The flavonoid quercetin transiently inhibits the activity of taxol and nocodazole through interference with the cell cycle

Nutrition and Cancer

Volumn 62, Issue 8, 2010, Pages 1025-1035

  Samuel, Temesgen ^a   Fadlalla, Khalda ^a   Turner, Timothy ^a   Yehualaeshet, Teshome E ^a  

^a TUSKEGEE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN B1; NOCODAZOLE; PACLITAXEL; PROTEIN P53; QUERCETIN;

APOPTOSIS; ARTICLE; CANCER CELL; CELL ADHESION; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CLONOGENESIS; COLONY FORMATION; COLORECTAL CANCER; DRUG EFFECT; HUMAN; HUMAN CELL; MICROTUBULE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL ADHESION; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN B1; FOOD-DRUG INTERACTIONS; G2 PHASE; HUMANS; MICROTUBULES; NEOPLASMS; NOCODAZOLE; OSMOLAR CONCENTRATION; PACLITAXEL; QUERCETIN; TIME FACTORS; TUBULIN; TUBULIN MODULATORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 78249263220     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635581.2010.492087     Document Type: Article

References (30)

1. Kirsh VA, Peters U, et al.: Prospective study of fruit and vegetable intake and risk of prostate cancer. J Natl Cancer Inst 99, 1200-1209, 2007. (Pubitemid 47233070)
2. Lunet N, Valbuena C, et al.: Fruit and vegetable consumption and gastric cancer by location and histological type: case-control and meta-analysis. Eur J Cancer Prev 16, 312-327, 2007.
3. Gonzalez CA, Pera G, et al.: Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Int J Cancer 118, 2559-2566, 2006.
4. Millen AE, Subar AF, et al.: Fruit and vegetable intake and prevalence of colorectal adenoma in a cancer screening trial. Am J Clin Nutr 86, 1754-1764, 2007.
5. He X and Liu RH: Phytochemicals of apple peels: isolation, structure elucidation, and their antiproliferative and antioxidant activities. J Agric Food Chem 56, 9905-9910, 2008.
6. Harnly JM, Doherty RF, et al.: Flavonoid content of U. S.fruits, vegetables, and nuts. J Agric Food Chem 54, 9966-9977, 2006.
7. Huang Z, Wang B, et al.: Total phenolics and antioxidant capacity of indigenous vegetables in the southeast United States: Alabama Collaboration for Cardiovascular Equality Project. Int J Food Sci Nutr 60, 100-108, 2007.
8. Mertens-Talcott SU and Percival SS: Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lett 218, 141-151, 2005.
9. Nguyen TT, Tran E, et al.: The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis 25, 647-659, 2004.
10. Huynh H, Nguyen TT, et al.: Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)-and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation. Int J Oncol 23, 821-829, 2003.
11. Ong CS, Tran E, et al.: Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions. Oncol Rep 11, 727-733, 2004.
12. Granado-Serrano AB, Angeles Martin M, et al.: Time-course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cells. Mol Nutr Food Res 52, 457-464, 2008.
13. Kim WK, Bang MH, et al.: Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. J Nutr Biochem 16, 155-162, 2005.
14. Zhang XM, Huang SP, et al.: Quercetin inhibits the invasion of murine melanoma B16-BL6 cells by decreasing pro-MMP-9 via the PKC pathway. Cancer Chemother Pharmacol 53, 82-88, 2004.
15. Gee JM, Hara H, et al.: Suppression of intestinal crypt cell proliferation and aberrant crypt foci by dietary quercetin in rats. Nutr Cancer 43, 193-201, 2002.
16. Ramos S: Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways. Mol Nutr Food Res 52, 507-526, 2008.
17. Block KI, Mark A C K, Mead N, Tothy PK, Newman RA, et al.: Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials. Int J Cancer 123, 1227-1239, 2008.
18. Bairati I, Meyer F, Gelinas M, Fortin A, Nabid A, et al.: A randomized trial of antioxidant vitamins to prevent second primary cancers in head and neck cancer patients. J Natl Cancer Inst 97, 481-488, 2005. (Pubitemid 40590429)
19. Block KI, Koch AC, et al.: Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of the evidence from randomized controlled trials. Cancer Treat Rev 33, 407-418, 2007.
20. Lawenda BD, Kelly KM, et al.: Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? J Natl Cancer Inst 100, 773-783, 2008.
21. Franken NA, Rodermond HM, et al.: Clonogenic assay of cells in vitro. Nat Protoc 1, 2315-2319, 2006.
22. Samuel T, Okada K, et al.: cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. Cancer Res 65, 210-218, 2005.
23. Murtaza I, Marra G, et al.: A preliminary investigation demonstrating the effectofquercetinonthe expressionofgenes relatedtocell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray. Biotechnol Appl Biochem 45 (Pt 1), 29-36, 2006.
24. Jackman M, Lindon C, et al.: Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat Cell Biol 5, 143-148, 2003.
25. Béroud C and Soussi T: The UMD-p53 database: new mutations and analysis tools. Hum Mutat 21, 176-181, 2003.
26. Magali Olivier RE, Hollstein M, Khan MA, Harris CC, and Hainaut P: The IARC TP53 database: new online mutation analysis and recommendations to users. Hum Mutat 19, 607-614, 2002.
27. Valko M, Rhodes CJ, et al.: Free radicals, metals, and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160, 1-40, 2006.
28. Liu FT, Agrawal SG, et al.: Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib. Blood 112, 3835-3846, 2008.
29. Golden EB, Lam PY, et al.: Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors. Blood 5927-5937, 2009.
30. Heaney ML, Gardner JR, et al.: Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs. Cancer Res 68, 8031-8038, 2008.