BRAF mutation-selective inhibition of thyroid cancer cells by the novel MEK inhibitor RDEA119 and genetic-potentiated synergism with the mTOR inhibitor temsirolimus

International Journal of Cancer

Volumn 127, Issue 12, 2010, Pages 2965-2973

  Liu, Dingxie ^a   Xing, Joanna ^a   Trink, Barry ^a   Xing, Mingzhao ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

MEK inhibitor; MTOR Inhibitor; RDEA119; Temsirolimus; Thyroid cancer

Indexed keywords

BETA ACTIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RDEA 119; TEMSIROLIMUS; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BRAF GENE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; DRUG SENSITIVITY; GENE MUTATION; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE; PRIORITY JOURNAL; THYROID CANCER; TUMOR XENOGRAFT; WILD TYPE;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; DIPHENYLAMINE; DRUG SYNERGISM; FLOW CYTOMETRY; HUMANS; MAP KINASE KINASE KINASES; MICE; MICE, NUDE; MUTATION; PROTO-ONCOGENE PROTEINS B-RAF; SIROLIMUS; SULFONAMIDES; THYROID NEOPLASMS; TOR SERINE-THREONINE KINASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 78249243102     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25304     Document Type: Article

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