Developing dual functional allosteric modulators of GABAA receptors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 23, 2010, Pages 8374-8382

  Liu, Xiaodong F ^a   Chang, Hui Fang ^a   Schmiesing, Richard Jon ^a   Wesolowski, Steven S ^a   Knappenberger, Katharine S ^a   Arriza, Jeffrey L ^a   Chapdelaine, Marc J ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Allosteric modulator; Anxiety; Benzodiazepine; Cinnoline; Cognition; GABAA receptor; Inverse agonist; Quinoline; Subtype selectivity; TEVC

Indexed keywords

(4 AMINO 7 FLUORO 8 (PYRIMIDIN 2 YL)CINNOLIN 3 YL)(3 METHYLAZETIDIN 1 YL)METHANONE; (4 AMINO 7 FLUORO 8 (PYRIMIDIN 2 YL)CINNOLIN 3 YL)(3,3 DIFLUOROAZETIDIN 1 YL)METHANONE; (4 AMINO 7 FLUORO 8 (PYRIMIDIN 2 YL)CINNOLIN 3 YL)(AZETIDIN 1 YL)METHANONE; (4 AMINO 8 (PYRIMIDIN 2 YL)CINNOLIN 3 YL)(3 METHYLAZETIDIN 1 YL)METHANONE; (4 AMINO 8 (PYRIMIDIN 2 YL)CINNOLIN 3 YL)(3,3 DIFLUOROAZETIDIN 1 YL)METHANONE; (4 AMINO 8 (PYRIMIDIN 2 YL)CINNOLIN 3 YL)(AZETIDIN 1 YL)METHANONE; 4 AMINO 7 FLUORO N PROPYL 8 (PYRIMIDIN 2 YL)CINNOLINE 3 CARBOXAMIDE; 4 AMINO 8 (5 (AZETIDINE 1 CARBONYL)PYRIDIN 3 YL) N PROPYLCINNOLINE 3 CARBOXAMIDE; 4 AMINO N CYCLOPROPYL 7 FLUORO 8 (PYRIMIDIN 2 YL)CINNOLINE 3 CARBOXAMIDE; 4 AMINO N CYCLOPROPYL 8 (PYRIMIDIN 2 YL)CINNOLINE 3 CARBOXAMIDE; 4 AMINO N PROPYL 8 (PYRIMIDIN 2 YL)CINNOLINE 3 CARBOXAMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; 9 AMINO 2 CYCLOBUTYL 5 (PYRIMIDIN 2 YL) 2,3 DIHYDRO 1H PYRROLO[3,4 B]QUINOLIN 1 ONE; 9 AMINO 2 CYCLOBUTYL 5 (PYRIMIDIN 5 YL) 2,3 DIHYDRO 1H PYRROLO[3,4 B]QUINOLIN 1 ONE; AZETIDIN 1 YL(5 (TRIMETHYLSTANNYL)PYRIDIN 3 YL)METHANONE; AZETIDIN 1 YL(5 BROMOPYRIDIN 3 YL)METHANONE; DIAZEPAM; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ALLOSTERIC REGULATION; BENZODIAZEPINES; HETEROCYCLIC COMPOUNDS, 2-RING; PATCH-CLAMP TECHNIQUES; QUANTUM THEORY; QUINOLINES; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78249282904     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.09.058     Document Type: Article

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