Anticonvulsant activity of 2,4(1H)-diarylimidazoles in mice and rats acute seizure models

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 22, 2010, Pages 7957-7965

  Zuliani, Valentina ^a   Fantini, Marco ^a   Nigam, Aradhya ^c   Stables, James P ^b   Patel, Manoj K ^c   Rivara, Mirko ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b Stroke (JPS) ASP Program   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Epilepsy; hNaV1.2; Seizure models; Sodium channel blockers

Indexed keywords

2,4(1H) DIARYLIMIDAZOLE DERIVATIVE; BIA 2 93; BW 534U87; CARBAMAZEPINE; CARBAMIC ACID 2 (2 CHLOROPHENYL) 2 HYDROXYETHYL ESTER; ESLICARBAZEPINE ACETATE; JZP 4; LAMOTRIGINE; LICARBAZEPINE; OXCARBAZEPINE; PHENYTOIN; RUFINAMIDE; SAFINAMIDE; SODIUM CHANNEL BLOCKING AGENT; SODIUM CHANNEL NAV1.2; TOPIRAMATE; UNCLASSIFIED DRUG; ZONISAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; ATAXIA; DOSE RESPONSE; DRUG STRUCTURE; MALE; MOUSE; NONHUMAN; RAT; SEDATION; SEIZURE; SODIUM CURRENT;

ADMINISTRATION, ORAL; ANIMALS; ANTICONVULSANTS; CELL LINE; DISEASE MODELS, ANIMAL; HUMANS; IMIDAZOLES; MICE; MOTOR ACTIVITY; RATS; SEIZURES; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS; RATTUS; RODENTIA;

EID: 78449246529     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.09.029     Document Type: Article

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