Berberine moderates glucose and lipid metabolism through multipathway mechanism

Evidence-based Complementary and Alternative Medicine

Volumn 2011, Issue , 2011, Pages

  Xiao, Xinhua ^a   Zhang, Qian ^a   Feng, Kai ^a   Wang, Tong ^a   Li, Wenhui ^a   Yuan, Tao ^a   Sun, Xiaofang ^a   Sun, Qi ^a   Xiang, Hongding ^a   Wang, Heng ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BERBERINE; CCAAT ENHANCER BINDING PROTEIN; CHOLESTEROL; GLUCOSE; GLUCOSE TRANSPORTER 4; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MITOGEN ACTIVATED PROTEIN KINASE 14; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; RESISTIN; STRESS ACTIVATED PROTEIN KINASE 1; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION PROFILING; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION;

EID: 78349291585     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2011/924851     Document Type: Article

References (50)

1. O'Brien R. M., Granner D. K., Regulation of gene expression by insulin Physiological Reviews 1996 76 4 1109 1161
2. Kiberstis P. A., A surfeit of suspects Science 2005 307 5708 369
3. Ni Y. X., Therapeutic effect of berberine on 60 patients with type II diabetes mellitus and experimental research Zhong Xi Yi Jie He Za Zhi 1988 8 12 711 707
4. Yin J., Xing H., Ye J., Efficacy of berberine in patients with type 2 diabetes mellitus Metabolism 2008 57 5 712 717
5. Cicero A. F. G., Rovati L. C., Setnikar I., Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents: a single-blind clinical investigation Arzneimittel-Forschung 2007 57 1 26 30
6. Lee B., Yang C. H., Hahm D.-H., Choe E. S., Lee H.-J., Pyun K.-H., Shim I., Inhibitory effects of Coptidis rhizoma and berberine on cocaine-induced sensitization Evidence-Based Complementary and Alternative Medicine 2009 6 1 85 90
7. Zhou L., Yang Y., Wang X., Liu S., Shang W., Yuan G., Li F., Tang J., Chen M., Chen J., Berberine stimulates glucose transport through a mechanism distinct from insulin Metabolism 2007 56 3 405 412
8. Yin J., Gao Z., Liu D., Liu Z., Ye J., Berberine improves glucose metabolism through induction of glycolysis American Journal of Physiology 2008 294 1 E148 E156
9. Turner N., Li J.-Y., Gosby A., To S. W. C., Cheng Z., Miyoshi H., Taketo M. M., Cooney G. J., Kraegen E. W., James D. E., Hu L.-H., Li J., Ye J.-M., Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate amp-activated protein kinase and improve insulin action Diabetes 2008 57 5 1414 1418
10. Lee Y. S., Kim W. S., Kim K. H., Yoon M. J., Cho H. J., Shen Y., Ye J.-M., Lee C. H., Oh W. K., Kim C. T., Hohnen-Behrens C., Gosby A., Kraegen E. W., James D. E., Kim J. B., Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states Diabetes 2006 55 8 2256 2264
11. Lee S., Lim H.-J., Park J.-H., Lee K.-S., Jang Y., Park H.-Y., Berberine-induced LDLR up-regulation involves JNK pathway Biochemical and Biophysical Research Communications 2007 362 4 853 857
12. Smith A. G., Muscat G. E. O., Skeletal muscle and nuclear hormone receptors: implications for cardiovascular and metabolic disease International Journal of Biochemistry and Cell Biology 2005 37 10 2047 2063
13. Chavan P., Joshi K., Patwardhan B., DNA microarrays in herbal drug research Evidence-Based Complementary and Alternative Medicine 2006 3 4 447 457
14. Livak K. J., Schmittgen T. D., Analysis of relative gene expression data using real-time quantitative PCR and the 2-CT method Methods 2001 25 4 402 408
15. Yin J., Hu R., Chen M., Tang J., Li F., Yang Y., Chen J., Effects of berberine on glucose metabolism in vitro Metabolism 2002 51 11 1439 1443
16. Tang L.-Q., Wei W., Chen L.-M., Liu S., Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats Journal of Ethnopharmacology 2006 108 1 109 115
17. Gao C. R., Zhang J. Q., Huang Q. L., Experimental study on berberin raised insulin sensitivity in insulin resistance rat models Zhongguo Zhong Xi Yi Jie He Za Zhi 1997 17 3 162 164
18. Brusq J.-M., Ancellin N., Grondin P., Guillard R., Martin S., Saintillan Y., Issandou M., Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine Journal of Lipid Research 2006 47 6 1281 1288
19. Kong W., Wei J., Abidi P., Lin M., Inaba S., Li C., Wang Y., Wang Z., Si S., Pan H., Wang S., Wu J., Wang Y., Li Z., Liu J., Jiang J.-D., Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins Nature Medicine 2004 10 12 1344 1351
20. Shepherd P. R., Withers D. J., Siddle K., Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling Biochemical Journal 1998 333 3 471 490
21. Cheng Z., Pang T., Gu M., Gao A.-H., Xie C.-M., Li J.-Y., Nan F.-J., Li J., Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK Biochimica et Biophysica Acta 2006 1760 11 1682 1689
22. Kim S. H., Shin E.-J., Kim E.-D., Bayaraa T., Frost S. C., Hyun C.-K., Berberine activates GLUT1-mediated glucose uptake in 3T3-L1 adipocytes Biological and Pharmaceutical Bulletin 2007 30 11 2120 2125
23. Gao Z., Hwang D., Bataille F., Lefevre M., York D., Quon M. J., Ye J., Serine phosphorylation of insulin receptor substrate 1 by inhibitor B kinase complex Journal of Biological Chemistry 2002 277 50 48115 48121
24. Calera M. R., Vallega G., Pilch P. F., Dynamics of protein-tyrosine phosphatases in rat adipocytes Journal of Biological Chemistry 2000 275 9 6308 6312
25. Goldstein B. J., Bittner-Kowalczyk A., White M. F., Harbeck M., Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the GRB2 adaptor protein Journal of Biological Chemistry 2000 275 6 4283 4289
26. Bento J. L., Palmer N. D., Mychaleckyj J. C., Lange L. A., Langefeld C. D., Rich S. S., Freedman B. I., Bowden D. W., Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes Diabetes 2004 53 11 3007 3012
27. Kipfer-Coudreau S., Eberl D., Sahbatou M., Bonhomme A., Guy-Grand B., Froguel P., Galan P., Basdevant A., Clment K., Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects Diabetologia 2004 47 7 1278 1284
28. Di Paola R., Frittitta L., Miscio G., Bozzali M., Baratta R., Centra M., Spampinato D., Santagati M. G., Ercolino T., Cisternino C., Soccio T., Mastroianno S., Tassi V., Almgren P., Pizzuti A., Vigneri R., Trischitta V., A variation in 3′ utr of hptp1b increases specific gene expression and associates with insulin resistance American Journal of Human Genetics 2002 70 3 806 812
29. Zabolotny J. M., Haj F. G., Kim Y.-B., Kim H.-J., Shulman G. I., Kim J. K., Neel B. G., Kahn B. B., Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action Journal of Biological Chemistry 2004 279 23 24844 24851
30. Somwar R., Kim D. Y., Sweeney G., Huang C., Niu W., Lador C., Ramlal T., Klip A., GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinase Biochemical Journal 2001 359 3 639 649 (Pubitemid 33063389)
31. Xi X., Han J., Zhang J.-Z., Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase Journal of Biological Chemistry 2001 276 44 41029 41034
32. Konrad D., Somwar R., Sweeney G., Yaworsky K., Hayashi M., Ramlal T., Klip A., The antihyperglycemic drug -lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation Diabetes 2001 50 6 1464 1471 (Pubitemid 32500181)
33. Zhou G., Myers R., Li Y., Chen Y., Shen X., Fenyk-Melody J., Wu M., Ventre J., Doebber T., Fujii N., Musi N., Hirshman M. F., Goodyear L. J., Moller D. E., Role of AMP-activated protein kinase in mechanism of metformin action Journal of Clinical Investigation 2001 108 8 1167 1174
34. Ko B.-S., Choi S. B., Park S. K., Jang J. S., Kim Y. E., Park S., Insulin sensitizing and insulinotropic action of berberine from Cortidis Rhizoma Biological and Pharmaceutical Bulletin 2005 28 8 1431 1437
35. Hsu J. H., Wu J. C., Liou S. S., Liu I. M., Huang L. W., Cheng J. T., Mediation of endogenous -endorphin by tetrandrine to lower plasma glucose in streptozotocin-induced diabetic rats Evidence-Based Complementary and Alternative Medicine 2004 1 2 193 201
36. Rosen E. D., MacDougald O. A., Adipocyte differentiation from the inside out Nature Reviews Molecular Cell Biology 2006 7 12 885 896
37. Yoon J. C., Puigserver P., Chen G., Donovan J., Wu Z., Rhee J., Adelmant G., Stafford J., Kahn C. R., Granner D. K., Newgard C. B., Spiegelman B. M., Control of hepatic gluconeogenesis through the transcriptional coaotivator PGC-1 Nature 2001 413 6852 131 138 (Pubitemid 32867868)
38. Herzig S., Long F., Jhala U. S., Hedrick S., Quinn R., Bauer A., Rudolph D., Schutz G., Yoon C., Puigserver P., Spiegelman B., Montminy M., CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 Nature 2001 413 6852 179 183 (Pubitemid 32867880)
39. Spiegelman B. M., PPAR- : adipogenic regulator and thiazolidinedione receptor Diabetes 1998 47 4 507 514
40. Martens F. M. A. C., Visseren F. L. J., Lemay J., De Koning E. J. P., Rabelink T. J., Metabolic and additional vascular effects of thiazolidinediones Drugs 2002 62 10 1463 1480
41. Huang C., Zhang Y., Gong Z., Sheng X., Li Z., Zhang W., Qin Y., Berberine inhibits 3T3-L1 adipocyte differentiation through the PPAR pathway Biochemical and Biophysical Research Communications 2006 348 2 571 578
42. Zhou L. B., Chen M. D., Wang X., Song H. D., Yang Y., Tang J. F., Li F. Y., Xu M. Y., Chen J. L., Effect of berberine on the differentiation of adipocyte Zhonghua Yi Xue Za Zhi 2003 83 4 338 340
43. Zhou J. Y., Zhou S. W., Zhang K. B., Tang J. L., Guang L. X., Ying Y., Xu Y., Zhang L., Li D. D., Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats Biological and Pharmaceutical Bulletin 2008 31 6 1169 1176
44. Zhou J. Y., Zhou S. W., Effect of berberine on glucolipid metabolization in diabetic skeletal muscle and its mechanism Journal of Chinese Pharmaceutical Sciences 2007 16 4 300 306
45. Duval C., Mller M., Kersten S., PPAR and dyslipidemia Biochimica et Biophysica Acta 2007 1771 8 961 971
46. Doggrell S. A., Berberinea novel approach to cholesterol lowering Expert Opinion on Investigational Drugs 2005 14 5 683 685
47. Fleury C., Neverova M., Collins S., Raimbault S., Champigny O., Levi-Meyrueis C., Bouillaud F., Seldin M. F., Surwit R. S., Ricquier D., Warden C. H., Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia Nature Genetics 1997 15 3 269 272
48. Ding L. B., Lu F. E., Ye A. L., Xu L., Wang K., Effects of huanglian jiedu decoction on leptin and resistin in insulin resistive rats Zhongguo Zhong Xi Yi Jie He Za Zhi 2006 26 3 232 235
49. Love-Gregory L., Permutt M. A., HNF4A genetic variants: role in diabetes Current Opinion in Clinical Nutrition and Metabolic Care 2007 10 4 397 402
50. Gao Z., Leng S., Lu F., Xie M., Xu L., Wang K., Effect of berberine on expression of hepatocyte nuclear factor-4 in rats with fructose-induced insulin resistance Journal of Huazhong University of Science and TechnologyMedical Science 2008 28 3 261 265