Investigation of the toxic functional group of cephalosporins by zebrafish embryo toxicity test

Archiv der Pharmazie

Volumn 343, Issue 10, 2010, Pages 553-560

  Zhang, Jingpu ^b   Meng, Jie ^b   Li, Yaping ^a   Hu, Changqin ^a  

^a NATIONAL INSTITUTE FOR THE CONTROL OF PHARMACEUTICAL AND BIOLOGICAL PRODUCTS   (China)

^b INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

Cephalosporins; Impurity; MMTD; Qualification; Zebrafish embryo toxicity test

Indexed keywords

2 MERCAPTO 5 METHYL 1,3,4 THIADIAZOLE; 7 AMINOCEPHALOSPORANIC ACID; CEFAZEDONE; CEFAZOLIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRADYCARDIA; BRAIN HEMORRHAGE; CLINICAL EVALUATION; DEFORMITY; ECTODERM; EMBRYO; EMBRYO DEVELOPMENT; GENE MUTATION; MESODERM; NONHUMAN; ORGANOGENESIS; PERICARDIUM; PRIORITY JOURNAL; SHORT STATURE; STRESS; TERATOGENICITY; TOXICITY TESTING; YOLK SAC; ZEBRA FISH;

ANIMALS; ANTI-BACTERIAL AGENTS; CEFAZOLIN; CEPHALOSPORINS; EMBRYONIC DEVELOPMENT; FEMALE; PREGNANCY; STRUCTURE-ACTIVITY RELATIONSHIP; TERATOGENS; THIADIAZOLES; TOXICITY TESTS; ZEBRAFISH;

EID: 78349240026     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201000005     Document Type: Article

References (16)

1. G. S. Singh, Mini Rev. Med. Chem. 2004, 4, 93-109.
2. K. Fujimoto, S. Ishihara, H. Yanagisawa, J. Ide, et al,., J. Antibiotics 1987, 40, 370-384.
3. S. Negi, M. Yamanaka, I. Sugiyama, Y. Komatsu, et al,., J. Antibiotics 1994, 47, 1507-1525.
4. H. Sadaki, T. Imazumi, T. Inaba, T. Hirakawa, et al,., Yakugaku Zasshi 1986, 106, 129-146.
5. K. Sakagami, K. Atsumi, A. Tamura, T. Yoshida, et al,., J. Antibiotics 1990, 43, 1047-1050.
6. E. Caselli, R. A. Powers, L. C. Blasczcak, C. Y. E. Wu, et al,., Chem. Biol. 2001, 8, 17-31.
7. J. R. Hwu, K. S. Ethiraj, G. H. Hakimelahi, Mini Rev. Med. Chem. 2003, 3, 305-313.
8. R. D. Beger, Drug Discov. Today 2006, 11, 429-435.
9. T. P. Barros, W. K. Alderton, H. M. Reynolds, A. G. Roach, S. Berghmans, Br. J. Pharmacol. 2008, 154, 1400-1413.
10. A. L. Rubinstein, Expert Opin. Drug Metab. Toxicol. 2006, 2, 231-240.
11. A. C. MacRae, R. T. Peterson, Chem. Biol. 2003, 10, 901-908.
12. H. C. Ou, D. W. Raible, E. W. Rubel, Hearing Res. 2007, 233, 46-53.
13. D. M. Hentschel, K. M. Park, L. Cilenti, A. S. Zervos, et al,., Am. J. Physiol. Renal Physiol. 2005, 288, F923-F929.
14. M. Westerfield, (Ed.), The Zebrafish Book. A guide for the laboratory use of zebrafish (Danio rerio), 4th ed., Univ. of Oregon Press, Eugene, OR, USA 2000.
15. B. Vilanova, F. Munoz, J. Donoso, J. Frau, F. G. Blanco, J. Pharm. Sci. 1994, 83, 322-327.
16. V. L. Cunningham, S. P. Binks, M. J. Olson, Regul. Toxicol. Pharmacol. 2009, 53, 39-45.