Coat variation in the domestic dog is governed by variants in three genes

Science

Volumn 326, Issue 5949, 2009, Pages 150-153

  Cadieu, Edouard ^a   Neff, Mark W ^b   Quignon, Pascale ^a   Walsh, Kari ^b   Chase, Kevin ^c   Parker, Heidi G ^a   Vonholdt, Bridgett M ^d   Rhue, Alison ^b   Boyko, Adam B ^e   Byers, Alexandra ^a   Wong, Aaron ^b   Mosher, Dana S ^a   Elkahloun, Abdel G ^a   Spady, Tyrone C ^a   André, Catherine ^f   Lark, Gordon K ^c   Cargill, Michelle ^g,h   Bustamante, Carlos D ^e   Wayne, Robert K ^d   Ostrander, Elaine A ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Department of Obstetrics Gynecology   (United States)

^f CNRS   (France)

^g Affymetrix Corporation   (United States)

^h Genetics Navigenics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 5; GROWTH FACTOR; KERATIN; KERATIN 71; R SPONDIN 2; UNCLASSIFIED DRUG;

CANID; DOMESTIC SPECIES; GENE EXPRESSION; MORPHOLOGY; MUTATION; PHENOTYPE; PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BREEDING; CONTROLLED STUDY; DOG; DOMESTIC ANIMAL; GENE IDENTIFICATION; GENE MAPPING; GENE MUTATION; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC VARIABILITY; HAIR; HAIR COLOR; MICROARRAY ANALYSIS; NATURAL SELECTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED STATES;

3' UNTRANSLATED REGIONS; ANIMALS; DOGS; FIBROBLAST GROWTH FACTOR 5; GENOME-WIDE ASSOCIATION STUDY; HAIR; HAPLOTYPES; KERATINS, HAIR-SPECIFIC; LOD SCORE; MOLECULAR SEQUENCE DATA; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA; THROMBOSPONDINS; UNITED STATES;

CANIS FAMILIARIS;

EID: 70349675731     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1177808     Document Type: Article

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28. We gratefully acknowledge support from NSF grants 0733033 (R.K.W.) and 516310 (C.D.B.), NIH grants 1RO1GM83606 (C.D.B.) and GM063056 (K.G.L and K.C.), the Nestlé Purina company, the AKC Canine Health Foundation, the University of California-Davis Veterinary Genetics Laboratory, and the Intramural Program of the National Human Genome Research Institute. We thank L. Warren and S. Stafford for providing pictures. Finally, we thank the many dog owners who generously provided us with samples from their pets.