1,3-Diphenyl-1H-pyrazole derivatives as a new series of potent PPARγ partial agonists

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 23, 2010, Pages 8315-8323

  Choi, Jiwon ^a   Park, Yunsun ^a   Lee, Hui Sun ^a   Yang, Young ^a   Yoon, Sukjoon ^a  

^a Sookmyung Women's University   (South Korea)

Author keywords

Binding mode analysis; Comparative molecular field analysis (CoMFA); Computer aided drug discovery; Molecular docking; Peroxisome proliferators activated receptor (PPAR); Pyrazole

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PYRAZOLE DERIVATIVE; ROSIGLITAZONE; SP 3300; SP 3301; SP 3302; SP 3303; SP 3304; SP 3305; SP 3306; SP 3400; SP 3401; SP 3402; SP 3403; SP 3404; SP 3405; SP 3406; SP 3407; SP 3408; SP 3409; SP 3410; SP 3411; SP 3412; SP 3413; SP 3414; SP 3415; SP 3416; SP 3417; SP 3418; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; COMPARATIVE MOLECULAR FIELD ANALYSIS; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; IN VITRO STUDY;

BINDING SITES; COMPUTER SIMULATION; HEK293 CELLS; HUMANS; PPAR GAMMA; PROTEIN STRUCTURE, TERTIARY; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78249260631     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.09.068     Document Type: Article

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