Differential genetic regulation of canine hip dysplasia and osteoarthritis

PLoS ONE

Volumn 5, Issue 10, 2010, Pages

  Zhou, Zhengkui ^a,b,c   Sheng, Xihui ^b,c,d   Zhang, Zhiwu ^c   Zhao, Keyan ^c   Zhu, Lan ^e   Guo, Gang ^f   Friedenberg, Steve G ^c   Hunter, Linda S ^c   Vandenberg Foels, Wendy S ^c   Hornbuckle, William E ^c   Krotscheck, Ursula ^c   Corey, Elizabeth ^c   Moise, Nancy S ^c   Dykes, Nathan L ^c   Li, Junya ^b   Xu, Shangzhong ^b   Du, Lixin ^b   Wang, Yachun ^f   Sandler, Jody ^g   Acland, Gregory M ^c   Lust, George ^c   Todhunter, Rory J ^c   more..

^a NORTHWEST A F UNIVERSITY   (China)

^b INSTITUTE OF PLANT PROTECTION   (China)

^c Department of Obstetrics Gynecology   (United States)

^d BEIJING UNIVERSITY OF AGRICULTURE   (China)

^e OKLAHOMA STATE UNIVERSITY   (United States)

^f CHINA AGRICULTURAL UNIVERSITY   (China)

^g Guiding Eyes for the Blind   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 15; PROTEIN COL15A1; PROTEIN PARD3B; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE DELTA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DOG; GENE FUNCTION; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENETIC ASSOCIATION; GENETIC CODE; GENETIC IDENTIFICATION; GENETIC LINKAGE; GENETIC REGULATION; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENOTYPE; HIP DYSPLASIA; HIP OSTEOARTHRITIS; HUMAN VERSUS ANIMAL COMPARISON; NONHUMAN; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; ANIMAL DISEASE; BONE DYSPLASIA; CHROMOSOME MAP; DOG DISEASE; GENETICS; HIP; OSTEOARTHRITIS; PATHOLOGY;

CANIS FAMILIARIS;

ANIMALS; BONE DISEASES, DEVELOPMENTAL; CHROMOSOME MAPPING; DOG DISEASES; DOGS; GENETIC LINKAGE; HIP JOINT; OSTEOARTHRITIS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 78149427066     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013219     Document Type: Article

References (72)

1. Nakamura S, Ninomiya S, Nakamura T (1989) Primary osteoarthritis of the hip joint in Japan. Clin Orthop Relat Res. pp 190-196.
2. Yoshimura N, Campbell L, Hashimoto T, Kinoshita H, Okayasu T, et al. (1998) Acetabular dysplasia and hip osteoarthritis in Britain and Japan. Br J Rheumatol 37: 1193-1197.
3. Parentin F, Sangalli A, Mottes M, Perissutti P (2001) Stickler syndrome and vitreoretinal degeneration: correlation between locus mutation and vitreous phenotype. Apropos of a case. Graefes Arch Clin Exp Ophthalmol 239: 316-319.
4. Clements DN, Carter SD, Innes JF, Ollier WE (2006) Genetic basis of secondary osteoarthritis in dogs with joint dysplasia. Am J Vet Res 67: 909-918.
5. Smith GK, Mayhew PD, Kapatkin AS, McKelvie PJ, Shofer FS, et al. (2001) Evaluation of risk factors for degenerative joint disease associated with hip dysplasia in German Shepherd Dogs, Golden Retrievers, Labrador Retrievers, and Rottweilers. J Am Vet Med Assoc 219: 1719-1724.
6. Todhunter RJ, Grohn YT, Bliss SP, Wilfand A, Williams AJ, et al. (2003) Evaluation of multiple radiographic predictors of cartilage lesions in the hip joints of eight-month-old dogs. Am J Vet Res 64: 1472-1478.
7. Breur G, Lust G, Todhunter R (2001) Genetics of hip dysplasia and other orthopedic diseases. In: The genetics of the dog (eds A Ruvinsky and J Sampson). Wallingford, Oxon, UK: CAB International. pp 267-298.
8. Jacobsen S (2006) Adult hip dysplasia and osteoarthritis. Studies in radiology and clinical epidemiology. Acta Orthop Suppl 77: 1-37.
9. Weinstein SL (1987) Natural history of congenital hip dislocation (CDH) and hip dysplasia. Clin Orthop Relat Res. pp 62-76.
10. Jacobsen S, Sonne-Holm S (2005) Hip dysplasia: a significant risk factor for the development of hip osteoarthritis. A cross-sectional survey. Rheumatology (Oxford) 44: 211-218.
11. Cilliers HJ, Beighton P (1990) Beukes familial hip dysplasia: An autosomal dominant entity. American Journal of Medical Genetics 36: 386-390.
12. Stevenson DA, Mineau G, Kerber RA, Viskochil DH, Schaefer C, et al. (2009) Familial predisposition to developmental dysplasia of the hip. J Pediatr Orthop 29: 463-466.
13. Feldman G, Dalsey C, Fertala K, Azimi D, Fortina P, et al. (2009) The Otto Aufranc Award: Identification of a 4 Mb region on chromosome 17q21 linked to developmental dysplasia of the hip in one 18-member, multigeneration family. Clin Orthop Relat Res 468: 337-344.
14. Lark KG, Chase K, Sutter NB (2006) Genetic architecture of the dog: sexual size dimorphism and functional morphology. Trends in Genetics 22: 537-544.
15. Ostrander EA, Wayne RK (2005) The canine genome Genome Res 15: 1706-1716.
16. Mosher DS, Quignon P, Bustamante CD, Sutter NB, Mellersh CS, et al. (2007) A Mutation in the Myostatin Gene Increases Muscle Mass and Enhances Racing Performance in Heterozygote Dogs. PLoS Genet 3: e79.
17. Parker HG, Ostrander EA (2005) Canine Genomics and Genetics: Running with the Pack. PLoS Genet 1: e58.
18. Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, et al. (2005) Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature 438: 803-819.
19. Sutter NB, Bustamante CD, Chase K, Gray MM, Zhao K, et al. (2007) A Single IGF1 Allele Is a Major Determinant of Small Size in Dogs. Science 316: 112-115.
20. Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, et al. (2009) Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes. Science 326: 150-153.
21. Awano T, Johnson GS, Wade CM, Katz ML, Johnson GC, et al. (2009) Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 106: 2794-2799.
22. Parker HG, VonHoldt BM, Quignon P, Margulies EH, Shao S, et al. (2009) An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic Dogs. Science 325: 995-998.
23. Kerns JA, Cargill EJ, Clark LA, Candille SI, Berryere TG, et al. (2007) Linkage and segregation analysis of black and brindle coat color in domestic dogs. Genetics 176: 1679-1689.
24. Candille SI, Kaelin CB, Cattanach BM, Yu B, Thompson DA, et al. (2007) A -defensin mutation causes black coat color in domestic dogs. Science 318: 1418-1423.
25. Schmutz SM, Berryere TG, Goldfinch AD (2002) TYRP1 and MC1R genotypes and their effects on coat color in dogs. Mamm Genome 13: 380-387.
26. Rivadeneira F, Styrkarsdottir U, Estrada K, Halldorsson BV, Hsu YH, et al. (2009) Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet 41: 1199-1206.
27. Valdes AM, Loughlin J, Timms KM, van Meurs JJ, Southam L, et al. (2008) Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. Am J Hum Genet 82: 1231-1240.
28. Choi B, Suh Y, Kim WH, Christa L, Park J, et al. (2007) Downregulation of regenerating islet-derived 3 alpha (REG3A) in primary human gastric adenocarcinomas. Exp Mol Med 39: 796-804.
29. Marschall Y, Distl O (2007) Mapping quantitative trait loci for canine hip dysplasia in German Shepherd dogs. Mammalian Genome 18: 861-870.
30. Todhunter RJ, Mateescu R, Lust G, Burton-Wurster NI, Dykes NL, et al. (2005) Quantitative trait loci for hip dysplasia in a cross-breed canine pedigree. Mammalian Genome 16: 720-730.
31. Zhu L, Zhang Z, Feng F, Schweitzer P, Phavaphutanon J, et al. (2008) Single nucleotide polymorphisms refine QTL intervals for hip joint laxity in dogs. Anim Genet 39: 141-146.
32. Karlsson C, Dehne T, Lindahl A, Brittberg M, Pruss A, et al. (2010) Genomewide expression profiling reveals new candidate genes associated with osteoarthritis. Osteoarthritis Cartilage 18: 581-592.
33. Tompson SW, Ruiz-Perez VL, Blair HJ, Barton S, Navarro V, et al. (2007) Sequencing EVC and EVC2 identifies mutations in two-thirds of Ellis-van Creveld syndrome patients. Hum Genet 120: 663-670.
34. Schormair B, Kemlink D, Roeske D, Eckstein G, Xiong L, et al. (2008) PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. Nat Genet 40: 946-948.
35. Liu W, Faraco J, Qian C, Francke U (1997) The gene for microfibril-associated protein-1 (MFAP1) is located several megabases centromeric to FBN1 and is not mutated in Marfan syndrome. Hum Genet 99: 578-584.
36. Karlsson EK, Baranowska I, Wade CM, Salmon Hillbertz NH, Zody MC, et al. (2007) Efficient mapping of mendelian traits in dogs through genome-wide association. Nat Genet 39: 1321-1328.
37. Karlsson EK, Lindblad-Toh K (2008) Leader of the pack: gene mapping in dogs and other model organisms. Nat Rev Genet 9: 713-725.
38. Moonesinghe R, Khoury MJ, Janssens AC (2007) Most published research findings are false-but a little replication goes a long way. PLoS Med 4: e28.
39. Ioannidis JPA (2005) Why most published research findings are false. Plos Medicine 2: 696-701.
40. Lou XY, Todhunter RJ, Lin M, Lu Q, Liu T, et al. (2003) The extent and distribution of linkage disequilibrium in a multi-hierarchic outbred canine pedigree. Mamm Genome 14: 555-564.
41. Zhang Z, Ersoz E, Lai CQ, Todhunter RJ, Tiwari HK, et al. (2010) Mixed linear model approach adapted for genome-wide association studies. Nat Genet 42: 355-360.
42. Makarieva AM (2001) Variance of protein heterozygosity in different species of mammals with respect to the number of loci studied. Heredity 87: 41-51.
43. Higashino A, Osada N, Suto Y, Hirata M, Kameoka Y, et al. (2009) Development of an integrative database with 499 novel microsatellite markers for Macaca fascicularis. BMC Genet 10: 24.
44. Rogers J, Garcia R, Shelledy W, Kaplan J, Arya A, et al. (2006) An initial genetic linkage map of the rhesus macaque (Macaca mulatta) genome using human microsatellite loci. Genomics 87: 30-38.
45. Fuerst PA, Chakraborty R, Nei M (1977) Statistical studies on protein polymorphism in natural populations. I. Distribution of single locus heterozygosity. Genetics 86: 455-483.
46. Chase K, Lawler DF, Adler FR, Ostrander EA, Lark KG (2004) Bilaterally asymmetric effects of quantitative trait loci (QTLs): QTLs that affect laxity in the right versus left coxofemoral (hip) joints of the dog (Canis familiaris). Am J Med Genet A 124: 239-247.
47. Boyko AR, Quignon P, Li L, Schoenebeck JJ, Degenhardt JD, et al. A simple genetic architecture underlies morphological variation in dogs. PLoS Biol 8: e1000451.
48. Bliss S, Todhunter RJ, Quaas R, Casella G, Wu R, et al. (2002) Quantitative genetics of traits associated with hip dysplasia in a canine pedigree constructed by mating dysplastic Labrador Retrievers with unaffected Greyhounds. Am J Vet Res 63: 1029-1035.
49. Mateescu RG, Burton-Wurster NI, Tsai K, Phavaphutanon J, Zhang Z, et al. (2008) Identification of quantitative trait loci for osteoarthritis of hip joints in dogs. Am J Vet Res 69: 1294-1300.
50. Chase K, Lawler DF, Carrier DR, Lark KG (2005) Genetic regulation of osteoarthritis: A QTL regulating cranial and caudal acetabular osteophyte formation in the hip joint of the dog (Canis familiaris). Am J Med Genet A 135: 334-335.
51. Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, et al. (2010) Common SNPs explain a large proportion of the heritability for human height. Nat Genet 42: 565-569.
52. Lee JW, Waldron DF, Van Vleck LD (2000) Parameter estimates for greasy fleece weight of Rambouillet sheep at different ages. J Anim Sci 78: 2108-2112.
53. Mardis ER (2008) The impact of next-generation sequencing technology on genetics. Trends Genet 24: 133-141.
54. Uetani N, Chagnon MJ, Kennedy TE, Iwakura Y, Tremblay ML (2006) Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta. J Neurosci 26: 5872-5880.
55. Tsuritani K, Takeda J, Sakagami J, Ishii A, Eriksson T, et al. (2009) Cytokine receptor-like factor 1 is highly expressed in damaged human knee osteoarthritic cartilage and involved in osteoarthritis downstream of TGF-beta. Calcif Tissue Int 86: 47-57.
56. Kealy RD, Lawler DF, Ballam JM, Lust G, Biery DN, et al. (2000) Evaluation of the effect of limited food consumption on radiographic evidence of osteoarthritis in dogs. J Am Vet Med Assoc 217: 1678-1680.
57. Kealy RD, Lawler DF, Ballam JM, Lust G, Smith GK, et al. (1997) Five-year longitudinal study on limited food consumption and development of osteoarthritis in coxofemoral joints of dogs. J Am Vet Med Assoc 210: 222-225.
58. Kealy RD, Lawler DF, Monti KL, Biery D, Helms RW, et al. (1993) Effects of dietary electrolyte balance on subluxation of the femoral head in growing dogs. Am J Vet Res 54: 555-562.
59. Madsen JS, Svalastoga E (1994) Inclination and anteversion of collum femoris in hip dysplasia and coxarthritis. Acta Vet Scand 35: 115-119.
60. Todhunter RJ, Zachos TA, Gilbert RO, Erb HN, Williams AJ, et al. (1997) Onset of epiphyseal mineralization and growth plate closure in radiographically normal and dysplastic Labrador retrievers. J Am Vet Med Assoc 210: 1417-1418.
61. Yeh H, Chow M, Abrams WR, Fan J, Foster J, et al. (1994) Structure of the human gene encoding the associated microfibrillar protein (MFAP1) and localization to chromosome 15q15-q21. Genomics 23: 443-449.
62. Friedenberg SG, Zhu L, Zhang Z, van den Berg Foels W, Schweitzer PA, et al. (2010 (accepted)) A fibrillin 2 haplotype associated with canine hip dysplasia and incipient osteoarthritis. Am J Vet Res.
63. Ortiz EM, Dusetti NJ, Vasseur S, Malka D, Bodeker H, et al. (1998) The pancreatitis-associated protein is induced by free radicals in AR4-2J cells and confers cell resistance to apoptosis. Gastroenterology 114: 808-816.
64. Ikegawa S (2007) New gene associations in osteoarthritis: what do they provide, and where are we going? Curr Opin Rheumatol 19: 429-434.
65. Meulenbelt I, Min JL, van Duijn CM, Kloppenburg M, Breedveld FC, et al. (2006) Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes. Eur J Hum Genet 14: 1280-1287.
66. Zhang Z, Zhu L, Sandler J, Friedenberg SS, Egelhoff J, et al. (2009) Estimation of heritabilities, genetic correlations, and breeding values of four traits that collectively define hip dysplasia in dogs. American Journal of Veterinary Research 70: 483-492.
67. Lust G, Todhunter RJ, Erb HN, Dykes NL, Williams AJ, et al. (2001) Repeatability of dorsolateral subluxation scores in dogs and correlation with macroscopic appearance of hip osteoarthritis. American Journal of Veterinary Research 62: 1711-1715.
68. Lust G, Todhunter RJ, Erb HN, Dykes NL, Williams AJ, et al. (2001) Comparison of three radiographic methods for diagnosis of hip dysplasia in eight-month-old dogs. Journal of the American Veterinary Medical Association 219: 1242-1246.
69. Lust G (1997) An overview of the pathogenesis of canine hip dysplasia. J Am Vet Med Assoc 210: 1443-1445.
70. Phavaphutanon J, Mateescu RG, Tsai KL, Schweitzer PA, Corey EE, et al. (2009) Evaluation of quantitative trait loci for hip dysplasia in Labrador Retrievers. American Journal of Veterinary Research 70: 1094-1101.
71. Hardenbol P, Baner J, Jain M, Nilsson M, Namsaraev EA, et al. (2003) Multiplexed genotyping with sequence-tagged molecular inversion probes. Nat Biotechnol 21: 673-678.
72. Maffia M, Acierno R, Cillo E, Storelli C (1996) Na(+)-D-glucose cotransport by intestinal BBMVs of the Antarctic fish Trematomus bernacchii. Am J Physiol 271: R1576-1583.