Hepatitis B virusXprotein promotes hypermethylation of p16INK4A promoter through upregulation of DNA methyltransferases in hepatocarcinogenesis

Experimental and Molecular Pathology

Volumn 89, Issue 3, 2010, Pages 268-275

  Zhu, Ya Zhen ^a,c   Zhu, Rong ^a   Shi, Lian Guo ^a   Mao, Yi ^b   Zheng, Guang Juan ^c   Chen, Qi ^a   Zhu, Hong Guang ^a  

^a FUDAN UNIVERSITY   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^c GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

Author keywords

DNA methyltransferase; Hepatitis B virus protein; Hepatocellular carcinoma; Methylation

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; HEPATITIS B VIRUS X PROTEIN; METHYL CPG BINDING PROTEIN 2; DNA (CYTOSINE 5 ) METHYLTRANSFERASE 1; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; TRANSACTIVATOR PROTEIN;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA METHYLATION; ENZYME REGULATION; ENZYME REPRESSION; EPIGENETICS; EXPRESSION VECTOR; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER CARCINOGENESIS; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ADULT; AGED; BIOSYNTHESIS; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; LIVER CELL CARCINOMA; LIVER TUMOR; MALE; METABOLISM; MIDDLE AGED; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE; VIROLOGY;

ADULT; AGED; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P16; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS; TRANSFECTION; UP-REGULATION;

EID: 78249232586     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2010.06.013     Document Type: Article

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