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1
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38349100690
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For recent reviews of enamine and iminium ion catalysis, see
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For recent reviews of enamine and iminium ion catalysis, see:, S. Mukherjee, J. W. Yang, S. Hoffmann, B. List, Chem. Rev. 2007, 107, 5471
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Erkkilä, A.1
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Pihko, P.M.3
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3
-
-
78249233673
-
-
A search of the Beilstein database revealed over 9000 natural products containing a five-membered nitrogen heterocycle.
-
A search of the Beilstein database revealed over 9000 natural products containing a five-membered nitrogen heterocycle.
-
-
-
-
4
-
-
77951228078
-
-
For a review of the addition of metal enolate derivatives onto unactivated C-C multiple bonds, see.
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For a review of the addition of metal enolate derivatives onto unactivated C-C multiple bonds, see:, F. Dénès, A. Pérez-Luna, F. Chemla, Chem. Rev. 2010, 110, 2366.
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Dénès, F.1
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Chemla, F.3
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5
-
-
78249272426
-
-
For related Pd and Pd/Cu-catalysed cyclisations of 4-alkynyl malonates resulting in the formation of two C-C bonds, see
-
For related Pd and Pd/Cu-catalysed cyclisations of 4-alkynyl malonates resulting in the formation of two C-C bonds, see
-
-
-
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6
-
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0025046678
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G. Fournet, G. Balme, B. Van Hemelryck, J. Goré, Tetrahedron Lett. 1990, 31, 5147
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Fournet, G.1
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7
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0025899436
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G. Fournet, G. Balme, J. Goré, Tetrahedron 1991, 47, 6293
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Tetrahedron
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Fournet, G.1
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8
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0026075001
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D. Bouyssi, G. Balme, J. Goré, Tetrahedron Lett. 1991, 32, 6541
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Tetrahedron Lett.
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Bouyssi, D.1
Balme, G.2
Goré, J.3
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1842713137
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D. Bruyère, D. Bouyssi, G. Balme, Tetrahedron 2004, 60, 4007
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(2004)
Tetrahedron
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-
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Bruyère, D.1
Bouyssi, D.2
Balme, G.3
-
14
-
-
78249258824
-
-
For other related Pd-catalysed cyclisations of malonates and alkynes with the formation of two C-C bonds, see
-
For other related Pd-catalysed cyclisations of malonates and alkynes with the formation of two C-C bonds, see
-
-
-
-
15
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33645783912
-
-
L.-N. Guo, X.-H. Duan, H.-P. Bi, X.-Y. Liu, Y.-M. Liang, J. Org. Chem. 2006, 71, 3325
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Guo, L.-N.1
Duan, X.-H.2
Bi, H.-P.3
Liu, X.-Y.4
Liang, Y.-M.5
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16
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33846111706
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D. H. Zhang, Z. J. Liu, E. K. Yum, R. C. Larock, J. Org. Chem. 2007, 72, 251.
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Zhang, D.H.1
Liu, Z.J.2
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Larock, R.C.4
-
17
-
-
78249238618
-
-
For related metal-mediated and metal-catalysed cyclisations of 4-alkynyl malonates resulting in the formation of one C-C bond see the following: using Pd
-
For related metal-mediated and metal-catalysed cyclisations of 4-alkynyl malonates resulting in the formation of one C-C bond see the following: using Pd
-
-
-
-
18
-
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0025980186
-
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N. Monteiro, G. Balme, J. Goré, Tetrahedron Lett. 1991, 32, 1645
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Monteiro, N.1
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19
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0026499192
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N. Monteiro, J. Goré, G. Balme, Tetrahedron 1992, 48, 10103
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Monteiro, N.1
Goré, J.2
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20
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34548528309
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H. P. Bi, X. Y. Liu, F. R. Gou, L. N. Guo, X. H. Duan, Y. M. Liang, Org. Lett. 2007, 9, 3527
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Bi, H.P.1
Liu, X.Y.2
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Duan, X.H.5
Liang, Y.M.6
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21
-
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53949114601
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H. P. Bi, X. Y. Liu, F. R. Gou, L. N. Guo, X.-H. Duan, X. Z. Shu, Y. M. Liang, Angew. Chem. 2007, 119, 7198
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Bi, H.P.1
Liu, X.Y.2
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Guo, L.N.4
Duan, X.-H.5
Shu, X.Z.6
Liang, Y.M.7
-
23
-
-
45249089674
-
-
using Ni
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H. P. Bi, L. N. Guo, F. R. Gou, X. H. Duan, X. Y. Liu, Y. M. Liang, J. Org. Chem. 2008, 73, 4713; using Ni
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Bi, H.P.1
Guo, L.N.2
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Duan, X.H.4
Liu, X.Y.5
Liang, Y.M.6
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24
-
-
43449093757
-
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using Cu
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F. R. Gou, H. P. Bi, L. N. Guo, Z. H. Guan, X. Y. Liu, Y. M. Liang, J. Org. Chem. 2008, 73, 3837; using Cu
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Gou, F.R.1
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25
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0033547993
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D. Bouyssi, N. Monteiro, G. Balme, Tetrahedron Lett. 1999, 40, 1297
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Bouyssi, D.1
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0032509412
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O. Kitagawa, T. Suzuki, T. Inoue, Y. Watanabe, T. Taguchi, J. Org. Chem. 1998, 63, 9470
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O. Kitagawa, T. Suzuki, T. Inoue, T. Taguchi, Tetrahedron Lett. 1998, 39, 7357
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30
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73349120574
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using Fe
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C. L. Deng, R. J. Song, Y. L. Liu, J. H. Li, Adv. Synth. Catal. 2009, 351, 3096; using Fe
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Adv. Synth. Catal.
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Deng, C.L.1
Song, R.J.2
Liu, Y.L.3
Li, J.H.4
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31
-
-
78249288253
-
-
reference [6h]; using only Li, Na or K bases
-
reference [6h]; using only Li, Na or K bases
-
-
-
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33
-
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0033546252
-
-
using Sc
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O. Kitagawa, T. Suzuki, H. Fujiwara, M. Fujita, T. Taguchi, Tetrahedron Lett. 1999, 40, 4585; using Sc
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Kitagawa, O.1
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34
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52649180623
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using positive iodine
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K. Gao, J. Wu, Org. Lett. 2008, 10, 2251; using positive iodine
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Gao, K.1
Wu, J.2
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35
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33847031343
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H. P. Bi, L.-N. Guo, X. H. Duan, F. R. Gou, S. H. Huang, X. Y. Liu, Y. M. Liang, Org. Lett. 2007, 9, 397.
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Bi, H.P.1
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Huang, S.H.5
Liu, X.Y.6
Liang, Y.M.7
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36
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0037121609
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S. Azoulay, N. Monteiro, G. Balme, Tetrahedron Lett. 2002, 43, 9311
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Azoulay, S.1
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37
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0033547929
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B. Clique, N. Monteiro, G. Balme, Tetrahedron Lett. 1999, 40, 1301.
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Clique, B.1
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73349130987
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K. Takahashi, M. Midori, K. Kawano, J. Ishihara, S. Hatakeyama, Angew. Chem. 2008, 120, 6340
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Takahashi, K.1
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Ishihara, J.4
Hatakeyama, S.5
-
40
-
-
78249241609
-
-
For related metal-catalysed and metal-mediated reactions for the synthesis of 3-alkyl or 3-alkylidene pyrrolidines, see
-
For related metal-catalysed and metal-mediated reactions for the synthesis of 3-alkyl or 3-alkylidene pyrrolidines, see
-
-
-
-
42
-
-
19344368399
-
-
L. Martinon, S. Azoulay, N. Monteiro, E. P. Kündig, G. Balme, J. Organomet. Chem. 2004, 689, 3831
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Martinon, L.1
Azoulay, S.2
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Kündig, E.P.4
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43
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33646236946
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S. Morikawa, S. Yamazaki, Y. Furusaki, N. Amano, K. Zenke, K. Kakiuchi, J. Org. Chem. 2006, 71, 3540
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Morikawa, S.1
Yamazaki, S.2
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Amano, N.4
Zenke, K.5
Kakiuchi, K.6
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44
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-
53349131985
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E. O. Onyango, J. Tsurumoto, N. Imai, K. Takahashi, J. Ishihara, S. Hatakeyama, Angew. Chem. 2007, 119, 6823
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Onyango, E.O.1
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Takahashi, K.4
Ishihara, J.5
Hatakeyama, S.6
-
46
-
-
23444431603
-
-
The aminomalonates were readily prepared according to the method of Chai, see.
-
The aminomalonates were readily prepared according to the method of Chai, see:, C. L. L. Chai, J. A. Elix, P. B. Huleatt, Tetrahedron 2005, 61, 8722.
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Chai, C.L.L.1
Elix, J.A.2
Huleatt, P.B.3
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47
-
-
78249278251
-
-
For the cyclisation of a malonate anion onto a vinylpalladium species for the formation of an alkylidene pyrrolidinone, see reference [9d].
-
For the cyclisation of a malonate anion onto a vinylpalladium species for the formation of an alkylidene pyrrolidinone, see reference [9d].
-
-
-
-
48
-
-
78249289733
-
-
1H NMR NOE experiments. The E configuration of the remaining products was assigned by analogy.
-
1H NMR NOE experiments. The E configuration of the remaining products was assigned by analogy.
-
-
-
-
49
-
-
78249267672
-
-
The exo-methylene pyrrolidines can generally be removed by flash chromatography.
-
The exo-methylene pyrrolidines can generally be removed by flash chromatography.
-
-
-
-
50
-
-
78249250676
-
-
The base was added to a mixture of the substrates and the palladium catalyst in THF. No copper catalyst was used.
-
The base was added to a mixture of the substrates and the palladium catalyst in THF. No copper catalyst was used.
-
-
-
-
51
-
-
0006404162
-
-
For the synthesis of fully substituted alkylidene cyclopentanes by the cyclisation of substituted 4-pentynyl malonates by using Mn, see.
-
For the synthesis of fully substituted alkylidene cyclopentanes by the cyclisation of substituted 4-pentynyl malonates by using Mn, see:, K. Okuro, H. Alper, J. Org. Chem. 1996, 61, 5312.
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