Tuning hydrophobicity of highly cationic tetradecameric Gramicidin S analogues using adamantane amino acids

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 23, 2010, Pages 8403-8409

  Knijnenburg, Annemiek D ^a   Kapoerchan, Varsha V ^a   Spalburg, Emile ^b   De Neeling, Albert J ^b   Mars Groenendijk, Roos H ^c   Noort, Daan ^c   Van Der Marel, Gijs A ^a   Overkleeft, Herman S ^a   Overhand, Mark ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c TNO   (Netherlands)

Author keywords

Sheet; Amphipathicity; Cationic antimicrobial peptides; Gramicidin S; MRSA

Indexed keywords

ADAMANTANE; AMINO ACID; CATION; GRAMICIDIN S; POLYPEPTIDE ANTIBIOTIC AGENT;

AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; AMPHIPATHICITY; ARTICLE; BACILLUS CEREUS; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BIOLOGICAL ACTIVITY; CHEMICAL PHENOMENA; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HYDROPHOBICITY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PEPTIDE SYNTHESIS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE ANALYSIS;

ADAMANTANE; AMINO ACID SEQUENCE; AMINO ACIDS; ANTI-INFECTIVE AGENTS; CATIONS; CIRCULAR DICHROISM; GRAMICIDIN; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

EID: 78249263205     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.09.018     Document Type: Article

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