NK cell depletion delays corneal allograft rejection in baby rats

Molecular Vision

Volumn 16, Issue , 2010, Pages 1928-1935

  Schwartzkopff, Johannes ^a   Schlereth, Simona L ^a   Berger, Moritz ^a   Bredow, Laura ^a   Birnbaum, Florian ^a   Böhringer, Daniel ^a   Reinhard, Thomas ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2 RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; KERATOPLASTY; LEUKOCYTE MIGRATION; LYMPHOCYTE COUNT; LYMPHOCYTE MIGRATION; MACROPHAGE MIGRATION; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; RAT; T CELL DEPLETION;

ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD45; CELL MOVEMENT; CORNEA; CORNEAL TRANSPLANTATION; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNITY, INNATE; KILLER CELLS, NATURAL; LYMPHOCYTE DEPLETION; LYMPHOCYTE SUBSETS; MACROPHAGES; RATS; TRANSPLANTATION, HOMOLOGOUS;

EID: 78149481998     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Niederkorn JY, Chen PW, Mellon J, Stevens C, Mayhew E. Allergic airway hyperreactivity increases the risk for corneal allograft rejection. Am J Transplant 2009; 9:1017-26.
2. Althaus C, Sundmacher R. Keratoplasty in newborns with Peters' anomaly. Ger J Ophthalmol 1996; 5:31-5.
3. Reidy JJ. Penetrating keratoplasty in infancy and early childhood. Curr Opin Ophthalmol 2001; 12:258-61.
4. Yang LL, Lambert SR, Lynn MJ, Stulting RD. Long-term results of corneal graft survival in infants and children with peters anomaly. Ophthalmology 1999; 106:833-48.
5. Shapiro R, Sarwal MM. Pediatric kidney transplantation. Pediatr Clin North Am 2010; 57:393-400.
6. Gulati A, Sarwal MM. Pediatric renal transplantation: an overview and update. Curr Opin Pediatr 2010; 22:189-96.
7. Yamada J, Kurimoto I, Streilein JW. Role of CD4+T cells in immunobiology of orthotopic corneal transplants in mice. Invest Ophthalmol Vis Sci 1999; 40:2614-21.
8. Niederkorn JY, Stevens C, Mellon J, Mayhew E. Differential roles of CD8+ and CD8-T lymphocytes in corneal allograft rejection in 'high-risk' hosts. Am J Transplant 2006; 6:705-13.
9. Streilein JW. Ocular immune privilege: therapeutic opportunities from an experiment of nature. Nat Rev Immunol 2003; 3:879-89.
10. Niederkorn JY. Immune mechanisms of corneal allograft rejection. Curr Eye Res 2007; 32:1005-16.
11. Hos D, Bachmann B, Bock F, Onderka J, Cursiefen C. Agerelated changes in murine limbal lymphatic vessels and corneal lymphangiogenesis. Exp Eye Res 2008; 87:427-32.
12. Hori J, Streilein JW. Survival in high-risk eyes of epitheliumdeprived orthotopic corneal allografts reconstituted in vitro with syngeneic epithelium. Invest Ophthalmol Vis Sci 2003; 44:658-64.
13. Saban DR, Chauhan SK, Zhang X, El Annan J, Jin Y, Dana R. 'Chimeric' grafts assembled from multiple allodisparate donors enjoy enhanced transplant survival. Am J Transplant 2009; 9:473-82.
14. Huq S, Liu Y, Benichou G, Dana MR. Relevance of the direct pathway of sensitization in corneal transplantation is dictated by the graft bed microenvironment. J Immunol 2004; 173:4464-9.
15. Bachmann BO, Bock F, Wiegand SJ, Maruyama K, Dana MR, Kruse FE, Luetjen-Drecoll E, Cursiefen C. Promotion of graft survival by vascular endothelial growth factor a neutralization after high-risk corneal transplantation. Arch Ophthalmol 2008; 126:71-7.
16. Schwartzkopff J, Berger M, Birnbaum F, Böhringer D, Reinhard T. Accelerated Corneal Graft Rejection in Baby Rats. Br J Ophthalmol 2010; 94:1062-6.
17. Mayer K, Reinhard T, Reis A, Niehues T, Claas FH, Sundmacher R. Differential contribution of natural killer cells to corneal graft rejection in 3-week-old versus mature rats. Transplantation 2003; 76:578-82.
18. Kovarik J, Siegrist CA. Immunity in early life. Immunol Today 1998; 19:150-2.
19. Marshall-Clarke S, Reen D, Tasker L, Hassan J. Neonatal immunity: How well has it grown up? Immunol Today 2000; 21:35-41.
20. Slegers TP, Torres PF, Broersma L, van Rooijen N, van Rij G, van der Gaag R. Effect of macrophage depletion on immune effector mechanisms during corneal allograft rejection in rats. Invest Ophthalmol Vis Sci 2000; 41:2239-47.
21. Birnbaum F, Schwartzkopff J, Scholz C, Reis A, Reinhard T. The new malononitrilamide immunosuppressant FK778 prolongs corneal allograft survival in the rat keratoplasty model. Eye 2007; 21:1516-23.
22. van den Brink MR, Hunt LE, Hiserodt JC. In vivo treatment with monoclonal antibody 3.2.3 selectively eliminates natural killer cells in rats. J Exp Med 1990; 171:197-210.
23. Stenard F, Nguyen C, Cox K, Kambham N, Umetsu DT, Krams SM, Esquivel CO, Martinez OM. Decreases in circulating CD4+CD25hiFOXP3+ cells and increases in intragraft FOXP3+ cells accompany allograft rejection in pediatric liver allograft recipients. Pediatr Transplant 2009; 13:70-80.
24. Chauhan SK, Saban DR, Lee HK, Dana R. Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation. J Immunol 2009; 182:148-53.
25. Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z, Shimizu J, Takahashi T, Nomura T. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 2006; 212:8-27.
26. Adkins B, Leclerc C, Marshall-Clarke S. Neonatal adaptive immunity comes of age. Nat Rev Immunol 2004; 4:553-64.
27. Kirwan SE, Burshtyn DN. Regulation of natural killer cell activity. Curr Opin Immunol 2007; 19:46-54.
28. Freud AG, Caligiuri MA. Human natural killer cell development. Immunol Rev 2006; 214:56-72.
29. Hamrah P, Huq S, Liu Y, Zhang Q, Dana MR. Corneal immunity is mediated by a heterogenous population of antigen-presenting cells. J Leukoc Biol 2003; 74:172-8.
30. Claerhout I, Kestelyn P, Debacker V, Beele H, Leclercq G. Role of natural killer cells in the rejection process of corneal allografts in rats. Transplantation 2004; 77:676-82.
31. Van Rooijen N, Sanders A. Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J Immunol Methods 1994; 174:83-93.
32. Sonoda KH, Taniguchi M, Stein-Streilein J. Long-term survival of corneal allografts is dependent on intact CD1d-reactive NKT cells. J Immunol 2002; 168:2028-34.
33. Watte CM, Nakamura T, Lau CH, Ortaldo JR, Stein-Streilein J. Ly49 C/I-dependent NKT cell-derived IL-10 is required for corneal graft survival and peripheral tolerance. J Leukoc Biol 2008; 83:928-35.