., Matikainen M., Smith J., et al. A genetic epidemiological study of hereditary prostate cancer (HPC) in Finland: frequent HPCX linkage in families with late-onset disease. Clin Cancer Res 6 (2000) 4810-4815
18. Maattanen L., Auvinen A., Stenman U.H., et al. European randomized study of prostate cancer screening: first-year results of the Finnish trial. Br J Cancer 79 (1999) 1210-1214
19. Makinen T., Tammela T.L., Stenman U.H., et al. Second round results of the Finnish population-based prostate cancer screening trial. Clin Cancer Res 10 (2004) 2231-2236
20. Dupont W.D., and Plummer Jr. W.D. Power and sample size calculations. A review and computer program. Control Clin Trials 11 (1990) 116-128
21. Koivisto P.A., Hyytinen E.R., Matikainen M., et al. Kruppel-like factor 6 germ-line mutations are infrequent in Finnish hereditary prostate cancer. J Urol 172 (2004) 506-507
22. Peltonen L., Palotie A., and Lange K. Use of population isolates for mapping complex traits. Nat Rev Genet 1 (2000) 182-190