Tumor necrosis factor-α enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling

Stroke

Volumn 41, Issue 11, 2010, Pages 2618-2624

  Scherer, Elias Q ^a,c   Yang, Jingli ^h   Canis, Martin ^e   Reimann, Katrin ^f   Ivanov, Karolina ^a   Diehl, Christian D ^a   Backx, Peter H ^a,d   Wier, W Gil ^g   Strieth, Sebastian ^e   Wangemann, Philine ^f   Voigtlaender Bolz, Julia ^a   Lidington, Darcy ^a   Bolz, Steffen Sebastian ^a,b  

^a HEART AND STROKE FOUNDATION OF CANADA   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e UNIVERSITY OF MUNICH   (Germany)

^f KANSAS STATE UNIVERSITY   (United States)

^g UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^h NONE

Author keywords

cochlear microcirculation; etanercept; signal transduction; sphingosine kinase 1; transfection

Indexed keywords

4 (2,6 DICHLORO 4 PYRIDINYL) 1 (1,3 DIMETHYL 4 ISOPROPYL 1H PYRAZOLO[3,4 B]PYRIDIN 6 YL)SEMICARBAZIDE; CALCIUM; ETANERCEPT; PREDNISOLONE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; SPHINGOSINE KINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUDITORY THRESHOLD; BLOOD VESSEL TONE; CAPILLARY FLOW; CLINICAL ARTICLE; COCHLEA BLOOD FLOW; CONTROLLED STUDY; DRUG HALF LIFE; DRUG INHIBITION; ENZYME ACTIVATION; EX VIVO STUDY; FLUORESCENCE MICROSCOPY; GERBIL; GUINEA PIG; HUMAN; IN VIVO STUDY; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER MEMBRANE; SPIRAL LIGAMENT; SUDDEN DEAFNESS; TREATMENT DURATION;

ADULT; ANIMALS; CALCIUM; COCHLEA; GERBILLINAE; GUINEA PIGS; HEARING LOSS; HUMANS; IMMUNOGLOBULIN G; LYSOPHOSPHOLIPIDS; MICROVESSELS; MODELS, ANIMAL; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTORS, TUMOR NECROSIS FACTOR; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION; SPHINGOSINE; SPIRAL LIGAMENT OF COCHLEA; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA; VASOCONSTRICTION;

EID: 78149361078     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.110.593327     Document Type: Article

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