Structure-activity relationships of benzimidazole-based selective inhibitors of the mitogen activated kinase-5 signaling pathway

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 22, 2010, Pages 8054-8060

  Flaherty, Patrick T ^a   Chopra, Ishveen ^a   Jain, Prashi ^a   Monlish, Darlene ^a   Cavanaugh, Jane ^a  

^a DUQUESNE UNIVERSITY   (United States)

Author keywords

Benzimidazole; ERK; ERK5; Hoechst 33258; MEK; MEK5

Indexed keywords

1 ISOPROPYL 6 (3 METHOXYPROPOXY) 1H BENZO[D]IMIDAZOL 4 AMINE; BENZIMIDAZOLE; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

BENZIMIDAZOLES; EPIDERMAL GROWTH FACTOR; HEK293 CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 7; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78449256480     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.09.017     Document Type: Article

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