Baicalein inhibits nuclear factor-κB and apoptosis via c-FLIP and MAPK in d-GalN/LPS induced acute liver failure in murine models

Chemico-Biological Interactions

Volumn 188, Issue 3, 2010, Pages 526-534

  Wu, Yan Ling ^a   Lian, Li Hua ^a   Wan, Ying ^a   Nan, Ji Xing ^a  

^a YANBIAN UNIVERSITY   (China)

Author keywords

Baicalein; Bcl 2; C FLIP; D Galactosamine lipopolysaccharides; MAPK

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BAICALEIN; CASPASE 3; CYTOCHROME C; FLICE INHIBITORY PROTEIN; GALACTOSAMINE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INHIBITOR OF APOPTOSIS PROTEIN 2; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROTEIN BAX; PROTEIN BCL 2; SILYMARIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; X LINKED INHIBITOR OF APOPTOSIS;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; IN VIVO STUDY; LIVER FAILURE; LIVER INJURY; LIVER MITOCHONDRION; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION;

ALANINE TRANSAMINASE; ANIMALS; APOPTOSIS; ASPARTATE AMINOTRANSFERASES; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 3; CYTOCHROMES C; CYTOPROTECTION; DISEASE MODELS, ANIMAL; FLAVANONES; GALACTOSAMINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIPOPOLYSACCHARIDES; LIVER; LIVER FAILURE; MALE; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR NECROSIS FACTOR-ALPHA; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

MURINAE; MUS;

EID: 78149469030     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.09.008     Document Type: Article

References (25)

1. Decker K., Keppler D. Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. Rev. Physiol. Biochem. Pharmacol. 1974, 71:77-106.
2. Jeong Y.I., Jung I.D., Lee C.M., Chang J.H., Chun S.H., Noh K.T., Jeong S.K., Shin Y.K., Lee W.S., Kang M.S., Lee S.Y., Lee J.D., Park Y.M. The novel role of platelet-activating factor in protecting mice against lipopolysaccharide-induced endotoxic shock. PLoS ONE 2009, 4:e6503.
3. Thirunavukkarasu C., Uemura T., Wang L.F., Watkins S.C., Gandhi C.R. Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes. J. Cell. Physiol. 2005, 204:654-665.
4. Shao Z.H., Li C.Q., Vanden Hoek T.L., Becker L.B., Schumacker P.T., Wu J.A., Attele A.S., Yuan C.S. Extract from Scutellaria baicalensis Georgi attenuates oxidant stress in cardiomyocytes. J. Mol. Cell. Cardiol. 1999, 31:1885-1895.
5. Lebeau A., Esclaire F., Rostène W., Pélaprat D. Baicalein protects cortical neurons from beta-amyloid (25-35) induced toxicity. Neuroreport 2001, 12:2199-2202.
6. Ishige K., Schubert D., Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic. Biol. Med. 2001, 30:433-446.
7. Lee H.H., Yang L.L., Wang C.C., Hu S.Y., Chang S.F., Lee Y.H. Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. Brain Res. 2003, 986:103-113.
8. Suk K., Lee H., Kang S.S., Cho G.J., Choi W.S. Flavonoid baicalein attenuates activation-induced cell death of brain microglia. J. Pharmacol. Exp. Ther. 2003, 305:638-645.
9. Chang W.H., Chen C.H., Gau R.J., Lin C.C., Tsai C.L., Tsai K., Lu F.J. Effect of baicalein on apoptosis of the human HepG2 cell line was induced by mitochondrial dysfunction. Planta Med. 2002, 68:302-306.
10. Tong W.G., Ding X.Z., Adrian T.E. The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells. Biochem. Biophys. Res. Commun. 2002, 296:942-948.
11. Liu Z.L., Tanaka S., Horigome H., Hirano T., Oka K. Induction of apoptosis in human lung fibroblasts and peripheral lymphocytes in vitro by Shosaiko-to derived phenolic metabolites. Biol. Pharm. Bull. 2002, 25:37-41.
12. Li Y.C., Tyan Y.S., Kuo H.M., Chang W.C., Hsia T.C., Chung J.G. Baicalein induced in vitro apoptosis undergo caspases activity in human promyelocytic leukemia HL-60 cells. Food Chem. Toxicol. 2004, 42:37-43.
13. Wang J., Yu Y., Hashimoto F., Sakata Y., Fujii M., Hou D.X. Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells. Int. J. Mol. Med. 2004, 14:627-632.
14. Zhou Q.M., Wang S., Zhang H., Lu Y.Y., Wang X.F., Motoo Y., Su S.B. The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells. Acta Pharmacol. Sin. 2009, 30:1648-1658.
15. Liu C., Wu J., Xu K., Cai F., Gu J., Ma L., Chen J. Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway. J. Neurochem. 2010, 112:1500-1512.
16. Crocenzi F.A., Roma M.G. Silymarin as a new hepatoprotective agent in experimental cholestasis: new possibilities for an ancient medication. Curr. Med. Chem. 2006, 13:1055-1074.
17. Gloire G., Legrand-Poels S., Piette J. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem. Pharmacol. 2006, 72:1493-1505.
18. Osawa Y., Nagaki M., Banno Y., Yamada Y., Imose M., Nozawa Y., Moriwaki H., Nakashima S. Possible involvement of reactive oxygen species in d-galactosamine-induced sensitization against tumor necrosis factor-alpha-induced hepatocyte apoptosis. J. Cell. Physiol. 2001, 187:374-385.
19. Nathan C., Xie Q.W. Nitric oxide synthases: roles, tolls and controls. Cell 1994, 78:915-918.
20. Malhi H, Gores G.J., Lemasters J.J. Apoptosis and necrosis in the liver: a tale of two deaths?. Hepatology 2006, 43:S31-S44.
21. Zamzami N., Marchetti P., Castedo M., Zanin C., Vayssière J.L., Petit P.X., Kroemer G. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med. 1995, 181:1661-1672.
22. Tak P.P., Firestein G.S. NF-kappaB: a key role in inflammatory diseases. J. Clin. Invest. 2001, 107:7-11.
23. Yang J.K. FLIP as an anti-cancer therapeutic target. Yonsei Med. J. 2008, 49:19-27.
24. Deveraux Q.L., Reed J.C. IAP family proteins-suppressors of apoptosis. Genes Dev. 1999, 13:239-252.
25. Lian L.H., Wu Y.L., Wan Y., Li X., Xie W.X., Nan J.X. Anti-apoptotic activity of gentiopicroside in d-galactosamine/lipopolysaccharide-induced murine fulminant hepaticfailure. Chem. Biol. Interact. 2010, 188:127-133.