Autoimmunity and recurrent pregnancy losses

Clinical Reviews in Allergy and Immunology

Volumn 39, Issue 3, 2010, Pages 148-152

  Cervera, Ricard ^a   Balasch, Juan ^a  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

Antiphospholipid antibodies; Pregnancy loss; Systemic lupus erythematosus

Indexed keywords

PHOSPHOLIPID ANTIBODY;

AUTOIMMUNE DISEASE; AUTOIMMUNITY; DISEASE ASSOCIATION; HUMAN; NONHUMAN; RECURRENT ABORTION; REVIEW; VASCULAR DISEASE;

ABORTION, HABITUAL; ANTIBODIES, ANTIPHOSPHOLIPID; AUTOIMMUNITY; FEMALE; HUMANS; PREGNANCY;

EID: 78149465604     PISSN: 10800549     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12016-009-8179-1     Document Type: Review

References (66)

1. R Cervera J Balasch 2008 Bidirectional effects on autoimmunity and reproduction Hum Reprod Updat 14 359 366 1:CAS:528:DC%2BD1cXnt1SksLk%3D 10.1093/humupd/dmn013 (Pubitemid 351858975)
2. CE Boklage 1990 Survival probability of human conceptions from fertilization to term Int J Fertil 35 75 93 1:STN:280:DyaK3c3kvF2qtQ%3D%3D 1970983
3. AJ Wilcox CR Weinberg JF O'Connor, et al. 1988 Incidence of early loss of pregnancy N Engl J Med 319 189 194 1:STN:280:DyaL1c3ns1Snsw%3D%3D 10.1056/NEJM198807283190401 3393170
4. JF Miller E Williamson J Glue 1980 Fetal loss after implantation: a prospective study Lancet 2 554 556 1:STN:280:DyaL3M%2FivFGqug%3D%3D 10.1016/S0140-6736(80)91991-1 6106737
5. HH Hatasaka 1994 Recurrent miscarriage: epidemiologic factors, definitions and incidence Clin Obstet Gynecol 37 325 334
6. RG Roussev BD Kaider DE Price CB Coulam 1996 Laboratory evaluation of women experiencing reproductive failure Am J Reprod Immunol 35 415 420 1:STN:280:DyaK28zhslSiug%3D%3D 8739463
7. Carmona F, Balasch J (2002) Fetal and obstetric manifestations and infertility in the antiphospholipid syndrome. In: Asherson RA, Cervera R, Piette JC, Shoenfeld Y (eds) The antiphospholipid syndrome II: autoimmune thrombosis. Elsevier, Amsterdam, pp 205-211
8. RS Rai K Clifford H Cohen L Regan 1995 High prospective fetal loss rate in untreated pregnancies of women with recurrent miscarriage and antiphospholipid antibodies Hum Reprod 10 3301 3304 1:STN:280: DyaK28vhvFOjtw%3D%3D 8822463
9. M Empson M Lassere JC Craig J Scott 2002 Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials Obstet Gynecol 99 135 144 10.1016/S0029-7844(01)01646-5 11777524 (Pubitemid 34075480)
10. BT Oshiro RM Silver JR Scott H Yu DW Branch 1996 Antiphospholipid antibodies and fetal death Obstet Gynecol 87 489 493 1:STN:280: DyaK287nvFKqtw%3D%3D 10.1016/0029-7844(95)00498-X 8602296 (Pubitemid 26102729)
11. F Parazzini B Acaia D Faden M Lovotti G Marelli S Cortelazzo 1991 Antiphospholipid antibodies and recurrent abortion Obstet Gynecol 77 854 858 1:STN:280:DyaK3M3jt1Oksw%3D%3D 1903191
12. AL Parke D Wilson D Maier 1991 The prevalence of antiphospholipd antibodies in women with recurrent spontaneous abortion, women with successful pregnancies and women who have never been pregnant Arthritis Rheum 34 1231 1235 1:STN:280:DyaK38%2FivFSqtg%3D%3D 10.1002/art.1780341005 1930312
13. MA MacLean GP Cumming F McCall ID Walker JJ Walker 1994 The prevalence of lupus anticoagulant and anticardiolipin antibodies in women with a history of first trimester miscarriages Br J Obstet Gynaecol 101 103 106 1:STN:280:DyaK2c7jslKlsg%3D%3D 8305382
14. DL Yetman WH Kutteh 1996 Antiphospholipid antibody panels and recurrent pregnancy loss: prevalence of anticardiolipin antibodies compared with other antiphospholipid antibodies Fertil Steril 66 540 546 1:STN:280: DyaK28vhtlClsg%3D%3D 8816614
15. L Ziporen Y Shoenfeld 1998 Anti-phospholipid syndrome: from patient's bedside to experimental animal models and back to the patient's bedside Hematol Cell Ther 40 175 182 1:CAS:528:DyaK1cXns1KiurY%3D 9844811
16. Y Shoenfeld Y Sherer M Blank 1998 Antiphospholipid syndrome in pregnancy-animal models and clinical implications Scand J Rheumatol 107 33 36 1:STN:280:DyaK1cvjtFaqsQ%3D%3D Suppl
17. W Ikematsu FL Luan L La Rosa, et al. 1998 Human anticardiolipin monoclonal autoantibodies cause placental necrosis and fetal loss in BALB/c mice Arthritis Rheum 41 1026 1039 1:CAS:528:DyaK1cXktVCjsb8%3D 10.1002/1529- 0131(199806)41:6<1026::AID-ART9>3.0.CO;2-1 9627012 (Pubitemid 28265405)
18. ZM Sthoeger E Mozes B Tartakovsky 1993 Anti-cardiolipin antibodies induce pregnancy failure by impairing embryonic implantation Proc Natl Acad Sci USA 90 6464 6467 1:CAS:528:DyaK3sXltlOhsLs%3D 10.1073/pnas.90.14.6464 8341656
19. F De Wolf LO Carreras P Moerman J Vermylen A Van Assche M Renaer 1982 Decidual vasculopathy and extensive placental infarction in a patient with repeated thromboembolic accidents, recurrent fetal loss, and a lupus anticoagulant Am J Obstet Gynecol 142 829 834 6801984
20. RW Bendon J Wilson B Getahun J van der Bel-Kahn 1987 A maternal death due to thrombotic disease associated with anticardiolipin antibody Arch Pathol Lab Med 111 370 372 1:STN:280:DyaL2s7lsFymsQ%3D%3D 3827544
21. AE Gharavi SS Pierangeli EN Harris 2001 Mechanisms of pregnancy loss in antiphospholipid syndrome Clin Obstet Gynecol 44 11 19 1:STN:280: DC%2BD3M3isFShug%3D%3D 10.1097/00003081-200103000-00003 11219239 (Pubitemid 32156076)
22. HJ Out CD Kooijman HW Bruinse RH Derksen 1991 Histopathological findings in placentae from patients with intra-uterine fetal death and anti-phospholipid antibodies Eur J Obstet Gynecol Reprod Biol 41 179 186 1:STN:280: DyaK38%2FjvVegtw%3D%3D 10.1016/0028-2243(91)90021-C 1936501
23. MS Magid C Kaplan LR Sammaritano M Peterson ML Druzin MD Lockshin 1998 Placental pathology in systemic lupus erythematosus: a prospective study Am J Obstet Gynecol 179 226 234 1:STN:280:DyaK1czmvVCqsg%3D%3D 10.1016/S0002-9378(98) 70277-7 9704792
24. LO Carreras G Defreyn SJ Machin, et al. 1981 Arterial thrombosis, intrauterine death and "lupus" antiocoagulant: detection of immunoglobulin interfering with prostacyclin formation Lancet 1 244 246 1:STN:280:DyaL3M7itFCjtg%3D%3D 10.1016/S0140-6736(81)92087-0 6109901
25. AE Schorer PG Duane VL Woods DE Niewoehner 1992 Some antiphospholipid antibodies inhibit phospholipase A2 activity J Lab Clin Med 120 67 77 1:STN:280:DyaK38zgvVKksQ%3D%3D 1613330
26. LW Chamley EJ McKay NS Pattison 1993 Inhibition of heparin/antithrombin III cofactor activity by anticardiolipin antibodies: a mechanism for thrombosis Thromb Res 71 103 111 1:CAS:528:DyaK3sXmtVWmtLk%3D 10.1016/0049-3848(93)90176-O 8362374 (Pubitemid 23190635)
27. JH Walker CM Boustead JJ Koster M Bewley DA Waller 1992 Annexin V, a calcium-dependent phospholipid-binding protein Biochem Soc Trans 20 828 833 1:CAS:528:DyaK38XlsVGnsb4%3D 1487073
28. LR Sammaritano AE Gharavi C Soberano RA Levy MD Lockshin 1992 Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein J Clin Immunol 12 27 35 1:CAS:528:DyaK38XktVGksLw%3D 10.1007/BF00918270 1372614
29. JH Rand XX Wu S Guller, et al. 1994 Reduction of annexin-V (placental anticoagulant protein-I) on placental villi of women with antiphospholipid antibodies and recurrent spontaneous abortion Am J Obstet Gynecol 171 1566 1572 1:STN:280:DyaK2M7gtVehsQ%3D%3D 7802069
30. JH Rand XX Wu HA Andree, et al. 1997 Pregnancy loss in the antiphospholipid-antibody syndrome-a possible thrombogenic mechanism N Engl J Med 337 154 160 1:STN:280:DyaK2szkslaitw%3D%3D 10.1056/NEJM199707173370303 9219701 (Pubitemid 27306286)
31. TW Lyden E Vogt AK Ng PM Johnson NS Rote 1992 Monoclonal antiphospholipid antibody reactivity against human placental trophoblast J Reprod Immunol 22 1 14 1:STN:280:DyaK38zpsFKitQ%3D%3D 10.1016/0165-0378(92)90002-L 1522561
32. N Di Simone PL Meroni N Del Papa, et al. 2000 Antiphospholipid antibodies affect trophoblast gonadotrophin secretion through adhered beta-2-glycoportein I Arthritis Rheum 43 140 150 10.1002/1529-0131(200001)43:1<140::AID- ANR18>3.0.CO;2-P 10643710 (Pubitemid 30368223)
33. LW Chamley AM Duncalf MD Mitchell PM Johnson 1998 Action of anticardiolipina and antibodies to beta-2-glycoprotein I on trophoblast proliferation as a mechanism of fetal death Lancet 352 1037 1038 1:CAS:528:DyaK1cXmslCiu7k%3D 10.1016/S0140-6736(05)60080-3 9759755 (Pubitemid 28438584)
34. N Di Simone D Caliandro R Castellani S Ferrazani S De Carolis A Caruso 1999 Low-molecular weight heparin restore in-vitro trophoblast invasiveness and differentiation in presenceof immunoglobulin G fractions obtained from patients with antiphospholipid syndrome Hum Reprod 13 489 495 10.1093/humrep/14.2.489
35. NJ Sebire H Fox M Backos R Rai C Paterson L Regan 2002 Defective endovascular trophoblast invasion in primary antiphospholipid antibody syndrome-associated early pregnancy failure Hum Reprod 7 1067 1071 10.1093/humrep/17.4.1067
36. P Bose S Black M Kadyrov, et al. 2005 Heparin and aspirin attenuate placental apoptosis in vitro: implications for early pregnancy failure Am J Obstet Gynecol 192 23 30 1:CAS:528:DC%2BD2MXmslCntw%3D%3D 10.1016/j.ajog.2004. 09.029 15671997 (Pubitemid 40164214)
37. S Quenby S Mountfield JE Cartwright GS Whitley L Chamley G Vince 2005 Antiphospholipid antibodies precent extravillous trophoblast differentiation Fertil Steril 83 691 698 1:CAS:528:DC%2BD2MXjtVOks78%3D 10.1016/j.fertnstert. 2004.07.978 15749499 (Pubitemid 40348582)
38. R Shurtz-Swirski O Inbar M Blank, et al. 1993 In vitro effect of anticardiolipin autoantibodies upon total and pulsatile placental hCG secretion during early pregnancy Am J Reprod Immunol 29 206 210 1:STN:280: DyaK2c%2FgtVeltg%3D%3D 8397810
39. P Fishman R Bakimer M Blank D Sredni SY Djaldetti 1992 The putative role of cytokines in the induction of primary anti-phospholipid syndrome in mice Clin Exp Immunol 90 266 270 1:CAS:528:DyaK3sXlsl2mug%3D%3D 10.1111/j.1365-2249.1992. tb07940.x 1424285
40. P Fishman E Falach-Vaknine R Zigelman, et al. 1993 Prevention of fetal loss in experimental anti-phospholipid syndrome by in vitro administration of recombinant interleukin-3 J Clin Invest 41 1834 1877 10.1172/JCI116396
41. VM Holers G Girardi L Mo, et al. 2002 C3 activation is required for anti-phospholipid antibody-induced fetal loss J Exp Med 195 211 220 1:CAS:528:DC%2BD38XosFCnsA%3D%3D 10.1084/jem.200116116 11805148 (Pubitemid 34461265)
42. G Girardi J Berman P Redecha, et al. 2003 Complement C5a receptors and neutrophils mediate fetal injury in the antiphophospholipid syndrome J Clin Invest 112 1644 1654 1:CAS:528:DC%2BD3sXpslens74%3D 14660741
43. SS Pierangeli G Girardi ME Vega-Ostertag X Liu RG Espinola J Salmon 2005 Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia Arthritis Rheum 52 2120 2124 1:CAS:528:DC%2BD2MXnsl2gt7w%3D 10.1002/art.21157 15986360 (Pubitemid 40994335)
44. JH Rand XX Wu HA Andree, et al. 1998 Antiphospholipid antibodies accelerate plasma coagulation by inhibiting annexin-V binding to phospholipids: a "lupus procoagulant" phenomenon Blood 92 1652 1660 1:CAS:528:DyaK1cXls1Shsr0%3D 9716593
45. P Von Landenberg T Matthias J Zaech, et al. 2003 Antiprothrombin antibodies are associated with pregnancy loss in patients with the antiphospholipid syndrome Am J Reprod Immunol 49 51 56 10.1034/j.1600-0897.2003. 01153.x (Pubitemid 36612047)
46. WH Kutteh 2002 Autoimmune factors in assisted reproduction Minerva Ginecol 54 217 224 1:STN:280:DC%2BD38zitVCjsw%3D%3D 12063437
47. J Inagaki E Matsuura M Nomizu, et al. 2001 IgG anti-laminin 1 autoantibody and recurrent miscarriages Am J Reprod Immunol 45 232 238 1:STN:280:DC%2BD3MvntlCjtg%3D%3D 10.1111/j.8755-8920.2001.450406.x 11327550
48. D Bustos A Moret M Tambutti, et al. 2006 Autoantibodies in Argentine women with recurrent pregnancy loss Am J Reprod Immunol 55 201 207 1:CAS:528:DC%2BD28XjtlWlsL0%3D 10.1111/j.1600-0897.2005.00349.x 16451354 (Pubitemid 43329496)
49. I Marai HJA Carp S Shai R Shabo G Fishman Y Shoenfeld 2004 Autoantibody panel screening in recurrent miscarriages Am J Reprod Immunol 51 235 240 1:STN:280:DC%2BD2czgslektA%3D%3D 10.1111/j.1600-0897.2004.00153.x 15209393
50. Y Shoenfeld HJA Carp V Molina, et al. 2006 Autoantibodies and prediction of reproductive failure Am J Reprod Immunol 56 337 344 1:CAS:528: DC%2BD28XhtlCjtbfE 10.1111/j.1600-0897.2006.00434.x 17076678 (Pubitemid 44669330)
51. PL Meroni Y Shoenfeld 2008 Predictive, protective, orphan autoantibodies: the example of anti-phospholipid antibodies Autoimmun Rev 7 585 587 1:CAS:528:DC%2BD1cXhtlemsLfN 10.1016/j.autrev.2008.08.001 18706525
52. A Tincani CB Rebaioli M Frassi, et al. 2005 Pregnancy and autoimmunity: maternal treatment and maternal disease influence on pregnancy outcome Autoimmun Rev 4 423 428 1:CAS:528:DC%2BD2MXhtFeksb%2FP 10.1016/j.autrev.2005.03.001 16137607 (Pubitemid 41219320)
53. D Sène JC Piette P Cacoub 2008 Antiphospholipid antibodies, antiphospholipid syndrome and infections Autoimmun Rev 7 272 277 10.1016/j.autrev.2007.10.001 18295729 (Pubitemid 351284546)
54. GR Hughes 2008 Hughes syndrome (the antiphospholipid syndrome): ten clinical lessons Autoimmun Rev 7 262 266 10.1016/j.autrev.2007.11.017 18190889
55. RA Asherson R Cervera 2008 Microvascular and microangiopathic antiphospholipid-associated syndromes ("MAPS"): semantic or antisemantic? Autoimmun Rev 7 164 167 1:CAS:528:DC%2BD1cXis1Wgu7c%3D 10.1016/j.autrev.2007.11.009 18190872
56. JI Tuthill MA Khamashta 2009 Management of antiphospholipid syndrome J Autoimmun 33 92 98 1:CAS:528:DC%2BD1MXpvF2mt7Y%3D 10.1016/j.jaut.2009.05.002 19559568
57. OD Ortega-Hernandez N Agmon-Levin M Blank, et al. 2009 The physiopathology of the catastrophic antiphospholipid (Asherson's) syndrome: compelling evidence J Autoimmun 32 1 6 1:CAS:528:DC%2BD1MXhtlKks7Y%3D 10.1016/j.jaut.2008.10.003 19059760
58. PL Meroni 2008 Pathogenesis of the antiphospholipid syndrome: an additional example of the mosaic of autoimmunity J Autoimmun 30 99 103 1:CAS:528:DC%2BD1cXlvFSitg%3D%3D 10.1016/j.jaut.2007.11.014 18194729
59. Y Shoenfeld G Twig U Katz Y Sherer 2008 Autoantibody explosion in antiphospholipid syndrome J Autoimmun 30 74 83 1:CAS:528:DC%2BD1cXlvFSisw%3D%3D 10.1016/j.jaut.2007.11.011 18171610
60. I Cavazzana N Manuela C Irene, et al. 2007 Complement activation in anti-phospholipid syndrome: a clue for an inflammatory process? J Autoimmun 28 160 164 10.1016/j.jaut.2007.02.013 17419007 (Pubitemid 46680500)
61. N Gleicher R Weiner M Vietzke 2006 The impact of abnormal autoimmune function on reproduction: maternal and fetal consequences J Autoimmun 27 161 165 1:CAS:528:DC%2BD28Xht1SjsrvK 10.1016/j.jaut.2006.08.003 17029731 (Pubitemid 46048592)
62. Y Sakai T Atsumi M Ieko, et al. 2009 The effects of phosphatidylserine- dependent antiprothrombin antibody on thrombin generation Arthritis Rheum 60 2457 2467 1:CAS:528:DC%2BD1MXhtV2hsLfO 10.1002/art.24708 19644870
63. C Bu L Gao W Xie, et al. 2009 Beta2-glycoprotein I is a cofactor for tissue plasminogen activator-mediated plasminogen activation Arthritis Rheum 60 559 568 1:CAS:528:DC%2BD1MXjt1Cnsrs%3D 10.1002/art.24262 19180513
64. MG Tektonidou K Laskari DB Panagiotakos HM Moutsopoulos 2009 Risk factors for thrombosis and primary thrombosis prevention in patients with systemic lupus erythematosus with or without antiphospholipid antibodies Arthritis Rheum 61 29 36 19116963
65. P Kahn M Ramanujam R Bethunaickan, et al. 2008 Prevention of murine antiphospholipid syndrome by BAFF blockade Arthritis Rheum 58 2824 2834 10.1002/art.23764 18759321
66. S Rahgozar B Giannakopoulos X Yan, et al. 2008 Beta2-glycoprotein I protects thrombin from inhibition by heparin cofactor II: potentiation of this effect in the presence of anti-beta2-glycoprotein I autoantibodies Arthritis Rheum 58 1146 1155 1:CAS:528:DC%2BD1cXltFGitrg%3D 10.1002/art.23387 18383370 (Pubitemid 351564018)