Synthesis and evaluation of 5-substituted 9-hydroxypyrrolo[3,4-c]carbazole- 1,3(2H,6H)-diones as check point 1 kinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 22, 2010, Pages 7878-7889

  Sako, Yuki ^a   Ichikawa, Satoshi ^a   Osada, Akiko ^b   Matsuda, Akira ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Antitumor; Check point; Protein kinase; Structure based drug design

Indexed keywords

5 (3 CARBAMOYLBENZYLAMINOCARBONYL) 1,3 DIHYDROPYRROLO[3,4 C]CARBAZOLE 1,3(2H,6H) DIONE; 5 [3 [2 (GUANIDINO)ETHYLCARBAMOYL]BENZYLAMINOCARBONYL] 9 HYDROXY 1,3 DIHYDROPYRROLO[3,4 C]CARBAZOLE 1,3(2H,6H) DIONE; CARBAZOLE DERIVATIVE; CHECKPOINT KINASE 1; PROTEIN KINASE INHIBITOR; PYRROLE DERIVATIVE; UNC 01; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR DOCKING;

ANTINEOPLASTIC AGENTS; BINDING SITES; CARBAZOLES; CATALYTIC DOMAIN; CELL LINE, TUMOR; COMPUTER SIMULATION; HUMANS; PHTHALIMIDES; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78449265897     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.09.042     Document Type: Article

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