Human wound contraction: Collagen organization, fibroblasts, and myofibroblasts

Plastic and Reconstructive Surgery

Volumn 102, Issue 1, 1998, Pages 124-134

  Berry, David P ^b   Harding, Keith G ^b   Stanton, Michael R ^b   Jasani, Bharat ^b   Ehrlich, H Paul ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; COLLAGEN FIBER;

ADULT; ARTICLE; CELL DENSITY; CLINICAL ARTICLE; FEMALE; FIBROBLAST; GRANULATION TISSUE; HUMAN; HUMAN TISSUE; MALE; MYOFIBROBLAST; PILONIDAL SINUS; POLARIZATION MICROSCOPY; PRIORITY JOURNAL; SCAR; WOUND CLOSURE; WOUND CONTRACTION;

ACTINS; ADIPOSE TISSUE; ADULT; ANIMALS; AZO COMPOUNDS; BIOPSY; CELL COUNT; CELL MOVEMENT; CICATRIX; COLLAGEN; COLORING AGENTS; FEMALE; FIBROBLASTS; GRANULATION TISSUE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MICROSCOPY, POLARIZATION; MUSCLE, SKELETAL; PILONIDAL SINUS; SKIN; TIME FACTORS; WOUND HEALING;

EID: 0031775195     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006534-199807000-00019     Document Type: Article

References (19)

1. Marks, J., Harding, K. G., Hughes, L. E., and Ribeiro, C. D. Pilonidal sinus excision: Healing by open granulation. Br. J. Surg. 72: 637, 1985.
2. Marks, J., Hughes, L. E., Harding, K. G., Campbell, H., and Ribeiro, C. D. Prediction of healing time as an aid to the management of open granulating wounds. World J. Surg. 7: 641, 1983.
3. Marks, J., Harding, K. G., and Hughes, L. E. Staphylococcal infection of open granulating wounds. Br. J. Surg. 74: 95, 1987.
4. Wood, R. A. B., and Hughes, L. E. Silicone foam sponge for pilonidal sinus: A new technique for dressing open granulating wounds. Br. Med. J. 4: 131, 1975.
5. Butterworth, R. J. M.D. Thesis. Leicester University, 1992.
6. Hartwell, S. W. Surgical wounds in human beings: A histologic study of healing with practical applications: Fibrous healing. Arch. Surg. 21: 76, 1930.
7. Carrel, A., and Hartmann, A. Cicatrization of wounds: I. The relation between the size of a wound and the rate of its cicatrization. J. Exp. Med. 24: 429, 1916.
8. Ehrlich, H. P., and Rajaratnam, B. J. M. Cell locomotion forces versus cell contraction forces for collagen lattice contraction: An in vitro model of wound contraction. Tissue Cell 22: 407, 1990.
9. Pickering, J. G., and Boughner, D. R. Quantitative assessment of the age of fibrotic lesions using polarized light microscopy and digital image analysis. Am. J. Pathol. 138: 1225, 1991.
10. Darby, I., Skalli, O., and Gabbiani, G. Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab. Invest. 63: 21, 1990.
11. Skalli, O., Ropraz, P., Trzeciak, A., Benzonana, G., Gillessen, D., and Gabbiani, G. A monoclonal antibody against a smooth muscle actin: A new probe for smooth muscle differentiation. J. Cell Biol. 103: 2787, 1986.
12. Gabbiani, G. The biology of the myofibroblast. Kidney Int. 41: 530, 1992.
13. Majno, G., Gabbiani, G., Hirschel, B. J., Ryan, G. B., and Statkov, P. R. Contraction of granulation tissue in vitro: Similarity to smooth muscle. Science 173: 548, 1971.
14. Eddy, R. J., Petro, J. A., and Tomasek, J. J. Evidence for the nonmuscle nature of the "myofibroblast" of granulation tissue and hypertrophic scar: An immunofluorescence study. Am. J. Pathol. 130: 252, 1988.
15. Rungger-Brandle, E., and Gabbiani, G. The role of cytoskeleton and cytocontractile elements in pathologic processes. Am. J. Pathol. 110: 359, 1983.
16. Constantine, V. S., and Mowry, R. W. Selective staining of human dermal collagen: II. The use of picrosirius red F3BA with polarization microscopy. J. Invest. Dermatol. 50: 419, 1968.
17. Van Winkle, W., Jr. Wound contraction. Surg. Gynecol. Obstet. 125: 131, 1967.
18. Ehrlich, H. P., Desmouliere, A., Diegelmann, R. F., et al. Morphological and immunochemical differences between keloid and hypertrophic scar. Am. J. Pathol. 145: 105, 1994.
19. Hembry, R. M., Bernanke, D. H., Hiyashi, K., Trelstad, R. L., and Ehrlich, H. P. Morphologic examination of mesenchymal cells in healing wounds of normal and tight skin mice. Am. J. Pathol. 125: 81, 1986.