Reflections on the origins and evolution of genetic toxicology and the environmental mutagen society

Environmental and Molecular Mutagenesis

Volumn 51, Issue 8-9, 2010, Pages 746-760

  Wassom, John S ^a   Malling, Heinrich V ^b   Sankaranarayanan, K ^c   Lu, Po Yung ^a  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Chemical mutagenesis; Environmental Mutagen Society; History of genetic toxicology; Mutation research

Indexed keywords

CHEMICAL MUTAGEN; COPPER OXIDE; ENVIRONMENTAL MUTAGEN; OXIDIZING AGENT; PERMANGANATE POTASSIUM; POTASSIUM CHLORATE; POTASSIUM CHROMATE; UNCLASSIFIED DRUG; ZINC SULFATE; MUTAGENIC AGENT;

ARTICLE; ASPERGILLUS NIGER; BACILLUS PRODIGIOUS; BACTERIUM; DROSOPHILA; ENVIRONMENTAL MUTAGEN SOCIETY; EUROPE; GENETIC RISK; GENETIC TOXICOLOGY; GENETICS; GERM CELL; HEALTH CARE ORGANIZATION; HISTORY; HUMAN; IONIZING RADIATION; MOLECULAR BIOLOGY; MUTAGENESIS; MUTATIONAL ANALYSIS; PUBLIC HEALTH; RADIATION EXPOSURE; RADIATION PROTECTION; RISK ASSESSMENT; UNITED STATES; X RAY; ENVIRONMENT;

ENVIRONMENT; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; MOLECULAR BIOLOGY; MUTAGENS; SOCIETIES, SCIENTIFIC;

EID: 78349260405     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20589     Document Type: Article

References (98)

1. Ames BN, Gold LS. 1990. Too many rodent carcinogens: Mitogenesis increases mutagenesis. Science 249: 970-971.
2. Ames BN, Durston WE, Yamasaki E, Le FD. 1973. Carcinogens are mutagens: A simple test system for combining liver homogenates for activation and bacteria for detection. Proc Natl Acad Sci USA 70: 2281-2285.
3. Ashby J, Patton D. 1993. The influence of chemical structure on the extent and sites of carcinogenesis of 522 rodent carcinogens and 55 different human carcinogen exposures. Mutat Res 286: 3-74.
4. Ashby J, Tennant RW. 1988. Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the US NCI/NTP. Mutat Res 204: 17-115.
5. Ashby J, Tennant RW. 1991. Definitive relationships among chemical structure, carcinogenicity, and mutagenicity for 301 chemicals tested by the US NTP. Mutat Res 257: 229-308.
6. Ashby J, Waters MD, Preston J, Adler ID, Douglas GR, Fielder R, Shelby MD, Anderson D, Sofuni T, Gopalan HNB, Becking G, Sonich-Mullin C. 1996. IPCS harmonization of methods for the prediction and quantification of human carcinogenic/mutagenic hazard, and for indicating the probable mechanism of action of carcinogens. Mutat Res 352: 153-157.
7. Auerbach C. 1960. Chemical mutagenesis in animals. Abh Deutsch Akad Wiss Berlin Klin Med 1: 1-13.
8. Auerbach C. 1976. Mutation Research. London: Chapman and Hall, 504 p.
9. Auerbach C, Robson JM. 1947. The production of mutations by chemical substances. Proc R Soc Edinburgh Section B 62: 271-283.
10. Auerbach C, Robson JM, Cam JG. 1947. The chemical production of mutations. Science 105: 243-247.
11. Barratt MD, Rodford R. 2001. The computational prediction of toxicity. Curr Opin Chem Biol 5: 383-388.
12. Barthelmess A. 1956. Mutagenic drugs. Arzneim Forsch 6: 157-168.
13. BEIR. 2005. Biological Effects of Ionizing Radiation Committee of the National Academy of Sciences-National Research Council. Health Risks From Exposure to Low Levels of Ionizing Radiation (BEIR VII, Phase 2 report). Washington, DC: Natl Acad Press. 424 p.
14. Brusick D. 1980. Principles of Genetic Toxicology. New York: Plenum Press. 279 p.
15. Brusick D. 1994. Personal thoughts on the future of the Environ Mutagen Society. Environ Mol Mutagen 23( Suppl 24): 15-17.
16. Brusick D. 1995. Applications for transgenic animals in toxicology. Arch Toxicol Suppl 17: 23-34.
17. Collins FS, Gray GM, Bucher JR. 2008. Transforming environmental health protection. Science 319: 906-907.
18. Correns C. 1900. Mendels regel über das verhalten der nachkommenschaft der rassenbastarde. Ber Deutsch Bot Ges 18: 158-168.
19. Correns C. 1950. Mendel's law concerning the behavior of progeny of varietal hybrids. Genetics 35: 33-41.
20. Crow JF. 1968. Chemical risk to future generations. Sci Citizen 10, 113-117.
21. Crow JF. 1989. Fortunes of war. Genetics 122: 467-469.
22. De Vries H. 1900a. Das spaltungsgesetz der bastarde.Vorlaufige mitteilung. Ber Deutsch Bot Ges 18: 83-90.
23. De Vries H. 1900b. Sur la loi de disjunction des hybrids. Comp R l'Acad Sci 130: 845-847.
24. De Vries H. 1901-1903. Die mutationstheorie. Leipzig: Verlag von Veit and Comp. Bd. 1 (1901). 784 p. Bd. 2 (1903). 684 p.
25. De Vries H. 1910. The Mutation Theory. Chicago: The Open Court Publishing Co. Vol. 1, 582 p. Vol.2, 683 p.
26. De Vries H. 1950. Concerning the law of segregation of hybrids. Genetics 35: 30-32 (English translation of De Vries 1900b).
27. DHEW Subcommitee on Environ Mutagen. 1977. Approaches to Determining the Mutagenic Properties of Chemicals: Risk to Future Generations. Committee to Coordinate Toxicology and Related Programs. Washington, DC: US Department of Health and Welfare (DHEW). 58 p.
28. DNHW/DOE. 1988. Department of National Health and Welfare Health Protection Branch (DNHW) / Department of Energy (DOE) Environmental Contaminants Advisory committee on Mutagenesis. Environ Mol Mutagen 11: 261-304.
29. Drake JW. 1994. Looking backward on a century of mutation research. Environ Mol Mutagen 23( Suppl 24): 11-14.
30. EPA. 2009. The US Environmental Protection Agency's Strategic Plan for Evaluating the Toxicity of Chemicals. Washington: DCEPA/100/K-09/00. Available at
31. Frickel S. 2001. The Environ Mutagen Society and the emergence of genetic toxicology: A sociological perspective. Mutat Res 488: 1-8.
32. Frickel S. 2004. Chemical Consequences: Environmental Mutagens, Scientist Activism, and the Rise of Genetic Toxiocology. New Brunswick NJ: Rutgers University Press. 224 p.
33. Gaulden ME, Jagger J, White V. 2007. Personal reflections on the life and legacy of Alexander Hollaender. Mutat Res 635: 1-16.
34. Goldstein A. 1962. Mutagens currently of potential significance to man and other species. In: Shull WJ, editor. Mutations. Ann Arbor: University of Michigan Press. pp 167-242.
35. Hartung T. 2009. Toxicology for the twenty-first century. Nature 460: 208-212.
36. Hartung T, Rovida C. 2009. Chemical regulators have overreached. Nature 460: 1080-1081.
37. He L, Jurs PC, Custer LL, Durham SK, Pearl GM. 2003. Predicting the genotoxicity of polycyclic aromatic compounds from molecular structure with different classifiers. Chem Res Toxicol 16: 1567-1580.
38. Hoffmann GR. 2004. History of environmental and molecular mutagenesis. Environ Mol Mutagen 44: 352-362.
39. Hollaender A, editor. 1954. Radiation Biology (High Energy Radiation), Vol. 1-3. New York: McGraw Hill. 1200 p.
40. Hollaender A, de Serres FJ, editors. 1978. Toxic Substances Control Act. In: Chemical Mutagens: Principles and Methods for Their Detection, Vol. 5. New York: Plenum Press. pp 287-335.
41. ICRP. 1977. Recommendations of the International Commission on Radiological Protection (adopted January 17, 1977). ICRP Publication 26. Oxford: Pergamon Press. Annals of the ICRP. pp 1-3.
42. ICRP. 2007. Recommendations of the International Commission on Radiological Protection (approved by the Commission in March 2007). Amsterdam: Elsevier. ICRP Publication 103. 332 p.
43. Kirkland DJ. 1993. Genetic toxicology testing requirements: Official and unofficial views from Europe. Environ Mol Mutagen 21: 8-14.
44. Knight AW, Little S, Houck K, Dix D, Judson R, Richard A, McCarroll N, Akerman G, Yang C, Birrell L, Walmsle RM. 2009. Evaluation of high-throughput genotoxicity assays used in profiling the US ToxCast chemicals. Reg Toxicol Pharm 55: 188-199.
45. Lederberg J. 1997. Some early stirrings (1950 ff.) of concern about environmentalmutagens. Environ Mol Mutagen 30: 3-10.
46. Legator MS. 1994. Genetic toxicology: Lessons from the past, directions for the future. Environ Mol Mutagen 23( Suppl 24): 3-6.
47. Lohman PHM. 2002. International Commission for the Protection of the Environment Against Mutagens and Carcinogens: A historical perspective. Mutat Res 511: 63-71.
48. MacGregor JT. 1994. Environmental mutagenesis: Past and future directions. Mutat Res 23: 73-77.
49. MacGregor JT. 1998. Transgenic animal models for mutagenesis studies: Role in mutagenesis research and regulatory testing. Environ Mol Mutagen 32: 106-109.
50. MacGregor JT, Casciano D, Muller L. 2000. Strategies and testing methods for identifying mutagenic risks. Mutat Res 455: 3-20.
51. Malling HV. 1966. Mutagenicity of two potent carcinogens, dimethylnitrosamin and diethylnitrosamine, in Neurospora crassa. Mutat Res 3: 537-540.
52. Malling HV. 2004. History of the science of mutagenesis from a personal perspective. Environ Mol Mutagen 44: 372-386.
53. McCann J, Choi E, Yamasaki E, Ames BN. 1975. Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals. Proc Natl Acad Sci USA 72: 5135-5139.
54. Mendel G. 1866. Versuche über Pflanzenhybriden. Vern des Naturf Vereines in Bwnn. 4 1886. (English translation revision published in J R Horticulture Soc 26: 1-32.)
55. Mosier PD, Jurs PC, Custer LL, Durham SK, Pearl GM. 2003. Predicting the genotoxicity of thiophene derivatives from molecular structure. Chem Res Toxicol 16: 721-732.
56. Muller HJ. 1927. Artificial transmutation of the gene. Science 64: 84-87.
57. Muller HJ. 1928. The measurement of gene mutation rate in Drosophila, its high variability, and its dependence upon temperature. Genetics 13: 279-357.
58. Muller HJ. 1934. Radiation genetics. In Proceedings of 4th International Congress on Radiology. 2: l-102.
59. NRC National Research Council. 1983. Identifying and estimating the genetic impact of chemical mutagens. Committee on Chemical Environmental Mutagens, Board of Toxicology and Environmental Hazards, Commission of Life Sciences. Washington DC: National Academy Press. 295 p.
60. NRC. 2007. Committee on Toxicity Testing and Assessment of Environmental Agents, Board of Environmental Studies and Toxicology, Institute for Laboratory Animal Research, National Research Council of the National Academies. Washington DC: The National Academies Press. 216 p.
61. st Century: A roadmap for the future. National Toxicity Program. National Institute of Environmental Health Sciences. Research Triangle Park, NC. Available at: and
62. Papa E, Pilutti P, Gramatica P. 2008. Prediction of PAH mutagenicity in human cells by QSAR classification. Environ Res 19: 115-127.
63. Piotrowski PL, Sumpter BG, Malling HV, Wassom JS, Lu PY, Brothers RA, Sega GA, Martin SA, Parang M. 2007. A toxicity evaluation and predictive system based on neural networks and wavelets. JChem Info Model 47: 676-685.
64. Preston RJ. 1989. A short journey from classical to molecular cytogenetics. Environ Mol Mutagen 14: 126-132.
65. Purves D, Harvey C, Tweats D, Lumley CE. 1995. Genotoxicity testing: Current practices and strategies used by the pharmaceutical industry. Mutagen 10: 297-312.
66. Rapoport IA. 1946. Carbonyl compounds and the chemical mechanism of mutations. C R Dokl Acad Sci URSS 54: 65-67.
67. Rapoport IA. 1948. Effects of ethylene oxide, glycidol, and glycols on gene mutations. Dokl Akad Nauk SSSR 60: 469-472.
68. Regaud C, Dubrenil G. 1908. Perturbations dans le developpement des oeufs fecondes par des spermatozoides roentgenises chez le lapin. Compt Rend Soc Biol 64: 1014-1016.
69. Rothfuss A, Steger-Hartmann T, Heinrich N, Wichard J. 2006. Computational prediction of the chromosome-damaging potential of chemicals. Chem Res Toxicol 19: 1313-1319.
70. Russell WL. 1954. Genetic effects of radiation in mammals. In: Hollaender A, editor. Radiation Biology, Vol. 1, Part 2. High Energy Radiation. New York: McGraw Hill. pp 825-859.
71. Sankaranarayanan K, Chakraborty R. 2000. Ionizing radiation and genetic risks. XIII. Summary and synthesis of papers VI to XII, estimates of genetic risks in the year 2000. Mutat Res 453: 183-197.
72. Sankaranarayanan K, Wassom JS. 2005. Ionizing radiation and genetic risks. XIV. Potential research directions in the post-genome era based on knowledge of repair of radiation-induced DNA double-strand breaks in mammalian somatic cells and the origin of deletions associated with human genomic disorders. Mutat Res 578: 333.
73. Sankaranarayanan K, Wassom JS. 2008. Reflections on the impact of advances in the assessment of risks of exposure to ionizing radiation on international radiation protection recommendations between the mid-1950s and the present. Mutat Res 658: 1-27.
74. Schiemann E. 1912. Mutations in Aspergillus niger van Tieghem. Z In-dukt Abstamm Vererbungsl 8: 1-35.
75. Schmidt CW. 2009. TOX21 new dimensions of toxicity testing. Environ Health Perspect 117: A349-A353.
76. Schwarman MR, Wilson MP. 2009. New science for chemical policy. Science 326: 1065-1066.
77. Service RF. 2009. A new wave of chemical regulations just ahead? Science 325: 692-693.
78. Setlow RB. 1987. In memoriam. Alexander Hollaender 1898-1986. Environ Mutagen 9: 107-109.
79. Shelby MD, Sofuni T. 1991. Toxicology testing requirements and the US-Japan collaborative study on in vitro tests for chromosome aberrations. Environ Health Perspect 94: 255-259.
80. Sheldon LS, Hubal EAC. 2009. Exposure as part of a systems approach for assessing risks. Environ Health Perspect 117: 1181-1184.
81. Shirasu Y. 1988. The Japanese mutagenicity studies guidelines for pesticide registration. Mutat Res 205: 393-395.
82. Sobels FH. 1977. The founding of the International Commission for Protection against Environmental Mutagens and Carcinogens (ICPEMC). In: Scott D, Bridges BA, editors. Progress in genetic toxicology: Proc. II Int. Conf. Environmental Mutagens, Edinburgh, July 11-15, 1977. Amsterdam: Elsevier/North-Holland. pp 117-121.
83. Stokstad E. 2009. Putting chemicals on a path to better risk assessment. Science 325: 694-695.
84. Tschermak-Sysenegg E. 1900. Concerning artificial crossing in Pisum sativum. Ber Deutsch Bot Ges 18: 232-239.
85. UNSCEAR. 2001. Hereditary Effects of Radiation. United Nations Scientific Committee on the Effects of Atomic Radiation Report to the General Assembly with Scientific Annex. New York: United Nations. UN Publication Sales No. E. 01.IX. 2.
86. US Food and Drug Administration. 1982. Toxicological Principles for the Safety Assessment of Direct Food Additives and Color Additives Used in the United States. Washington DC: US Food and Drug Administration. pp 1-130.
87. US Food and Drug Administration. 1993. Draft Toxicological Principles for the Safety Assessment of Direct Food Additives and Color Additives Used in Food ("Redbook II"). Washington DC: US Food and Drug Administration. 109 p. Available at:
88. Von Borstel RC, Steinberg CM. 1996. Alexander Hollaender: Myth or mensch. Genetics 143: 1051-1056.
89. Votano JR, Parham M, Hall LH, Kier LB, Oloff S, Tropsha A, Xie Q, Tong W. 2004. Three new consensus QSAR models for the prediction of Ames genotoxicity. Mutagen 19: 365-377.
90. Wassom JS. 1980. Mutagenicity research in the United States. Mutagens Toxicol 9: 4-15.
91. Wassom JS. 1989. The origins of genetic toxicology and the Environmental Mutagen Society. Environ Mol Mutagen 14( Suppl 16): 1-6.
92. Wassom JS, Von Halle ES. 1991. Mutation research and the literature of genetic toxicology: Another milestone. Mutat Res 250: 499-502.
93. Waters MD, Auletta A. 1981. The GEN-TOX program: Genetic activity evaluation. J Chem Inf Comput Sci 21: 35-38.
94. Wilson C, de Serres FJ. 1987. Alexander Hollaender 1898-1986. Mutat Res 179: 1-3.
95. Wolff F. 1909. Ueber Modifikationen und experimentelle ausgeloste mutatioen von Bacillus prodigiosus und anderen Schizophytes. Zeitsch Ind Abstammungelehre 2: 90-132.
96. Zeiger E. 2004. History and rationale of genetic toxicity testing: An impersonal and sometimes a personal view. Environ Mol Mutagen 44: 363-371.
97. Zeiger E, Haseman JK, Shelby MD, Margolin BH, Tennant RW. 1990. Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: Confirmation of earlier results with 41 additional chemicals. Environ Mol Mutagen 16( Suppl 18): 1-14.
98. Zhu H, Ye L, Richard A, Golbraikh A, Wright FA, Rusyn I, Tropsha A. 2009. A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents. Environ Health Perspect 117: 1257-1264.