Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus

Annals of the Rheumatic Diseases

Volumn 69, Issue 11, 2010, Pages 1983-1989

  Fürnrohr, Barbara G ^a,b   Wach, Sven ^a   Kelly, Jennifer A ^c   Haslbeck, Martin ^d   Weber, Christian K ^a   Stach, Christian M ^b   Hueber, Axel J ^e   Graef, Daniela ^a,b   Spriewald, Bernd M ^b   Manger, Karin ^f   Herrmann, Martin ^b   Kaufman, Kenneth M ^c   Frank, Summer G ^c   Goodmon, Ellen ^c   James, Judith A ^c   Schett, Georg ^b   Winkler, Thomas H ^a   Harley, John B ^c   Voll, Reinhard E ^a,b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

^f Rheumatology Practice   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 70; MESSENGER RNA; THYMINE; HSPA1A PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC CODE; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS; BIOSYNTHESIS; BLOOD; CASE CONTROL STUDY; CLINICAL TRIAL; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; MULTICENTER STUDY;

CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER;

EID: 78149473895     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2009.122630     Document Type: Article

References (44)

1. Hartl FU. Molecular chaperones in cellular protein folding. Nature 1996;381:571-9.
2. Buchner J. Supervising the fold: functional principles of molecular chaperones. FASEB J 1996;10:10-19. (Pubitemid 26035501)
3. Zügel U, Kaufmann SH. Role of heat shock proteins in protection from and pathogenesis of infectious diseases. Clin Microbiol Rev 1999;12:19-39. (Pubitemid 29055952)
4. De Nagel DC, Pierce SK. Heat shock proteins implicated in antigen processing and presentation. Semin Immunol 1991;3:65-71.
5. Srivastava P. Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol 2002;2:185-94.
6. Nardai G, Végh EM, Prohászka Z, et al. Chaperone-related immune dysfunction: an emergent property of distorted chaperone networks. Trends Immunol 2006;27:74-9.
7. Soti C, Pál C, Papp B, et al. Molecular chaperones as regulatory elements of cellular networks. Curr Opin Cell Biol 2005;17:210-15. (Pubitemid 40380946)
8. Ramachandran S, Bell RB. Heat shock protein 70 gene polymorphisms and multiple sclerosis. Tissue Antigens 1995;46:140-1.
9. Debler J, Schiemann U, Seybold U, et al. Heat-shock protein HSP70-2 genotypes in patients with Crohn's disease: a more severe clinical course with intestinal complications in presence of the PstI-polymorphism. Eur J Med Res 2003;8:120-4.
10. Clarimón J, Bertranpetit J, Boada M, et al. HSP70-2 (HSPA1B) is associated with noncognitive symptoms in late-onset Alzheimer's disease. J Geriatr Psychiatry Neurol 2003;16:146-50.
11. Ratanachaiyavong S, Demaine AG, Campbell RD, et al. Heat shock protein 70 (HSP70) and complement C4 genotypes in patients with hyperthyroid Graves' disease. Clin Exp Immunol 1991;84:48-52.
12. Pociot F, Rønningen KS, Nerup J. Polymorphic analysis of the human MHC-linked heat shock protein 70 (HSP70-2) and HSP70-Hom genes in insulin-dependent diabetes mellitus (IDDM). Scand J Immunol 1993;38:491-5.
13. Jarjour W, Reed AM, Gauthier J, et al. The 8.5-kb PstI allele of the stress protein gene, Hsp70-2: an independent risk factor for systemic lupus erythematosus in African Americans? Hum Immunol 1996;45:59-63.
14. Pablos JL, Carreira PE, Martín-Villa JM, et al. Polymorphism of the heat-shock protein gene HSP70-2 in systemic lupus erythematosus. Br J Rheumatol 1995;34:721-3.
15. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997;40:1725.
16. Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
17. Cantor RM, Yuan J, Napier S, et al. Systemic lupus erythematosus genome scan: support for linkage at 1q23, 2q33, 16q12-13, and 17q21-23 and novel evidence at 3p24, 10q23-24, 13q32, and 18q22-23. Arthritis Rheum 2004;50:3203-10.
18. Gaffney PM, Kearns GM, Shark KB, et al. A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families. Proc Natl Acad Sci USA 1998;95:14875-9.
19. Gray-McGuire C, Moser KL, Gaffney PM, et al. Genome scan of human systemic lupus erythematosus by regression modeling: evidence of linkage and epistasis at 4p16-15.2. Am J Hum Genet 2000;67:1460-9.
20. Nath SK, Namjou B, Hutchings D, et al. Systemic lupus erythematosus (SLE) and chromosome 16: confirmation of linkage to 16q12-13 and evidence for genetic heterogeneity. Eur J Hum Genet 2004;12:668-72.
21. Wakeland EK, Liu K, Graham RR, et al. Delineating the genetic basis of systemic lupus erythematosus. Immunity 2001;15:397-408. (Pubitemid 32907387)
22. Arnett FC. Genetic aspects of human lupus. Clin Immunol Immunopathol 1992;63:4-6.
23. Tan FK, Arnett FC. The genetics of lupus. Curr Opin Rheumatol 1998;10:399-408.
24. Rood MJ, van Krugten MV, Zanelli E, et al. TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus. Arthritis Rheum 2000;43:129-34.
25. Fernando MM, Stevens CR, Sabeti PC, et al. Identification of two independent risk factors for lupus within the MHC in United Kingdom families. PLoS Genet 2007;3:e192.
26. Milner CM, Campbell RD. Polymorphic analysis of the three MHC-linked HSP70 genes. Immunogenetics 1992;36:357-62.
27. Favatier F, Bornman L, Hightower LE, et al. Variation in hsp gene expression and Hsp polymorphism: do they contribute to differential disease susceptibility and stress tolerance? Cell Stress Chaperones 1997;2:141-55.
28. Böttcher A, Gaipl US, Fürnrohr BG, et al. Involvement of phosphatidylserine, alphavbeta3, CD14, CD36, and complement C1q in the phagocytosis of primary necrotic lymphocytes by macrophages. Arthritis Rheum 2006;54:927-38.
29. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-5.
30. Price AL, Patterson NJ, Plenge RM, et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006;38:904-9.
31. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for wholegenome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-75.
32. Barrett JC, Fry B, Maller J, et al. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-5.
33. Milner CM, Campbell RD. Structure and expression of the three MHC-linked HSP70 genes. Immunogenetics 1990;32:242-51.
34. Vargas-Alarcón G, Granados J, Martínez-Laso J, et al. Lack of association between the polymorphism at the heat-shock protein (HSP70-2) gene and systemic lupus erythematosus (SLE) in the Mexican mestizo population. Genes Immun 2000;1:367-70.
35. Singh R, Kølvraa S, Bross P, et al. Heat-shock protein 70 genes and human longevity: a view from Denmark. Ann N Y Acad Sci 2006;1067:301-8.
36. Singh R, Kolvraa S, Rattan SI. Genetics of human longevity with emphasis on the relevance of HSP70 as candidate genes. Front Biosci 2007;12:4504-13.
37. Morimoto RI, Santoro MG. Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection. Nat Biotechnol 1998;16:833-8.
38. Li Z, Srivastava P. Heat-shock proteins. Curr Protoc Immunol 2004;Appendix 1:Appendix 1T.
39. Macario AJ, Conway de Macario E. Chaperonopathies and chaperonotherapy. FEBS Lett 2007;581:3681-8.
40. Kawaguchi S, Hagiwara A, Suzuki M. Polymorphic analysis of the heat-shock protein 70 gene (HSPA1A) in Ménière's disease. Acta Otolaryngol 2008;128:1173-7.
41. Konings A, Van Laer L, Michel S, et al. Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations. Eur J Hum Genet 2009;17:329-35.
42. Qi Y, Niu WQ, Zhu TC, et al. Genetic interaction of Hsp70 family genes polymorphisms with high-altitude pulmonary edema among Chinese railway constructors at altitudes exceeding 4,000 meters. Clin Chim Acta 2009;405:17-22.
43. He M, Guo H, Yang X, et al. Functional SNPs in HSPA1A gene predict risk of coronary heart disease. PLoS ONE 2009;4:e4851.
44. Barcellos LF, May SL, Ramsay PP, et al. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. PLoS Genet 2009;5:e1000696.