Lack of association between the polymorphism at the heat-shock protein (HSP70-2) gene and systemic lupus erythematosus (SLE) in the Mexican Mestizo population

Genes and Immunity

Volumn 1, Issue 6, 2000, Pages 367-370

  Vargas Alarcon G ^a,b   Granados, J ^c   Martinez Laso J ^d   Gomez Casado E ^d   Zuniga J ^c   Salgado, N ^c   Hernandez Pacheco G ^a   Hesiquio, R ^a   Rodriguez Reyna T S ^c   Gamboa, R ^a   Alcocer Varela, J ^c   Arnaiz Villena, A ^d  

^a INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^b UNIVERSIDAD PANAMERICANA   (Mexico)

^c INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^d UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Genetic susceptibility; Heat shock protein; Systemic lupus erythematosus

Indexed keywords

HEAT SHOCK PROTEIN 70; HLA DR ANTIGEN; PRIMER DNA;

ALLELE; ARTICLE; CASE CONTROL STUDY; ETHNIC GROUP; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; IMMUNOLOGY; MEXICO; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS;

ALLELES; BASE SEQUENCE; CASE-CONTROL STUDIES; DNA PRIMERS; ETHNIC GROUPS; GENE FREQUENCY; GENOTYPE; HLA-DR ANTIGENS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MEXICO; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 0034252928     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6363692     Document Type: Article

References (22)

1. Dunckley H, Gatenby PA, Hawkins B, Naitos S, Serjeantson SW. Deficiency of C4A is a genetic determinant of SLE in 3 ethnic groups. J Immunogenet 1987; 14: 209-218.
2. Sargent CA, Dunham I, Trowsdale J et al. Human major histocompatibility complex contains genes for the major heat shock protein HSP70. Proc Natl Acad Sci USA 1989; 86: 1968-1972.
3. Beckmann RP, Mizzen LA, Welch WJ. Interaction of hsp70 with newly synthesized proteins: implications for protein folding and assembly. Science 1990; 248: 850-854.
4. Ratanachaiyavong S, Demaine AG, Campbell RD et al. Heat shock protein 70 (HSP70) and complement C4 genotypes in patients with hyperthyroid Graves' disease. Clin Exp Immunol 1991; 84: 48-52.
5. Pociot F, Ronningen KS, Nerup J. Polymorphic analysis of the human MHC-linked heat shock protein (HSP70-2) and HSP70-HOM genes in insulin-dependent diabetes mellitus (IDDM). Scand J Immunol 1993; 38: 491-495.
6. Partanen J, Milner C, Campbell RD, Maki M, Lipsanen V, Koskimies S. HLA-linked heat-shock protein 70 (HSP70-2) gene polymorphism and celiac disease. Tissue Antigens 1993: 41: 15-19.
7. Pablos JL, Carreira PE, Martin-Villa JM, Montalvo G, Arnaiz-Villena A, Gomez-Reino JJ. Polymorphism of the heat-shock protein gene HSP70-2 in SLE. B J Rheum 1995; 34: 721-723.
8. Jarjour W, Reed AM, Gauthier J, Hunt S, Winfield JB. The 8.5-kb PstI allele of the Stress Protein Gene, Hsp70-2. An independent risk factor for systemic lupus erythematosus in African Americans? Hum Immunol 1996; 45: 59-63.
9. Granados J, Vargas-Alarcón G, Andrade F, Melín-Aldana H, Alcocer-Varela J, Alarcón-Segovia D. The role of HLA-DR alleles and complotypes through the ethnic barrier in systemic lupus erythematosus in Mexicans. Lupus 1996; 5: 184-189.
10. Milner CM, Campbell RD. Structure and expression of the three MHC-linked HSP70 genes. Immunogenetics 1990; 32: 242-251.
11. Faile A, Nieto A, Mataran L, Martin J. HSP70 gene polymorphisms in ankylosing spondylitis. Tissue Antigens 1998; 51: 382-385.
12. Vinasco J, Beraun Y, Nieto A, Fraile A, Pareja E, Mataran L, Martin J. Heat shock protein 70 gene polymorphisms in rheumatoid arthritis. Tissue Antigens 1997; 50: 71-73.
13. Cascino I, Galeazzi M, Salvetti M et al. HSP70-1 promoter region polymorphism tested in three autoimmune diseases. Immunogenetics 1994; 39: 291-293.
14. Auger I, Escola JM; Gorver JP, Roudier J. HLA-DR4 and HLA-DR10 motifs that carry susceptibility to rheumatoid arthritis bind 70-kD heat shock protein. Nat Med 1996; 2: 306-310.
15. Rippmann F, Taylor WR, Rothbard JB, Green NM. A hypothetical model for the peptide binding domain of hsp70 based on the peptide binding domain of HLA. EMBO J 1991; 10: 1053-1059.
16. Zuñuga J, Vargas-Alarcón G, Osnaya N et al. Heat-shock protein (HSP70-2) allelic frequencies in three distinct Mexican populations. Genes and Immunity 1999; 1: 66-68.
17. Lisker R, Pérez-Briceño R, Granados J et al. Gene frequencies and admixture estimates in a Mexican City population. Am J Physical Anthropol 1986; 71: 203-207.
18. Lisker R, Pérez-Briceño R, Granados J, Babinsky V. Gene frequencies and admixture estimates in the State of Puebla, Mexico. Am J Physical Anthropol 1988; 76: 331-335.
19. Lisker R, Ramirez E, Pérez-Briceño R, Granados J, Babinsky V. Gene frequencies and admixture estimates in four Mexican Urban Centers. Hum Biology 1990; 62: 791-801.
20. Davis RW, Thomas M, Cameron J, St John TP, Padgett RA. Rapid DNA isolation for enzymatic and hybridization analysis. Methods Enzymol 1980; 65: 404-411.
21. Svejgaard A, Ryder LP. HLA and disease associations: detecting the strongest association. Tissue Antigens 1994; 43: 18-27.
22. Excoffier L, Slatkin M. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol Biol Evol 1995; 12: 921-927.