Ultra scale-down stress analysis of the bioprocessing of whole human cells as a basis for cancer vaccines

Biotechnology and Bioengineering

Volumn 107, Issue 6, 2010, Pages 953-963

  Acosta Martinez, J P ^a   Papantoniou, I ^a   Lawrence, K ^a   Ward, S ^a   Hoare, M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Capillary; Human cells; Integrity; Stress; Surface markers; Ultra scale down

Indexed keywords

CAPILLARY; HUMAN CELLS; INTEGRITY; SURFACE MARKERS; ULTRA SCALE-DOWN;

CELL CULTURE; CELL MEMBRANES; COMPUTATIONAL FLUID DYNAMICS; DEBRIS; DESIGN OF EXPERIMENTS; FLUID DYNAMICS; HYDRODYNAMICS; SHEAR STRESS; STRENGTH OF MATERIALS; STRESS ANALYSIS; VACCINES;

BLOOD VESSELS;

CANCER VACCINE; CD147 ANTIGEN; CD59 ANTIGEN; CD81 ANTIGEN; CD9 ANTIGEN; HERMES ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TRYPAN BLUE;

ARTICLE; BIOPROCESS; CANCER CELL CULTURE; CAPILLARY; CAPILLARY FLOW; CELL LOSS; CELL MEMBRANE; CELL STRESS; CELL STRUCTURE; CELL SURFACE; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; FLOW RATE; GEOMETRY; HUMAN; HUMAN CELL; HYDRODYNAMICS; MALE; PROSTATE CANCER; SHEAR STRESS; WHOLE CELL;

BIOTECHNOLOGY; CANCER VACCINES; CELL CULTURE TECHNIQUES; CELL LINE; CELL MEMBRANE; HUMANS; HYDRODYNAMICS; MEMBRANE PROTEINS; STRESS, PHYSIOLOGICAL; TORSION, MECHANICAL;

EID: 78149459474     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22888     Document Type: Article

References (39)

1. Agashi K, Chau DYS, Shakesheff KM. 2009. The effect of delivery via narrow-bore needles on mesenchymal cells. Regen Med 4(1): 49-64.
2. Al-Rubeai M, Singh RP, Goldman MH, Emery AN. 1995. Death mechanisms of animal cells in conditions of intense agitation. Biotechnol Bioeng 45(6): 463-472.
3. Anderson R, Schneider J. 2007. Plasmid DNA and viral vector-based vaccines for the treatment of cancer. Vaccine 25S: B24-B34.
4. Berthon P, Cussenot HL, Le Duc A, Maitland N. 1995. Functional expression of SV40 in normal prostatic epithelial and fibroblastic cells: Differentiation pattern of non-tumourigenic cell lines. Int J Oncol 6: 333-343.
5. Born C, Zhang Z, Al-Rubeai M, Thomas CR. 1992. Estimation of disruption of animal cells by laminar shear stress. Biotechnol Bioeng 40(9): 1004-1010.
6. Brichard VG, Lejeune D. 2007. GSK's antigen-specific cancer immunotherapy programme: Pilot results leading to Phase III clinical development. Vaccine 25S: B61-B71.
7. Briske-Anderson MJ, Finley JW, Newman SM. 1997. The influence of culture time and passage number on the morphological and physiological development of Caco-2 cells. Proc Soc Exp Biol Med 214(3): 248-257.
8. Chisti Y. 2001. Hydrodynamic damage to animal cells. Crit Rev Biotech 21(2): 67-110.
9. Copier J, Ward S, Dalgleish A. 2007. Cell based cancer vaccines: Regulatory and commercial development. Vaccine 25S: B35-B46.
10. Croughan MS, Wang DIC. 1989. Growth and death in overagitated microcarrier cell cultures. Biotechnol Bioeng 33: 731-744.
11. Esquenet M, Swinnen JV, Heys W, Verhoeven G. 1997. LNCaP prostatic adenocarcinoma cells derived from low and high passage numbers display divergent responses not only to androgens but also to retinoids. J Steroid Biochem Mol Biol 62: 391-399.
12. European Medicines Agency. 2007. Committee for medicinal products for human use-guideline on potency testing of cell based immunotherapy medicinal products for the treatment of cancer. EMEA/CHMP/BWP/271475/2006.
13. Fernandes AM, Fernandes TG, Diogo MM, Lobato da Silva C, Henrique D, Cabral JMS. 2007. Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system. J Biotechnol 132: 227-236.
14. Garcia-Briones MA, Chalmers JJ. 1994. Flow parameters associated with hydrodynamic cell injury. Biotechnol Bioeng 44(9): 1089-1098.
15. Islam RS, Tisi D, Levy MS, Lye GJ. 2007. Framework for the rapid optimization of soluble protein expression in Escherichia coli combining microscale experiments and statistical experimental design. Biotechnol Prog 23: 785-793.
16. Kosaki K, Ando J, Korenaga R, Kurokawa T, Kamiya A. 1998. Fluid shear stress increases the production of granulocyte-macrophage colony-stimulating factor by endothelial cells via mRNA stabilization. Circ Res 82: 794-802.
17. Janmey PA, McCulloch CA. 2007. Cell mechanics: Integrating cell responses to mechanical stimuli. Annu Rev Biomed Eng 9: 1-34.
18. Labarthe MC, Halanek N, Birchall L, Russell N, Desel C, Todryk S, Peters MJ, Lucas A, Falkenberg FW, Dalgleish AG, Whelan M, Ward SJ. 2006. The biological effects of syngeneic and allogeneic cytokine-expressing prophylactic whole cell vaccines and the influence of irradiation in a murine melanoma model. Cancer Immunol Immunother 55: 277-288.
19. Lakhotia S, Bauer KD, Papoutsakis ET. 1992. Damaging agitation intensities increase DNA-synthesis rate and alter cell-cycle phase distributions of CHO cells. Biotechnol Bioeng 40(8): 978-990.
20. Lim M, Ye H, Panoskaltsis N, Drakakis EM, Yue X, Cass AEG, Radomska A, Mantalaris A. 2007. Intelligent bioprocessing for haemotopoietic cell cultures using monitoring and design of experiments. Biotechnol Adv 25: 353-368.
21. Ma N, Koelling KW, Chalmers JJ. 2002. Fabrication and use of a transient contractional flow device to quantify the sensitivity of mammalian and insect cells to hydrodynamic forces. Biotechnol Bioeng 80(4): 428-437.
22. Maitland NJ, Macintosh CA, Hall J, Sharrard M, Quinn G, Lang S. 2001. In vitro models to study cellular differentiation and function in human prostate cancers. Radiat Res 155(1): 133-142.
23. Mardikar SH, Niranjan K. 2000. Observations on the shear damage to different animal cells in a concentric cylinder viscometer. Biotechnol Bioeng 68(6): 697-704.
24. McCoy R, Ward S, Hoare M. 2009. Ultra scale-down studies of the effect of shear on cell quality; processing of a human cell line for vaccine cancer therapy. Biotechnol Prog 25(5): 1448-1458.
25. McCoy R, Ward S, Hoare M. 2010. Sub-population analysis of human cancer vaccine cells-Ultra scale-down characterization of response to shear. Biotechnol Bioeng 106(4): 584-597.
26. McDowell CL, Papoutsakis ET. 1998a. Increased agitation intensity increases CD13 receptor surface content and mRNA levels, and alters the metabolism of HL60 cells cultured in stirred tank bioreactors. Biotechnol Bioeng 60(2): 239-250.
27. McDowell CL, Papoutsakis ET. 1998b. Serum increases the CD13 receptor expression, reduces the transduction of fluid-mechanical forces, and alters the metabolism of HL60 cells cultured in agitated bioreactors. Biotechnol Bioeng 60(2): 259-268.
28. McQueen A, Meilhoc E, Bailey JE. 1987. Flow effects on the viability and lysis of suspended mammalian cells. Biotechnol Lett 9: 831-836.
29. Metallo CM, Vodyanik MA, Pablo JJ, Slukvin II, Palecek SP. 2008. The response of human embryonic stem cell-derived endothelial cells to shear stress. Biotechnol Bioeng 100(4): 830-836.
30. Michael A, Ball G, Quatan N, Wushishi F, Russell N, Whelan J, Chakraborty P, Leader D, Whelan M, Pandha H. 2005. Delayed disease progression after allogeneic cell vaccination in hormone-resistant prostate cancer and correlation with immunologic variables. Clin Cancer Res 11: 4469-4478.
31. Mollet M, Godoy-Silva R, Berdugo C, Chalmers JJ. 2007. Acute hydrodynamic forces and apoptosis: A complex question. Biotechnol Bioeng 98(4): 772-788.
32. Nicolette CA, Healey D, Tcherepanova I, Whelton P, Monesmith T, Coombs L, Finke LH, Whiteside T, Miesowicz F. 2007. Dendritic cells for active immunotherapy: Optimizing design and manufacture in order to develop commercially and clinically viable products. Vaccine 25S: B47-B60.
33. Sharp MK, Mohammad SF. 1998. Scaling of hemolysis in needles and catheters. Ann Biomed Eng 26: 788-797.
34. Terando A, Faries M, Morton D. 2007. Vaccine therapy for melanoma: Current status and future directions. Vaccine 25S: 14-16.
35. Tanzeglock T, Soos M, Stephanopoulos G, Morbidelli M. 2009. Induction of mammalian cell death by simple shear and extensional flows. Biotechnol Bioeng 104(2): 360-370.
36. Thomas RJ, Hourd PC, Williams DJ. 2008. Application of process quality engineering techniques to improve the understanding of the in vitro processing of stem cells for therapeutic use. J Biotechnol 136: 148-155.
37. Zhang Z, Al-Rubeai M, Thomas CR. 1993. Estimation of disruption of animal-cells by turbulent capillary-flow. Biotechnol Bioeng 42(8): 987-993.
38. Zhang Z, Chisti Y, Moo-Young M. 1995. Effects of the hydrodynamic environment and shear protectants on survival of erythrocytes in suspension. J Biotechnol 43: 33-40.
39. Zoro BJH, Owen S, Drake RAL, Hoare M. 2007. The impact of process stress on suspended anchorage-dependent mammalian cells as an indicator of likely challenges for regenerative medicines. Biotechnol Bioeng 99(2): 468-474.