An industrial insight into pellet manufacture by extrusion spheronization

Drug Delivery Technology

Volumn 10, Issue 6, 2010, Pages 50-54

  McConnell, Emma L ^a   Pygall, Samuel R ^a   Ward, Rob ^c   Seiler, Christian ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Global Controlled Release Centre of Excellence   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BARIUM SULFATE; CHITOSAN; CREMOPHOR; DIMETHYL SULFOXIDE; EXCIPIENT; GLYCEROL STEARATE; IBUPROFEN; LACTOSE; MACROGOL; MANNITOL; MICROCRYSTALLINE CELLULOSE; POLYSORBATE 80; POVIDONE; RANITIDINE; SORBITAN; STARCH;

DESICCATION; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG GRANULATION; DRUG INDUSTRY; DRUG MANUFACTURE; DRUG PELLET; DRUG RELEASE; DRUG SOLUBILITY; EMULSION; MOISTURE; PELLET EXTRUSION; POROSITY; PRACTICE GUIDELINE; QUALITY CONTROL; REVIEW; SLOW DRUG RELEASE; SPHERONIZATION;

EID: 78349261209     PISSN: 15372898     EISSN: 1944818X     Source Type: Trade Journal    
DOI: None     Document Type: Review

References (18)

1. MacRitchie KA, Newton JM, Rowe RC. The evaluation of the rheological properties of lactose/microcrystalline cellulose and water mixtures by controlled stress rheometry and the relationship to the production of spherical pellets by extrusion/spheronization. Eur J Pharm Sci. 2002;17:42-50
2. Neuton JM. Extrusion and extruders. In. J, Swarbrick J, Boylan J, eds. Encyclopedia of Pharmaceutical Technology Marcel Dckker Inc: New York, NY, and Basel, Switzerland;2002:1220-1236
3. Ek R, Newton JM. Microcrystalline cellulose as a sponge as an alternative concept to the crystalline-gel model for extrusion and spheronisation. Pharm Res. 1998;15(4):509-512
4. Dukic-Ott A, Remon JP, Foreman P, Vervact C. Immediate release of poorly soluble drugs from starch based pellets prepared via extrusion/spheronisation. Eur J Pharm Biopharm. 2007;67(3):715-724
5. Jess K, Steckel H. The extrusion and spheronisation of chitosan. Pharm Technol Eur. 2007;7:21-30
6. Liew CV, Gu L, Soh JLP, Heng PWS. Functionality of cross-linked polyvinylpyrrolidone as a spheronization aid a promising alternative to microcrystalline cellulose. Pharm Res. 2005;22:1387-1398
7. Howard MA, Neau SH, Jack JS. PEO and MPEG in high drug load extruded and spheronised beads that are devoid of MCC. Int J Pharm. 2006;307:66-76
8. Basil AW, Newton JM, Lacey LF. Formulation of ranitidine pellets by extrusion spheronisation with little or no microcrystalline cellulose. Pharm Dev Technol. 1999;4(4):499-505
9. Millili GP, Wignent RJ, Schwartz JB. The strength of microcrystalline cellulose pellets the effect of granulating with water/ethanol mixtures. Drug Dev Ind Pharm. 1990;16:1411-1426
10. Schroder M, Klemebudde P. Structure of disintegrating pellets with regard to fractal geometry. Pharm Res. 1995;12:1694-1700
11. Mascia S. Rheology and Processing of Pharmaceutical Pastes Thesis University of Birmingham;2008
12. Sinha VR, Agrawal MK, Kumna R, Blunge JR. Influence of operational variables on properties of piroxicam pellets prepared by extrusion- spheronization a technical note. AAPS PharmSciTech. 2007;8(1) Article 20.
13. Podczeck F, Alessi P, Newton JM. The preparation of pellet containing non-ionic surfactants by extrusion/spheronization. Int J Pharm. 2008;361(1-2):33-49
14. O'Connor RE, Schwartz JB. Spheronization part 2 drug release from drug-diluent mixtures. Drug Dev Ind Pharm. 1984;11:1837-1857
15. Serratoni M, Newton JM, Booth S, Clarke A. Controlled drug release from pellets containing water-insoluble drugs dissolved in a self-emulsifying system. Eur J Pharm Biopharm. 2007;65(1):94-98.
16. Tuleu C, Newton JM, Rose J, Euler D, Saklatvala R, Clarke A, Booth SW. Comparative bioavailability study in dogs of a self-emulsifying formulation of progesterone presented in a pellet and liquid form compared with an aqueous suspension of progesterone. J Pharm Sci. 2004;93(6):1495-1502.
17. Vervaet C, Baert L, Remon JP. Enhancement of in vitro drug release by using polyethylene glycol 400 and PEG-40 hydrogenated castor oil in pellets made by extrusion/spheronization. Int J Pharm. 1994;108(3):207-212
18. Podezeck F, Maghetti A, Newton JM. The influence of non-ionic surfactants on the rheological properties of drug/microcrystalline cellulose/water mixtures and their use in the preparation and drug release performance of pellets prepared by extrusion/spheronization. Eur J Pharm Sci. 2009;37(3-4):334-340