Repeated ethanol exposure during late gestation decreases nephron endowment in fetal sheep

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 295, Issue 2, 2008, Pages

  Gray, Stephen P ^a   Kenna, Kelly ^a   Bertram, John F ^a   Hoy, Wendy E ^b   Yan, Edwin B ^a   Bocking, Alan D ^c   Brien, James F ^d   Walker, David W ^a   Harding, Richard ^a   Moritz, Karen M ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF TORONTO   (Canada)

^d QUEEN S UNIVERSITY   (Canada)

Author keywords

Ethanol exposure; Fetus; Kidney; Nephron number; Sheep

Indexed keywords

ALCOHOL; MESSENGER RNA;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FETUS; FETUS DEVELOPMENT; GESTATIONAL AGE; KIDNEY DEVELOPMENT; KIDNEY FUNCTION; KIDNEY SIZE; NEPHRON; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SHEEP; AMNION FLUID; ANIMAL; BLOOD; BODY WEIGHT; DRUG EFFECT; FETUS BLOOD; FETUS WEIGHT; GENE EXPRESSION REGULATION; GENETICS; GLOMERULUS; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; ORGANOGENESIS; PRENATAL DEVELOPMENT; PRENATAL EXPOSURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMNIOTIC FLUID; ANIMALS; BODY WEIGHT; ETHANOL; FEMALE; FETAL BLOOD; FETAL WEIGHT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GESTATIONAL AGE; INFUSIONS, INTRAVENOUS; KIDNEY GLOMERULUS; NEPHRONS; ORGANOGENESIS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SHEEP;

EID: 51149107617     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90316.2008     Document Type: Article

References (50)

1. Abel EL. Consumption of alcohol during pregnancy: a review of effects on growth and development of offspring. Hum Biol 54: 421-453, 1982.
2. Assadi F, Manaligod JR, Fleischmann LE, Zajac CS. Effects of prenatal ethanol exposure on postnatal renal function and structure in the rat. Alcohol 8: 259-263, 1991.
3. Bertram JF. Analyzing renal glomeruli with the new stereology. Int Rev Cell Mol Biol 161: 111-170, 1995.
4. Bertram JF. Counting in the kidney. Kidney Int 59: 792-796, 2001.
5. Bertram C, Trowern AR, Copin N, Jackson AA, Whorwood CB. The maternal diet during pregnancy programs altered expression of the glucocorticoid receptors and type 2 11β-hydroxysteroid dehydrogenase: Potential molecular mechanisms underlying the programming of hypertension in utero. Endocrinology 142: 2841-2853, 2001.
6. Bonnichsen R, Lundgren G. Comparison of the ADH and the Widmark procedures in forensic chemistry for determining alcohol. Acta Pharmacol Toxicol (Copenh) 13: 256-266, 1957.
7. Brenner B, Garcia DL, Anderson S. Glomeruli and blood pressure. Am J Hypertens 1: 335-347, 1988.
8. Caetano R, Ramisetty-Mikler S, Floyd LR, McGrath C. The epidemiology of drinking among women of child-bearing age. Alcohol Clin Exp Res 30: 1023-1030, 2006.
9. Chang G, McNamara TK, Orav EJ, Wilkins-Haug L. Alcohol use by pregnant women: partners, knowledge, and other predictors. J Stud Alcohol 67: 245-251, 2006.
10. Clarke D, Wlodek ME, Patrick J, Richardson B, Brien JF. Decreased urine production in the near-term fetal lamb after maternal ethanol infusion. Am J Obstet Gynecol 156: 1273-1274, 1987.
11. Cock ML, Harding R. Renal and amniotic fluid responses to umbilico-placental embolization for 20 days in fetal sheep. Am J Physiol Regul Integr Comp Physiol 273: R1094-R1102, 1997.
12. Colvin L, Payne J, Parsons D, Kurinczuk JJ, Bower C. Alcohol consumption during pregnancy in nonindigenous West Australian women. Alcohol Clin Exp Res 31: 276-284, 2007.
13. Day NL, Richardson GA. Prenatal alcohol exposure: A continuum of effects. Semin Perinatol 15: 271-279, 1991.
14. Dickinson H, Walker DW, Wintour EM, Moritz KM. Maternal dexamethasone treatment at midgestation reduces nephron number and alters renal gene expression in the fetal spiny mouse. Am J Physiol Regul Integr Comp Physiol 292: R453-R461, 2007.
15. Dobson A, Sellers AF, Gatewood VH. Absorption and exchange of water across rumen epithelium. Am J Physiol 231: 1588-1594, 1976.
16. Dodic M, Abouatoun T, O'Connor A, Wintour EM, Moritz KM. Programming effects of short prenatal exposure to dexamethasone in sheep. Hypertension 40: 729-734, 2002.
17. Friberg P, Sundelin B, Bohman SO, Bobik A, Nilsson H, Wickman A, Gustafsson H, Petersen J, Adams MA. Renin-angiotensin system in neonatal rats: induction of a renal abnormality in response to ACE inhibition or angiotensin II antagonism. Kidney Int 45: 485-492, 1994.
18. Gallo P, Weinberg J. Organ growth and cellular development in ethanol-exposed rats. Alcohol 3: 261-267, 1986.
19. Gatford KL, Dalitz PA, Cock ML, Harding R, Owens JA. Acute ethanol exposure in pregnancy alters the insulin-like growth factor axis of fetal and maternal sheep. Am J Physiol Endocrinol Metab 292: E494-E500, 2007.
20. Gray SP, Courtney-Jones K, Bartal D, Cullen-McEwen LA, Moritz KM, Brien JF. Prenatal alcohol exposure in the rat alters kidney development and elevates systolic blood pressure (Abstract). Alcohol Clin Exp Res 30, Supp 1: 174A, 2006.
21. Hantzis V, Albiston A, Matsacos D, Wintour EM, Peers A, Koukoulas I, Mylers K, Moritz KM, Dodic M. Effect of early glucocoticoid treatment on MR and GR in late gestation ovine kidney. Kidney Int 61: 405-413, 2002.
22. Havers W, Majewski F, Olbing H, Eickenberg HU. Anomalies of the kidneys and genitourinary tract in alcoholic embryopathy. J Urol 124: 108-110, 1980.
23. Hoy W, Hughson MD, Singh GR, Douglas-Denton R, Bertram JF. Reduced nephron number and glomerulomegaly in Australian Aborigines: A group at high risk for renal disease and hypertension. Kidney Int 70: 104-110, 2006.
24. Kasking P, Shortell C, Machalek M. University students' knowledge of alcoholic drinks and their perception of alcohol-related harm. J Drug Educ 35: 95-109, 2005.
25. Langley-Evans S, Welham SJM, Jackson AA. Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat. Life Sci 64: 965-974, 1999.
26. Lelong N, Kaminski M, Chwalon J, Bean K, Subtil D. Attitudes and behavior of pregnant women and health professionals towards alcohol and tobacco consumption. Patient Educ Couns 25: 39-49, 1995.
27. Malet L, de Chazeron I, Llorca PM, Lemery D. Alcohol consumption during pregnancy: a urge to increase prevention and screening. Eur J Epidemiol 21: 787-788, 2006.
28. McMullen S, Gardner DS, Langley-Evans SC. Prenatal programming of angiotensin II type 2 receptor expression in the rat. Br J Nutr 91: 133-140, 2004.
29. Moritz KM, Johnson K, Douglas-Denton R, Wintour EM, Dodic M. Maternal glucocorticoid treatment programs alterations in the renin-angiotensin system of the ovine fetal kidney. Endocrinology 143: 4455-4463, 2002.
30. Moushmoush B, Abi-Mansour P. Alcohol and the heart. The long-term effects of alcohol on the cardiovascular system. Arch Intern Med 151: 36-42, 1991.
31. Nyengaard JR. Stereologic methods and their application in kidney research. J Am Soc Nephrol 10: 1100-1123, 1999.
32. Qazi Q, Masakawa A, Milman D, McGann B, Chua A, Haller J. Renal anomalies in fetal alcohol syndrome. Pediatrics 63: 886-889, 1979.
33. Sahajpal V, Ashton N. Renal function and angiotensin AT1 receptor expression in young rats following intrauterine exposure to a maternal low-protein diet. Clin Sci (Lond) 104: 607-614, 2003.
34. Sanr'Anna L, Tosello D. Fetal alcohol syndrome and developing craniofacial and dental structures-a review. Orthod Craniofac Res 9: 172-185, 2006.
35. Singh R, Cullen-McEwen LA, Kett MM, Boom WM, Dowling J, Bertram JF, Moritz KM. Prenatal corticosterone exposure results in altered AT1/AT2, nephron deficit and hypertension in the rat offspring. J Physiol 579: 503-513, 2007.
36. Strandberg-Larsen K, Anderson AM, Olsen J, Nielsen NR, Gronbaek M. Do women give the same information on binge drinking during pregnancy when asked repeatedly? Eur J Clin Nutr 60: 1294-1298, 2006.
37. Taylor C, Jones KL, Jones MC, Kaplan GW. Incidence of renal anomalies in children prenatally exposed to ethanol. Pediatrics 94: 209-212, 1994.
38. Tsai J, Floyd RL, Green PP, Boyle CA. Patterns and average volume of alcohol use among women of childbearing age. Matern Child Health J 11: 437-445, 2007.
39. Vehaskari VM, Stewart T, Lafont D, Soyez C, Seth D, Manning J. Kidney angiotensin and angiotensin receptor expression in prenatally programmed hypertension. Am J Physiol Renal Physiol 287: F262-F267, 2004.
40. Warner AC, Stacy BD. Water, sodium and potassium movements across the rumen wall of sheep. Q J Exp Physiol Cogn Med Sci 57: 103-119, 1972.
41. White AM, Kraus CL, Flom JD, Kestenbaum LA, Mitchell JR, Shah K, Swartzwlder HS. College students lack knowledge of standard drink volumes: Implications for definitions of risky drinking based on survey data. Alcohol Clin Exp Res 29: 631-638, 2005.
42. WHO. Global Status Report on Alcohol Policy. Department of Mental Health, and Substance Abuse: Geneva, Switzerland, 2004.
43. Whorwood CB, Firth KM, Budge H, Symonds ME. Maternal undernutrition during early to midgestation programs tissue-specific alterations in the expression of the glucocoticoid receptor, 11β-hydroxysteroid dehydrogenase isoforms, and type 1 angiotensin II receptor in neonatal sheep. Endocrinology 142: 2854-2864, 2001.
44. Wintour EM, Moritz KM, Johnson K, Ricardo S, Samuel CS, Dodic M. Reduced nephron number in adult sheep hypertensive as a result of prenatal glucocoticoid treatment. J Physiol 549: 929-935, 2003.
45. Wlodek ME, Mibus A, Tan A, Siebel AL, Owens JA, Moritz KM. Normal lactational environment restores nephron endowment and prevents hypertension after placental restriction in the rat. J Am Soc Nephrol 18: 1688-1696, 2007.
46. Woods LL, Ingelfinger JR, Nyengaard JR, Rasch R. Maternal protein restriction suppresses the newborn renin-angiotensin system and programs adult hypertension in rats. Pediatr Res 49: 460-467, 2001.
47. Woods L, Weeks DA, Rasch A. Programming of adult blood pressure by maternal protein restriction: role of nephrogenesis. Kidney Int 65: 1339-1348, 2004.
48. Zang X, Silwowska JH, Weinberg J. Prenatal alcohol exposure and fetal programming: effects on neuroendocrine and immune Function. Exp Biol Med 230: 376-388, 2005.
49. Zoetis T, Hurtt ME. Species comparison of anatomical and functional renal development. Birth Defects Res B Dev Reprod Toxicol 68: 111-120, 2003.
50. Zohdi V, Moritz KM, Bubb KJ, Cock ML, Wreford N, Harding R, Black MJ. Nephrogenesis and the renal renin-angiotensin system in fetal sheep: effects of intrauterine growth restriction during late gestation. Am J Physiol Regul Integr Comp Physiol 293: R1267-R1273, 2007.