The effects of phosphatidylserine-dependent antiprothrombin antibody on thrombin generation

Arthritis and Rheumatism

Volumn 60, Issue 8, 2009, Pages 2457-2467

  Sakai, Yoshie ^a   Atsumi, Tatsuya ^a   Ieko, Masahiro ^b   Amengual, Olga ^a   Furukawa, Shin ^a   Furusaki, Akira ^a   Bohgaki, Miyuki ^a   Kataoka, Hiroshi ^a   Horita, Tetsuya ^a   Yasuda, Shinsuke ^a   Koike, Takao ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA2 GLYCOPROTEIN 1; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; CARDIOLIPIN ANTIBODY; CHROMOGENIC SUBSTRATE; D DIMER; FIBRIN; FIBRIN DEGRADATION PRODUCT; FIBRIN MONOMER; LUPUS ANTICOAGULANT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 231D; PHOSPHATIDYLSERINE; PROTHROMBIN; PROTHROMBIN ANTIBODY; THROMBIN; THROMBIN ANTITHROMBIN COMPLEX; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN BINDING; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; AUTOIMMUNITY; BINDING AFFINITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIBRINOLYSIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; THROMBIN TIME; THROMBOGENESIS;

ADOLESCENT; ADULT; AGED; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIPHOSPHOLIPID SYNDROME; AUTOANTIBODIES; BIOLOGICAL MARKERS; CELLS, CULTURED; FEMALE; FIBRIN; HUMANS; MALE; MICE; MICE, INBRED BALB C; MIDDLE AGED; PHOSPHATIDYLSERINES; PROTHROMBIN; THROMBIN; YOUNG ADULT;

EID: 68049110510     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24708     Document Type: Article

References (34)

1. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006;4:295-306.
2. Atsumi T, Matsuura E, Koike T. Immunology of antiphospholipid antibodies and cofactors. In: Lahita RG, editor. Systemic lupus erythematosus. 4th ed. San Diego: Academic Press; 2004. p. 1081-105.
3. Matsuura E, Igarashi Y, Fujimoto M, Ichikawa K, Koike T. Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease. Lancet 1990;336:177-8.
4. Galli M, Comfurius P, Maassen C, Hemker HC, de Baets MH, van Breda-Vriesman PJ, et al. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet 1990;335:952-3.
5. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA. Antiphospholipid antibodies are directed against a complex antigen that induces a lipid-binding inhibitor of coagulation: Beta2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci U S A 1990;87: 4120-4.
6. 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. J Exp Med 1994;179:457-62.
7. De Laat B, Derksen RH, Mackie IJ, Roest M, Schoormans S, Woodhams BJ, et al. Annexin A5 polymorphism (-1C→T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome. Ann Rheum Dis 2006;65:1468-72.
8. Loeliger A. Prothrombin as a cofactor of the circulating anticoagulant in systemic lupus erythematosus? Thromb Diath Haemorrh 1959;3:237-56.
9. Fleck RA, Rapaport SI, Rao LV. Anti-prothrombin antibodies and the lupus anticoagulant. Blood 1988;72:512-9.
10. Bevers EM, Galli M, Barbui T, Comfurius P, Zwaal RF. Lupus anticoagulant IgG's (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombin. Thromb Haemost 1991;66:629-32.
11. Oosting JD, Derksen RH, Bobbink IW, Hackeng TM, Bouma BN, de Groot PG. Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C, or protein S: an explanation for their pathogenic mechanism? Blood 1993;81:2618-25.
12. Arvieux J, Darnige L, Caron C, Reber G, Bensa JC, Colomb MG. Development of an ELISA for autoantibodies to prothrombin showing their prevalence in patients with lupus anticoagulant. Thromb Haemost 1995;74:1120-5.
13. Galli M. Should we include anti-prothrombin antibodies in the screening for the antiphospholipid syndrome? J Autoimmun 2000; 15:101-5.
14. Matsuda J, Saitoh N, Gotoh M, Kawasugi K, Gohchi K, Tsukamoto M. Phosphatidyl serine-dependent antiprothrombin antibody is exclusive to patients with lupus anticoagulant. Br J Rheumatol 1996;35:589-91.
15. Galli M, Beretta G, Daldossi M, Bevers EM, Barbui T. Different anticoagulant and immunological properties of anti-prothrombin antibodies in patients with antiphospholipid antibodies. Thromb Haemost 1997;77:486-91.
16. Atsumi T, Ieko M, Bertolaccini ML, Ichikawa K, Tsutsumi A, Matsuura E, et al. Association of autoantibodies against the phosphatidylserine-prothrombin complex with manifestations of the antiphospholipid syndrome and with the presence of lupus anticoagulant. Arthritis Rheum 2000;43:1982-93.
17. Harris EN, Gharavi AE, Patel BM, Hughes GR. Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1986. Clin Exp Immunol 1987;68:215-22.
18. Brandt JT, Triplett DA, Alving B, Scharrer I, on behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH. Criteria for the diagnosis of lupus anticoagulants: an update. Thromb Haemost 1995;74:1185-90.
19. Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975;256:495-7.
20. Bertolaccini ML, Atsumi T, Khamashta MA, Amengual O, Hughes GR. Autoantibodies to human prothrombin and clinical manifestations in 207 patients with systemic lupus erythematosus. J Rheumatol 1998;25:1104-8.
21. 2-glycoprotein I is necessary to inhibit protein C activity by monoclonal anticardiolipin antibodies. Arthritis Rheum 1999; 42:167-74.
22. Ames PR, Tommasino C, Iannaccone L, Brillante M, Cimino R, Brancaccio V. Coagulation activation and fibrinolytic imbalance in subjects with idiopathic antiphospholipid antibodies - a crucial role for acquired free protein S deficiency. Thromb Haemost 1996;76:190-4.
23. Atsumi T, Khamashta MA, Andujar C, Leandro MJ, Amengual O, Ames PR, et al. Elevated plasma lipoprotein(a) level and its association with impaired fibrinolysis in patients with antiphospholipid syndrome. J Rheumatol 1998;25:69-73.
24. 2-glycoprotein I-dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndrome. Blood 2004; 104:3598-602.
25. 2GPI and anti-prothrombin monoclonal antibodies. Thromb Haemost 2001;86:584-9.
26. Degen SJ, Davie EW. Nucleotide sequence of the gene for human prothrombin. Biochemistry 1987;26:6165-77.
27. Chow BK, Ting V, Tufaro F, MacGillivray RT. Characterization of a novel liver-specific enhancer in the human prothrombin gene. J Biol Chem 1991;266:18927-33.
28. Church WR, Ouellette LA, Messier TL. Modulation of human prothrombin activation on phospholipid vesicles and platelets using monoclonal antibodies to prothrombin fragment 2. J Biol Chem 1991;266:8384-91.
29. Zhao Y, Rumold R, Zhu M, Zhou D, Ahmed AE, Le DT, et al. An IgG antiprothrombin antibody enhances prothrombin binding to damaged endothelial cells and shortens plasma coagulation times. Arthritis Rheum 1999;42:2132-8.
30. 2-glycoprotein I antibodies. Int Immunol 2004;16:1633-41.
31. Vega-Ostertag M, Casper K, Swerlick R, Ferrara D, Harris EN, Pierangeli SS. Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies. Arthritis Rheum 2005;52:1545-54.
32. Lopez-Pedrera C, Buendia P, Cuadrado MJ, Siendones E, Aguirre MA, Barbarroja N, et al. Antiphospholipid antibodies from patients with the antiphospholipid syndrome induce monocyte tissue factor expression through the simultaneous activation of NF-κB/ Rel proteins via the p38 mitogen-activated protein kinase pathway, and of the MEK-1/ERK pathway. Arthritis Rheum 2006;54: 301-11.
33. 2-glycoprotein I on thrombin-mediated factor XIa generation. Arthritis Rheum 2007;56:605-13.
34. Koike T, Atsumi T. "Resurrection of thrombin" in the pathophysiology of the antiphospholipid syndrome [editorial]. Arthritis Rheum 2007;56:393-4.